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J Biol Chem, Vol. 273, Issue 13, 7691-7697, March 27, 1998
From the To define genes associated with or responsible
for the neurodegenerative changes observed in transmissible spongiform
encephalopathies, we analyzed gene expression in scrapie-infected mouse
brain using "mRNA differential display." The RNA transcripts of
eight genes were increased 3-8-fold in the brains of scrapie-infected
animals. Five of these genes have not previously been reported to
exhibit increased expression in this disease: cathepsin S, the
C1q B-chain of complement, apolipoprotein D, and two
previously unidentified genes denominated scrapie-responsive gene
(ScRG)-1 and ScRG-2, which are
preferentially expressed in brain tissue. Increased expression of the
three remaining genes,
Gene Expression in Scrapie
CLONING OF A NEW SCRAPIE-RESPONSIVE GENE AND THE IDENTIFICATION
OF INCREASED LEVELS OF SEVEN OTHER mRNA TRANSCRIPTS
,,,
,,,, and
Laboratoire d'Oncologie Virale CNRS UPR
9045, IFC1, 94801 Villejuif cedex France and the Laboratoire de
Neurovirologie CEA, 92265 Fontenay aux Roses cedex, France
2 microglobulin, F4/80, and
metallothionein II, has previously been reported to occur in
experimental scrapie. Kinetic analysis revealed a concomitant increase
in the levels of ScRG-1, cathepsin S, the C1q
B-chain of complement, and 2 microglobulin mRNA as well as
glial fibrillary acidic protein and F4/80 transcripts,
markers of astrocytosis and microglial activation, respectively. In
contrast, the level of ScRG-2, apolipoprotein D, and
metallothionein II mRNA was only increased at the terminal stage of
the disease. ScRG-1 mRNA was found to be preferentially
expressed in glial cells and to code for a short protein of 47 amino
acids with a strong hydrophobic N-terminal region.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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