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J Biol Chem, Vol. 273, Issue 15, 9099-9109, April 10, 1998
From the Murine ZFP-37 is a member of the large family of
C2H2 type zinc finger proteins. It is
characterized by a truncated NH2-terminal Krüppel-associated box and is thought to play a role in
transcriptional regulation. During development Zfp-37
mRNA is most abundant in the developing central nervous system, and
in the adult mouse expression is restricted largely to testis and
brain. Here we show that at the protein level ZFP-37 is detected
readily in neurons of the adult central nervous system but hardly in
testis. In brain ZFP-37 is associated with nucleoli and appears to
contact heterochromatin. Mouse and human ZFP-37 have a basic histone
H1-like linker domain, located between KRAB and zinc finger regions,
which binds double-stranded DNA. Thus we suggest that ZFP-37 is a
structural protein of the neuronal nucleus which plays a role in the
maintenance of specialized chromatin domains.
The Centromeric/Nucleolar Chromatin Protein ZFP-37 May Function
to Specify Neuronal Nuclear Domains
,,,
,,,, and
Department of Cell Biology and Genetics and
the Department of Anatomy, Erasmus
University, P. O. Box 1738, 3000 DR Rotterdam, The Netherlands,
the ** Department of Molecular and Human Genetics, Baylor College of
Medicine, Houston, Texas 77030, and Children's Hospital,
University of Mainz, D-55101 Mainz, Germany
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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