| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 15, 9297-9305, April 10, 1998
From the Department of Pharmacology and Neuroscience Program,
University of Colorado Health Sciences Center, Denver, Colorado 80262 and The ability of adenylyl cyclases to be regulated
by physiological transitions in Ca2+ provides a key
point for integration of cytosolic Ca2+ concentration
([Ca2+]i) and cAMP signaling.
Ca2+-sensitive adenylyl cyclases, whether endogenously or
heterologously expressed, require Ca2+ entry for their
regulation, rather than Ca2+ release from intracellular
stores (Chiono, M., Mahey, R., Tate, G., and Cooper, D. M. F. (1995) J. Biol. Chem. 270, 1149-1155; Fagan, K.,
Mahey, R., and Cooper, D. M. F. (1996) J. Biol.
Chem. 271, 12438-12444). The present study compared the
regulation by capacitative Ca2+ entry versus
ionophore-mediated Ca2+ entry of an endogenously expressed
Ca2+-inhibitable adenylyl cyclase in C6-2B cells. Even in
the face of a dramatic [Ca2+]i rise generated
by ionophore, Ca2+ entry via capacitative Ca2+
entry channels was solely responsible for the regulation of the adenylyl cyclase. Selective efficacy of BAPTA over equal concentrations of EGTA in blunting the regulation of the cyclase by capacitative Ca2+ entry defined the intimacy between the adenylyl
cyclase and the capacitative Ca2+ entry sites. This
association could not be impaired by disruption of the cytoskeleton by
a variety of strategies. These results not only establish an intimate
spatial relationship between an endogenously expressed
Ca2+-inhibitable adenylyl cyclase with capacitative
Ca2+ entry sites but also provide a physiological role for
capacitative Ca2+ entry other than store refilling.
Dependence of the Ca2+-inhibitable Adenylyl Cyclase
of C6-2B Glioma Cells on Capacitative Ca2+ Entry
, and URA-CNRS 339, University of Bordeaux I, Talence
F-33405, France
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. B. Parekh Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function J. Physiol., July 1, 2008; 586(13): 3043 - 3054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-C. Chang, J. Di Capite, K. Singaravelu, C. Nelson, V. Halse, and A. B. Parekh Local Ca2+ Influx through Ca2+ Release-activated Ca2+ (CRAC) Channels Stimulates Production of an Intracellular Messenger and an Intercellular Pro-inflammatory Signal J. Biol. Chem., February 22, 2008; 283(8): 4622 - 4631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Willoughby and D. M. F. Cooper Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains Physiol Rev, July 1, 2007; 87(3): 965 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. L. Martin and D. M. F. Cooper Capacitative and 1-Oleyl-2-acetyl-sn-glycerol-Activated Ca2+ Entry Distinguished Using Adenylyl Cyclase Type 8 Mol. Pharmacol., August 1, 2006; 70(2): 769 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Willoughby and D. M. F. Cooper Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP J. Cell Sci., March 1, 2006; 119(5): 828 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Crossthwaite, A. Ciruela, T. F. Rayner, and D. M. F. Cooper A Direct Interaction between the N Terminus of Adenylyl Cyclase AC8 and the Catalytic Subunit of Protein Phosphatase 2A Mol. Pharmacol., February 1, 2006; 69(2): 608 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Rizzuto and T. Pozzan Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences Physiol Rev, January 1, 2006; 86(1): 369 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Willoughby, N. Masada, A. J. Crossthwaite, A. Ciruela, and D. M. F. Cooper Localized Na+/H+ Exchanger 1 Expression Protects Ca2+-regulated Adenylyl Cyclases from Changes in Intracellular pH J. Biol. Chem., September 2, 