| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 22, 13430-13436, May 29, 1998
From the Institut de Biologie de Lille (IFR3), Institut Pasteur de
Lille, 59021 Lille, France and § Laboratory of Fundamental
Virology, Institute of Pathology, University of Liège, B-4000
Liège, Belgium
The varicella-zoster virus (VZV) is the
etiological agent of two different human pathologies, chickenpox
(varicella) and shingles (zoster). This alphaherpesvirus is believed to
acquire its lipidic envelope in the trans-Golgi network (TGN). This is
consistent with previous data showing that the most abundant VZV
envelope glycoprotein gE accumulates at steady-state in this organelle when expressed from cloned cDNA. In the present study, we have investigated the intracellular trafficking of gI, another VZV envelope
glycoprotein. In transfected cells, this protein shows a very slow
biosynthetic transport to the cell surface where it accumulates.
However, upon co-expression of gE, gI experiences a dramatic increase
in its exit rate from the endoplasmic reticulum, it accumulates in a
sialyltransferase-positive compartment, presumably the TGN, and cycles
between this compartment and the cell surface. This differential
behavior results from the ability of gE and gI to form a complex in the
early stages of the biosynthetic pathway whose intracellular traffic is
exclusively determined by the sorting information in the tail of gE.
Thus, gI provides the first example of a molecule localized to the TGN
by means of its association with another TGN protein. We also show
that, during the early stages of VZV infection, both proteins are also
found in the TGN of the host cell. This suggests the existence of an
intermediate stage during VZV biogenesis in which the envelope
glycoproteins, transiently arrested in the TGN, could promote the
envelopment of newly synthesized nucleocapsids into this compartment
and, therefore, the assembly of infective viruses.
This article has been cited by other articles:
|
|
 |
|
  I. Beitia Ortiz de Zarate, L. Cantero-Aguilar, M. Longo, C. Berlioz-Torrent, and F. Rozenberg Contribution of Endocytic Motifs in the Cytoplasmic Tail of Herpes Simplex Virus Type 1 Glycoprotein B to Virus Replication and Cell-Cell Fusion J. Virol., December 15, 2007; 81(24): 13889 - 13903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Lee, J. W. Murray, A. W. Wolkoff, and D. W. Wilson Reconstitution of Herpes Simplex Virus Microtubule-Dependent Trafficking In Vitro J. Virol., May 1, 2006; 80(9): 4264 - 4275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Cohrs, D. H. Gilden, Y. Gomi, K. Yamanishi, and J. I. Cohen Comparison of Virus Transcription during Lytic Infection of the Oka Parental and Vaccine Strains of Varicella-Zoster Virus J. Virol., March 1, 2006; 80(5): 2076 - 2082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Turcotte, J. Letellier, and R. Lippe Herpes Simplex Virus Type 1 Capsids Transit by the trans-Golgi Network, Where Viral Glycoproteins Accumulate Independently of Capsid Egress J. Virol., July 15, 2005; 79(14): 8847 - 8860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Maresova, T. J. Pasieka, E. Homan, E. Gerday, and C. Grose Incorporation of Three Endocytosed Varicella-Zoster Virus Glycoproteins, gE, gH, and gB, into the Virion Envelope J. Virol., January 15, 2005; 79(2): 997 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Moffat, C. Mo, J. J. Cheng, M. Sommer, L. Zerboni, S. Stamatis, and A. M. Arvin Functions of the C-Terminal Domain of Varicella-Zoster Virus Glycoprotein E in Viral Replication In Vitro and Skin and T-Cell Tropism In Vivo J. Virol., November 15, 2004; 78(22): 12406 - 12415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sato, H. Ito, S. Hinchliffe, M. H. Sommer, L. Zerboni, and A. M. Arvin Mutational Analysis of Open Reading Frames 62 and 71, Encoding the Varicella-Zoster Virus Immediate-Early Transactivating Protein, IE62, and Effects on Replication In Vitro and in Skin Xenografts