HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hata, D. Articles by Kawakami, T. Search for Related Content PubMed PubMed Citation Articles by Hata, D. Articles by Kawakami, T. Social Bookmarking                      What's this?

J Biol Chem, Vol. 273, Issue 18, 10979-10987, May 1, 1998

Bruton's Tyrosine Kinase-mediated Interleukin-2 Gene Activation in Mast Cells
DEPENDENCE ON THE c-Jun N-TERMINAL KINASE ACTIVATION PATHWAY

Daisuke Hata, Jiro Kitaura, Stephen E. Hartman, Yuko Kawakami, Takashi Yokota, and Toshiaki Kawakami

From the Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, California 92121 and the  Department of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan

Cross-linking of the high affinity IgE receptor (FcRI) on mast cells induces secretion of cytokines, including interleukin (IL)-2, through transcriptional activation of cytokine genes. Previously, defects in the gene coding for Bruton's tyrosine kinase (Btk) were shown to result in defective cytokine production in mast cells, and thereby mice carrying btk mutations exhibited diminished anaphylactic reactions in response to IgE and antigen. In this study, we provide evidence that the transcription factors involved in the IL-2 gene expression in T cells are also required for maximal activation of the IL-2 gene in FcRI-stimulated mast cells. Among them, AP-1 (Jun/Fos) and NF-AT were identified as candidate transcription factors that are regulated by Btk. Consistent with our previous data indicating that Btk regulates stress-activated protein kinases, c-Jun N-terminal kinase (JNK), c-Jun and other JNK-regulatable transcription factors are activated by FcRI cross-linking in a Btk-dependent manner. Further, FcRI-induced IL-2 gene activation is dependent on c-Jun and a component, SEK1, of its upstream activation pathway. Collectively, these data demonstrate that Btk regulates the transcription of the IL-2 gene through the JNK-regulatable transcription factors in FcRI-stimulated mast cells.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				H. Hong, J. Kitaura, W. Xiao, V. Horejsi, C. Ra, C. A. Lowell, Y. Kawakami, and T. Kawakami The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn Blood, October 1, 2007; 110(7): 2511 - 2519. [Abstract] [Full Text] [PDF]

				J. Kitaura, Y. Kawakami, M. Maeda-Yamamoto, V. Horejsi, and T. Kawakami Dysregulation of Src Family Kinases in Mast Cells from Epilepsy-Resistant ASK versus Epilepsy-Prone EL Mice J. Immunol., January 1, 2007; 178(1): 455 - 462. [Abstract] [Full Text] [PDF]

				S. Iwaki, C. Tkaczyk, A. B. Satterthwaite, K. Halcomb, M. A. Beaven, D. D. Metcalfe, and A. M. Gilfillan Btk Plays a Crucial Role in the Amplification of Fc{epsilon}RI-mediated Mast Cell Activation by Kit J. Biol. Chem., December 2, 2005; 280(48): 40261 - 40270. [Abstract] [Full Text] [PDF]

				M. A. Yui, L. L. Sharp, W. L. Havran, and E. V. Rothenberg Preferential Activation of an IL-2 Regulatory Sequence Transgene in TCR{gamma}{delta} and NKT Cells: Subset-Specific Differences in IL-2 Regulation J. Immunol., April 15, 2004; 172(8): 4691 - 4699. [Abstract] [Full Text] [PDF]

				M. Maeda-Yamamoto, N. Inagaki, J. Kitaura, T. Chikumoto, H. Kawahara, Y. Kawakami, M. Sano, T. Miyase, H. Tachibana, H. Nagai, et al. O-Methylated Catechins from Tea Leaves Inhibit Multiple Protein Kinases in Mast Cells J. Immunol., April 1, 2004; 172(7): 4486 - 4492. [Abstract] [Full Text] [PDF]

				J. Kitaura, J. Song, M. Tsai, K. Asai, M. Maeda-Yamamoto, A. Mocsai, Y. Kawakami, F.-T. Liu, C. A. Lowell, B. G. Barisas, et al. Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the Fc{epsilon}RI PNAS, October 28, 2003; 100(22): 12911 - 12916. [Abstract] [Full Text] [PDF]

				F. M. Uckun, Y. Zheng, M. Cetkovic-Cvrlje, A. Vassilev, E. Lisowski, B. Waurzyniak, H. Chen, R. Carpenter, and C.-L. Chen In Vivo Pharmacokinetic Features, Toxicity Profile, and Chemosensitizing Activity of {alpha}-Cyano-{beta}-hydroxy-{beta}- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a Novel Antileukemic Agent Targeting Bruton's Tyrosine Kinase Clin. Cancer Res., May 1, 2002; 8(5): 1224 - 1233. [Abstract] [Full Text] [PDF]