2005; 280(35): 30864 - 30872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Dyer, Y. Liu, I. P. de la Huerga, and C. W. Taylor Long Lasting Inhibition of Adenylyl Cyclase Selectively Mediated by Inositol 1,4,5-Trisphosphate-evoked Calcium Release J. Biol. Chem., March 11, 2005; 280(10): 8936 - 8944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Crossthwaite, T. Seebacher, N. Masada, A. Ciruela, K. Dufraux, J. E. Schultz, and D. M. F. Cooper The Cytosolic Domains of Ca2+-sensitive Adenylyl Cyclases Dictate Their Targeting to Plasma Membrane Lipid Rafts J. Biol. Chem., February 25, 2005; 280(8): 6380 - 6391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Goraya, N. Masada, A. Ciruela, and D. M. F. Cooper Sustained Entry of Ca2+ Is Required to Activate Ca2+-Calmodulin-dependent Phosphodiesterase 1A J. Biol. Chem., September 24, 2004; 279(39): 40494 - 40504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Bautista and R. S. Lewis Modulation of plasma membrane calcium-ATPase activity by local calcium microdomains near CRAC channels in human T cells J. Physiol., May 1, 2004; 556(3): 805 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. Antoni, A. A. Sosunov, A. Haunso, J. M. Paterson, and J. Simpson Short-Term Plasticity of Cyclic Adenosine 3',5'-Monophosphate Signaling in Anterior Pituitary Corticotrope Cells: The Role of Adenylyl Cyclase Isotypes Mol. Endocrinol., April 1, 2003; 17(4): 692 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Creighton, N. Masada, D. M. F. Cooper, and T. Stevens Coordinate regulation of membrane cAMP by Ca2+-inhibited adenylyl cyclase and phosphodiesterase activities Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L100 - L107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hu, H. Nakata, C. Gu, T. de Beer, and D. M. F. Cooper A Critical Interplay between Ca2+ Inhibition and Activation by Mg2+ of AC5 Revealed by Mutants and Chimeric Constructs J. Biol. Chem., August 30, 2002; 277(36): 33139 - 33147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Cioffi, T. M. Moore, J. Schaack, J. R. Creighton, D. M.F. Cooper, and T. Stevens Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase J. Cell Biol., June 24, 2002; 157(7): 1267 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Sunahara and R. Taussig Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling Mol. Interv., June 1, 2002; 2(3): 168 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Smith, C. Gu, K. A. Fagan, B. Hu, and D. M. F. Cooper Residence of Adenylyl Cyclase Type 8 in Caveolae Is Necessary but Not Sufficient for Regulation by Capacitative Ca2+ Entry J. Biol. Chem., February 15, 2002; 277(8): 6025 - 6031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tian and S. G. Laychock Protein Kinase C and Calcium Regulation of Adenylyl Cyclase in Isolated Rat Pancreatic Islets Diabetes, November 1, 2001; 50(11): 2505 - 2513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Stevens Is there a role for store-operated calcium entry in vasoconstriction? Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L866 - L869. [Full Text] [PDF]
|
|
|
|
|
|
S. F. Mahmoud and C. Fewtrell Microdomains of High Calcium Are Not Required for Exocytosis in RBL-2H3 Mucosal Mast Cells J. Cell Biol., April 16, 2001; 153(2): 339 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Z. Krsmanovic, N. Mores, C. E. Navarro, M. Tomic, and K. J. Catt Regulation of Ca2+-Sensitive Adenylyl Cyclase in Gonadotropin-Releasing Hormone Neurons Mol. Endocrinol., March 1, 2001; 15(3): 429 - 440. