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J Biol Chem, Vol. 273, Issue 15, 8922-8931, April 10, 1998

Mechanism of Sodium Arsenite-mediated Induction of Heme Oxygenase-1 in Hepatoma Cells
ROLE OF MITOGEN-ACTIVATED PROTEIN KINASES

Kimberly K. Elbirt, Alan J. Whitmarsh^¶, Roger J. Davis^¶, and Herbert L. Bonkovsky

From the Departments of  Medicine and  Biochemistry and Molecular Biology, Howard Hughes Medical Institute and ^¶ Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655

Heme oxygenase-1 is an inducible enzyme that catalyzes heme degradation and has been proposed to play a role in protecting cells against oxidative stress-related injury. We investigated the induction of heme oxygenase-1 by the tumor promoter arsenite in a chicken hepatoma cell line, LMH. We identified a heme oxygenase-1 promoter-driven luciferase reporter construct that was highly and reproducibly expressed in response to sodium arsenite treatment. This construct was used to investigate the role of mitogen-activated protein (MAP) kinases in arsenite-mediated heme oxygenase-1 gene expression. In LMH cells, sodium arsenite, cadmium, and heat shock, but not heme, induced activity of the MAP kinases extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. To examine whether these MAP kinases were involved in mediating heme oxygenase-1 gene expression, we utilized constitutively activated and dominant negative components of the ERK, JNK, and p38 MAP kinase signaling pathways. Involvement of an AP-1 site in arsenite induction of heme oxygenase-1 gene expression was studied. We conclude that the MAP kinases ERK and p38 are involved in the induction of heme oxygenase-1, and that at least one AP-1 element (located 1576 base pairs upstream of the transcription start site) is involved in this response.

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