| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 25, 15340-15344, June 19, 1998
From the Division of Cell Biology, La Jolla Institute for Allergy
and Immunology, San Diego, California 92121
The hematopoietic tyrosine phosphatase (HePTP) is
predominantly expressed in thymocytes and T lymphocytes and at lower
levels in other hematopoietic cells. Expression of the gene is enhanced by the T cell growth factor interleukin-2, suggesting a role for HePTP
in T cell proliferation or differentiation. We report that HePTP blocks
T cell antigen receptor (TCR)-induced transcriptional activation of a
reporter gene driven by a nuclear factor of activated T
cells(NFAT)/AP-1 element taken from the interleukin-2 gene promoter. This effect was specific to HePTP and was abolished by a mutation (C270S) that impaired its phosphatase activity. Co-expression of HePTP
also reduced TCR-induced activation of the mitogen-activated protein
kinase Erk2 and the TCR-induced appearance of phosphorylated Erk. In
contrast, HePTP did not affect the activation of the N-terminal c-Jun
kinase, Jnk. Together these findings suggest that HePTP plays an active
negative role in TCR signaling by dephosphorylating one or several
signaling molecules between the receptor and the mitogen-activated
protein kinase pathway.
This article has been cited by other articles:
|
|
 |
|
  K. Nika, C. Charvet, S. Williams, L. Tautz, S. Bruckner, S. Rahmouni, N. Bottini, S. P. Schoenberger, G. Baier, A. Altman, et al. Lipid Raft Targeting of Hematopoietic Protein Tyrosine Phosphatase by Protein Kinase C {theta}-Mediated Phosphorylation. Mol. Cell. Biol., March 1, 2006; 26(5): 1806 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Huang, B. Zhou, and Z.-Y. Zhang Molecular Determinants of Substrate Recognition in Hematopoietic Protein-tyrosine Phosphatase J. Biol. Chem., December 10, 2004; 279(50): 52150 - 52159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Huynh, X. Wang, W. Li, N. Bottini, S. Williams, K. Nika, H. Ishihara, A. Godzik, and T. Mustelin Homotypic Secretory Vesicle Fusion Induced by the Protein Tyrosine Phosphatase MEG2 Depends on Polyphosphoinositides in T Cells J. Immunol., December 15, 2003; 171(12): 6661 - 6671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Barat and M. J. Tremblay Treatment of Human T Cells with Bisperoxovanadium Phosphotyrosyl Phosphatase Inhibitors Leads to Activation of Cyclooxygenase-2 Gene J. Biol. Chem., February 21, 2003; 278(9): 6992 - 7000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhu, T. Mustelin, and M. David Arginine Methylation of STAT1 Regulates Its Dephosphorylation by T Cell Protein Tyrosine Phosphatase J. Biol. Chem., September 20, 2002; 277(39): 35787 - 35790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhou, Z.-X. Wang, Y. Zhao, D. L. Brautigan, and Z.-Y. Zhang The Specificity of Extracellular Signal-regulated Kinase 2 Dephosphorylation by Protein Phosphatases J. Biol. Chem., August 23, 2002; 277(35): 31818 - 31825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Buschbeck, J. Eickhoff, M. N. Sommer, and A. Ullrich Phosphotyrosine-specific Phosphatase PTP-SL Regulates the ERK5 Signaling Pathway J. Biol. Chem., August 9, 2002; 277(33): 29503 - 29509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shen, Y.-B. Ouyang, C.-K. Qu, A. Alonso, L. Sperzel, T. Mustelin, M. H. Kaplan, and G.-S. Feng Grap Negatively Regulates T-Cell Receptor-Elicited Lymphocyte Proliferation and Interleukin-2 Induction Mol. Cell. Biol., May 15, 2002; 22(10): 3230 - 3236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, H. Huynh, A. Gjorloff-Wingren, E. Monosov, M. Stridsberg, M. Fukuda, and T. Mustelin Enlargement of Secretory Vesicles by Protein Tyrosine Phosphatase PTP-MEG2 in Rat Basophilic Leukemia Mast Cells and Jurkat T Cells J. Immunol., May 1, 2002; 168(9): 4612 - 4619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gronda, S. Arab, B. Iafrate, H. Suzuki, and B. W. Zanke Hematopoietic Protein Tyrosine Phosphatase Suppresses Extracellular Stimulus-Regulated Kinase Activation Mol. Cell. Biol., October 15, 2001; 21(20): 6851 - 6858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Oh-hora, M. Ogata, Y. Mori, M. Adachi, K. Imai, A. Kosugi, and T. Hamaoka Direct Suppression of TCR-Mediated Activation of Extracellular Signal-Regulated Kinase by Leukocyte Protein Tyrosine Phosphatase, a Tyrosine-Specific Phosphatase J. Immunol., August 1, 1999; 163(3): 1282 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zuniga, J. Torres, J. Ubeda, and R. Pulido Interaction of Mitogen-activated Protein Kinases with the Kinase Interaction Motif of the Tyrosine Phosphatase PTP-SL Provides Substrate Specificity and Retains ERK2 in the Cytoplasm J. Biol. Chem., July 30, 1999; 274(31): 21900 - 21907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saxena, S. Williams, J. Brockdorff, J. Gilman, and T. Mustelin Inhibition of T Cell Signaling by Mitogen-activated Protein Kinase-targeted Hematopoietic Tyrosine Phosphatase (HePTP) J. Biol. Chem., April 23, 1999; 274(17): 11693 - 11700. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