				C. K. Oh, S. G. Filler, and S. H. Cho Eukaryotic Translation Initiation Factor-6 Enhances Histamine and IL-2 Production in Mast Cells J. Immunol., March 1, 2001; 166(5): 3606 - 3611. [Abstract] [Full Text] [PDF]

				Y. Kawakami, J. Kitaura, A. B. Satterthwaite, R. M. Kato, K. Asai, S. E. Hartman, M. Maeda-Yamamoto, C. A. Lowell, D. J. Rawlings, O. N. Witte, et al. Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation J. Immunol., August 1, 2000; 165(3): 1210 - 1219. [Abstract] [Full Text] [PDF]

				Y. Kawakami, J. Kitaura, S. E. Hartman, C. A. Lowell, R. P. Siraganian, and T. Kawakami Regulation of protein kinase Cbeta I by two protein-tyrosine kinases, Btk and Syk PNAS, June 13, 2000; (2000) 120175097. [Abstract] [Full Text]

				M. Saxena, S. Williams, J. Brockdorff, J. Gilman, and T. Mustelin Inhibition of T Cell Signaling by Mitogen-activated Protein Kinase-targeted Hematopoietic Tyrosine Phosphatase (HePTP) J. Biol. Chem., April 23, 1999; 274(17): 11693 - 11700. [Abstract] [Full Text] [PDF]

				Y. Kawakami, S. E. Hartman, E. Kinoshita, H. Suzuki, J. Kitaura, L. Yao, N. Inagaki, A. Franco, D. Hata, M. Maeda-Yamamoto, et al. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase PNAS, March 2, 1999; 96(5): 2227 - 2232. [Abstract] [Full Text] [PDF]

				Y. Kawakami, S. E. Hartman, P. M. Holland, J. A. Cooper, and T. Kawakami Multiple Signaling Pathways for the Activation of JNK in Mast Cells: Involvement of Bruton's Tyrosine Kinase, Protein Kinase C, and JNK Kinases, SEK1 and MKK7 J. Immunol., August 15, 1998; 161(4): 1795 - 1802. [Abstract] [Full Text] [PDF]

				J. Deng, Y. Kawakami, S. E. Hartman, T. Satoh, and T. Kawakami Involvement of Ras in Bruton's Tyrosine Kinase-mediated JNK Activation J. Biol. Chem., July 3, 1998; 273(27): 16787 - 16791. [Abstract] [Full Text] [PDF]

				A. Alonso, M. Saxena, S. Williams, and T. Mustelin Inhibitory Role for Dual Specificity Phosphatase VHR in T Cell Antigen Receptor and CD28-induced Erk and Jnk Activation J. Biol. Chem., February 9, 2001; 276(7): 4766 - 4771. [Abstract] [Full Text] [PDF]

				A. J. Mohamed, L. Vargas, B. F. Nore, C.-M. Backesjo, B. Christensson, and C. I. E. Smith Nucleocytoplasmic Shuttling of Bruton's Tyrosine Kinase J. Biol. Chem., December 15, 2000; 275(51): 40614 - 40619. [Abstract] [Full Text] [PDF]

				T.-T. Ching, A.-L. Hsu, A. J. Johnson, and C.-S. Chen Phosphoinositide 3-Kinase Facilitates Antigen-stimulated Ca2+ Influx in RBL-2H3 Mast Cells via a Phosphatidylinositol 3,4,5-Trisphosphate-sensitive Ca2+ Entry Mechanism J. Biol. Chem., April 27, 2001; 276(18): 14814 - 14820. [Abstract] [Full Text] [PDF]

				S. Mahajan, A. Vassilev, N. Sun, Z. Ozer, C. Mao, and F. M. Uckun Transcription Factor STAT5A Is a Substrate of Bruton's Tyrosine Kinase in B Cells J. Biol. Chem., August 10, 2001; 276(33): 31216 - 31228. [Abstract] [Full Text] [PDF]

				Y. Kawakami, J. Kitaura, S. E. Hartman, C. A. Lowell, R. P. Siraganian, and T. Kawakami Regulation of protein kinase Cbeta I by two protein-tyrosine kinases, Btk and Syk PNAS, June 20, 2000; 97(13): 7423 - 7428. [Abstract] [Full Text] [PDF]