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J Biol Chem, Vol. 273, Issue 15, 8556-8559, April 10, 1998
From the Rockefeller University, New York, New York 10021
The small G-protein Cdc42 functions in many
eukaryotic signal transduction pathways. In the budding yeast
Saccharomyces cerevisiae, cells with defective Cdc42 fail
to induce mating-specific genes in response to mating factor and to
adopt the proper morphology for conjugation. Here we show that the
failure of mating factor-induced transcription is largely the indirect
result of arrest at a specific cell cycle position and/or the
accumulation of high levels of the Cln1/2-Cdc28 kinase, a known
repressor of mating factor signal transduction. Cdc42-defective
cells with restored transcriptional induction have a
partially restored mating ability but are still defective in the
morphological response to mating factor. These results show that Cdc42
is not required for transduction of the mating factor signal per
se but that it is essential for proper mating factor-induced
morphogenesis.
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