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J Biol Chem, Vol. 273, Issue 20, 12128-12134, May 15, 1998
From the Changes in mean arterial pressure were monitored
in rats following 50% isovolemic exchange transfusion with solutions
of chemically modified hemoglobins. Blood pressure responses fall into
three categories: 1) an immediate and sustained increase, 2) an
immediate yet transient increase, or 3) no significant change either
during or subsequent to exchange transfusion. The reactivities of these hemoglobins with nitric monoxide (·NO) were measured to test the
hypothesis that different blood pressure responses to these solutions
result from differences in ·NO scavenging reactions. All
hemoglobins studied exhibited a value of 30 µM
Arterial Blood Pressure Responses to Cell-free Hemoglobin
Solutions and the Reaction with Nitric Oxide
,,,,,, and
Department of Medicine, School of Medicine,
University of California, San Diego, Veterans Affairs Medical
Center, San Diego, California 92161 and ¶ Department of Chemistry
and Biochemistry, University of California, San Diego, La Jolla,
California 92093
1 s1 for both
·NO bimolecular association rate constants and the rate
constants for ·NO-induced oxidation in vitro. Only
the ·NO dissociation rate constants and, thus, the equilibrium
dissociation constants varied. Values of equilibrium dissociation
constants ranged from 2 to 14 pM and varied inversely with
vasopressor response. Hemoglobin solutions that exhibited either
transient or no significant increase in blood pressure showed tighter
·NO binding affinities than hemoglobin solutions that exhibited sustained increases. These results suggest that blood pressure increases observed upon exchange transfusion with cell-free hemoglobin solutions can not be the result of ·NO scavenging reactions at
the heme, but rather must be due to alternative physiologic
mechanisms.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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