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J Biol Chem, Vol. 273, Issue 19, 11401-11404, May 8, 1998
From the Department of Biochemistry, Emory University School of
Medicine, Atlanta, Georgia 30322
Activation of apoptosis is associated with
generation of reactive oxygen species. The present research shows that
superoxide is produced by mitochondria isolated from apoptotic cells
due to a switch from the normal 4-electron reduction of
O2 to a 1-electron reduction when cytochrome
c is released from mitochondria. Bcl-2, a protein that
protects against apoptosis and blocks cytochrome c release,
prevents superoxide production when it is overexpressed. The switch in
electron transfer provides a mechanism for redox signaling that is
concomitant with cytochrome c-dependent
activation of caspases. The block of cytochrome c release
provides a mechanism for the apparent antioxidant function of
Bcl-2.
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