in the SCID-hu Mouse In Vivo J. Virol., May 15, 2003; 77(10): 5607 - 5620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Brignati, J. S. Loomis, J. W. Wills, and R. J. Courtney Membrane Association of VP22, a Herpes Simplex Virus Type 1 Tegument Protein J. Virol., April 15, 2003; 77(8): 4888 - 4898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Pasieka, L. Maresova, and C. Grose A Functional YNKI Motif in the Short Cytoplasmic Tail of Varicella-Zoster Virus Glycoprotein gH Mediates Clathrin-Dependent and Antibody-Independent Endocytosis J. Virol., April 1, 2003; 77(7): 4191 - 4204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ito, M. H. Sommer, L. Zerboni, H. He, D. Boucaud, J. Hay, W. Ruyechan, and A. M. Arvin Promoter Sequences of Varicella-Zoster Virus Glycoprotein I Targeted by Cellular Transactivating Factors Sp1 and USF Determine Virulence in Skin and T Cells in SCIDhu Mice In Vivo J. Virol., December 6, 2002; 77(1): 489 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Foster, X. Alvarez, and K. G. Kousoulas Plasma Membrane Topology of Syncytial Domains of Herpes Simplex Virus Type 1 Glycoprotein K (gK): the UL20 Protein Enables Cell Surface Localization of gK but Not gK-Mediated Cell-to-Cell Fusion J. Virol., December 6, 2002; 77(1): 499 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Moffat, H. Ito, M. Sommer, S. Taylor, and A. M. Arvin Glycoprotein I of Varicella-Zoster Virus Is Required for Viral Replication in Skin and T Cells J. Virol., July 17, 2002; 76(16): 8468 - 8471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Schumacher, B. K. Tischer, S. M. Reddy, and N. Osterrieder Glycoproteins E and I of Marek's Disease Virus Serotype 1 Are Essential for Virus Growth in Cultured Cells J. Virol., December 1, 2001; 75(23): 11307 - 11318. [Abstract] [Full Text]
|
|
|
|
|
|
Z.-H. Wang, M. D. Gershon, O. Lungu, Z. Zhu, S. Mallory, A. M. Arvin, and A. A. Gershon Essential Role Played by the C-Terminal Domain of Glycoprotein I in Envelopment of Varicella-Zoster Virus in the trans-Golgi Network: Interactions of Glycoproteins with Tegument J. Virol., January 1, 2001; 75(1): 323 - 340. [Abstract] [Full Text]
|
|
|
|
|
|
C. Mo, E. E. Schneeberger, and A. M. Arvin Glycoprotein E of Varicella-Zoster Virus Enhances Cell-Cell Contact in Polarized Epithelial Cells J. Virol., December 1, 2000; 74(23): 11377 - 11387. [Abstract] [Full Text]
|
|
|
|
|
|
Z.-H. Wang, M. D. Gershon, O. Lungu, Z. Zhu, and A. A. Gershon Trafficking of Varicella-Zoster Virus Glycoprotein gI: T338-Dependent Retention in the trans-Golgi Network, Secretion, and Mannose 6-Phosphate-Inhibitable Uptake of the Ectodomain J. Virol., July 15, 2000; 74(14): 6600 - 6613. [Abstract] [Full Text]
|
|
|
|
|
|
A. D. Brideau, M. G. Eldridge, and L. W. Enquist Directional Transneuronal Infection by Pseudorabies Virus Is Dependent on an Acidic Internalization Motif in the Us9 Cytoplasmic Tail J. Virol., May 15, 2000; 74(10): 4549 - 4561. [Abstract] [Full Text]
|
|
|
|
|
|
C. Mo, J. Suen, M. Sommer, and A. Arvin Characterization of Varicella-Zoster Virus Glycoprotein K (Open Reading Frame 5) and Its Role in Virus Growth J. Virol., May 1, 1999; 73(5): 4197 - 4207. [Abstract] [Full Text]
|
|
|
|
|
|
A. D. Brideau, T. del Rio, E. J. Wolffe, and L. W. Enquist Intracellular Trafficking and Localization of the Pseudorabies Virus Us9 Type II Envelope Protein to Host and Viral Membranes J. Virol., May 1, 1999; 73(5): 4372 - 4384. [Abstract] [Full Text]
|
|
|
|
|
|
R. S. Tirabassi and L. W. Enquist Mutation of the YXXL Endocytosis Motif in the Cytoplasmic Tail of Pseudorabies Virus gE J. Virol., April 1, 1999; 73(4): 2717 - 2728. [Abstract] [Full Text]
|
|
|
|
|
|
A. Alconada, U. Bauer, B. Sodeik, and B. Hoflack Intracellular Traffic of Herpes Simplex Virus Glycoprotein gE: Characterization of the Sorting Signals Required for Its trans-Golgi Network Localization J. Virol., January 1, 1999; 73(1): 377 - 387. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
