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J Biol Chem, Vol. 273, Issue 14, 7783-7786, April 3, 1998
From the Center for Apoptosis Research and the Department of
Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson
University, Philadelphia, Pennsylvania 19107
We identified and cloned a novel murine member of
the pro-apoptotic Bcl-2 family. This protein, designated Blk, is
structurally and functionally related to human Bik and localized to the
mitochondrial membrane. Blk contains a conserved BH3 domain and can
interact with the anti-apoptotic proteins Bcl-2 and Bcl-xL. Ectopic
expression of Blk in mammalian cells induces apoptosis, which can be
inhibited by mutations in the BH3 domain and by overexpression of Bcl-2 or Bcl-xL but not by CrmA. The apoptotic activity of Blk is also inhibited by a dominant negative caspase-9, suggesting that Blk induces
apoptosis through activation of the cytochrome
c-Apaf-1-caspase-9 pathway.
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