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. Sampaio-Maia, M. P. Serrao, and P. Soares-da-Silva Regulatory pathways and uptake of L-DOPA by capillary cerebral endothelial cells, astrocytes, and neuronal cells Am J Physiol Cell Physiol, February 1, 2001; 280(2): C333 - C342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Norwood, T. M. Moore, D. A. Dean, R. Bhattacharjee, M. Li, and T. Stevens Store-operated calcium entry and increased endothelial cell permeability Am J Physiol Lung Cell Mol Physiol, November 1, 2000; 279(5): L815 - L824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-L. Cui, W.-W. Jin, Y.-X. Ding, L. D. Alexander, U. Hopfer, and J. G. Douglas Ca2+-dependent activation of c-jun NH2-terminal kinase in primary rabbit proximal tubule epithelial cells Am J Physiol Cell Physiol, August 1, 2000; 279(2): C403 - C409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lin, K. A. Fagan, K.-X. Li, P. W. Shaul, D. M. F. Cooper, and D. M. Rodman Sustained Endothelial Nitric-oxide Synthase Activation Requires Capacitative Ca2+ Entry J. Biol. Chem., June 9, 2000; 275(24): 17979 - 17985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M.B. O'Toole, C. Arnoult, A. Darszon, R. A. Steinhardt, and H. M. Florman Ca2+ Entry through Store-operated Channels in Mouse Sperm Is Initiated by Egg ZP3 and Drives the Acrosome Reaction Mol. Biol. Cell, May 1, 2000; 11(5): 1571 - 1584. [Abstract] [Full Text]
|
|
|
|
|
|
C. Gu and D. M. F. Cooper Ca2+, Sr2+, and Ba2+ Identify Distinct Regulatory Sites on Adenylyl Cyclase (AC) Types VI and VIII and Consolidate the Apposition of Capacitative Cation Entry Channels and Ca2+-sensitive ACs J. Biol. Chem., March 15, 2000; 275(10): 6980 - 6986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Guillou, H. Nakata, and D. M. F. Cooper Inhibition by Calcium of Mammalian Adenylyl Cyclases J. Biol. Chem., December 10, 1999; 274(50): 35539 - 35545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Shuttleworth and J. L. Thompson Discriminating between Capacitative and Arachidonate-activated Ca2+ Entry Pathways in HEK293 Cells J. Biol. Chem., October 29, 1999; 274(44): 31174 - 31178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Muth, H. Yamaguchi, G. Mikala, I. L. Grupp, W. Lewis, H. Cheng, L.-S. Song, E. G. Lakatta, G. Varadi, and A. Schwartz Cardiac-specific Overexpression of the alpha 1 Subunit of the L-type Voltage-dependent Ca2+ Channel in Transgenic Mice. LOSS OF ISOPROTERENOL-INDUCED CONTRACTION J. Biol. Chem., July 30, 1999; 274(31): 21503 - 21506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Fagan, T. C. Rich, S. Tolman, J. Schaack, J. W. Karpen, and D. M. F. Cooper Adenovirus-mediated Expression of an Olfactory Cyclic Nucleotide-gated Channel Regulates the Endogenous Ca2+-inhibitable Adenylyl Cyclase in C6-2B Glioma Cells J. Biol. Chem., April 30, 1999; 274(18): 12445 - 12453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gu and D. M. F. Cooper Calmodulin-binding Sites on Adenylyl Cyclase Type VIII J. Biol. Chem., March 19, 1999; 274(12): 8012 - 8021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. F. Cooper, M. J. Schell, P. Thorn, and R. F. Irvine Regulation of Adenylyl Cyclase by Membrane Potential J. Biol. Chem., October 16, 1998; 273(42): 27703 - 27707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Fagan, K. E. Smith, and D. M. F. Cooper Regulation of the Ca2+-inhibitable Adenylyl Cyclase Type VI by Capacitative Ca2+ Entry Requires Localization in Cholesterol-rich Domains J. Biol. Chem., August 18, 2000; 275(34): 26530 - 26537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Fagan, R. A. Graf, S. Tolman, J. Schaack, and D. M. F. Cooper Regulation of a Ca2+-sensitive Adenylyl Cyclase in an Excitable Cell. ROLE OF VOLTAGE-GATED VERSUS CAPACITATIVE Ca2+ ENTRY J. Biol. Chem., December 15, 2000; 275(51): 40187 - 40194. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
