| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 25, 15540-15545, June 19, 1998
-Fodrin Cleavage but Dispensable for
Cleavage of Other Death Substrates in Apoptosis
From the Institute of Molecular and Cell Biology, The National
University of Singapore, 30 Medical Dr., Singapore 117609, Republic
of Singapore
Although the commonly activated death protease
caspase-3 appears not to be essential for apoptosis during development
except in the brain, it was not shown whether substrates known to be cleaved by caspase-3 are still proteolyzed in its absence. We have
addressed this question with MCF-7 breast carcinoma cells that we
recently showed lack caspase-3 owing to the functional deletion of the
CASP-3 gene. Tumor necrosis factor- or
staurosporine-induced apoptosis of caspase-3-deficient MCF-7 cells
resulted in cleavage of the death substrates PARP, Rb, PAK2,
DNA-PKcs, gelsolin, and DFF-45, but not 
-fodrin. In
contrast, all these substrates including -fodrin were cleaved in
apoptotic HeLa cells expressing caspase-3. Introduction of
CASP-3 cDNA, but not CASP-10 cDNA, into
MCF-7 cells restored -fodrin cleavage. In addition, tumor necrosis factor- or staurosporine-induced apoptosis of MCF-7 cells stably expressing pro-caspase-3 also resulted in -fodrin cleavage. Although the specific caspase inhibitory peptides Z-VAD-fmk and Z-DEVD-fmk prevented apoptosis of MCF-7 cells, we were unable to detect activation of caspases 2 and 7, which are known to be inhibited by Z-DEVD-fmk. Together our results suggest that caspase-3 is essential for cleavage of -fodrin, but dispensable for the cleavage of PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45 and imply that one or more
caspases other than caspases 2, 3, and 7 is activated and plays a
crucial role in the cleavage of these substrates in MCF-7 cells.
This article has been cited by other articles:
|
|
 |
|
  S. Solinet and M. L. Vitale Isoform B of myosin II heavy chain mediates actomyosin contractility during TNF{alpha}-induced apoptosis J. Cell Sci., May 15, 2008; 121(10): 1681 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mazroui, S. Di Marco, E. Clair, C. von Roretz, S. A. Tenenbaum, J. D. Keene, M. Saleh, and I.-E. Gallouzi Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis J. Cell Biol., January 10, 2008; 180(1): 113 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Gdynia, K. Grund, A. Eckert, B. C. Bock, B. Funke, S. Macher-Goeppinger, S. Sieber, C. Herold-Mende, B. Wiestler, O. D. Wiestler, et al. Basal Caspase Activity Promotes Migration and Invasiveness in Glioblastoma Cells Mol. Cancer Res., December 1, 2007; 5(12): 1232 - 1240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kaneko, N. Tsuji, K. Asanuma, H. Tanabe, D. Kobayashi, and N. Watanabe Survivin Down-regulation Plays a Crucial Role in 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitor-induced Apoptosis in Cancer J. Biol. Chem., July 6, 2007; 282(27): 19273 - 19281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Roukos, M. S. Iliou, H. Nishitani, M. Gentzel, M. Wilm, S. Taraviras, and Z. Lygerou Geminin Cleavage during Apoptosis by Caspase-3 Alters Its Binding Ability to the SWI/SNF Subunit Brahma J. Biol. Chem., March 30, 2007; 282(13): 9346 - 9357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Cullen, C. Adrain, A. U. Luthi, P. J. Duriez, and S. J. Martin Human and murine granzyme B exhibit divergent substrate preferences J. Cell Biol., February 12, 2007; 176(4): 435 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Song, J. Y. An, Y. T. Kwon, and Y. J. Lee Evidence for Two Modes of Development of Acquired Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance: INVOLVEMENT OF Bcl-xL J. Biol. Chem., January 5, 2007; 282(1): 319 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-J. KIM, D.-H. KIM, K. W. LEE, D.-Y. YOON, and Y.-J. SURH Jaceosidin Induces Apoptosis in ras-Transformed Human Breast Epithelial Cells through Generation of Reactive Oxygen Species Ann. N.Y. Acad. Sci., January 1, 2007; 1095(1): 483 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Simonovic, Z. Zhang, C. D. Cianci, T. A. Steitz, and J. S. Morrow Structure of the Calmodulin {alpha}II-Spectrin Complex Provides Insight into the Regulation of Cell Plasticity J. Biol. Chem., November 10, 2006; 281(45): 34333 - 34340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Vallender and B. T. Lahn A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway Hum. Mol. Genet., October 15, 2006; 15(20): 3034 - 3040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Vegran, R. Boidot, C. Oudin, J.-M. Riedinger, F. Bonnetain, and S. Lizard-Nacol Overexpression of caspase-3s splice variant in locally advanced breast carcinoma is associated with poor response to neoadjuvant chemotherapy. Clin. Cancer Res., October 1, 2006; 12(19): 5794 - 5800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Calcabrini, J. M. Garcia-Martinez, L. Gonzalez, M. J. Tendero, M. T. A. Ortuno, P. Crateri, A. Lopez-Rivas, G. Arancia, P. Gonzalez-Porque, and J. Martin-Perez Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate Carcinogenesis, August 1, 2006; 27(8): 1699 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. H. Grus, S. C. Joachim, K. Bruns, K. J. Lackner, N. Pfeiffer, and M. B. Wax Serum Autoantibodies to {alpha}-Fodrin Are Present in Glaucoma Patients from Germany and the United States. Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 968 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sohn, G. Totzke, F. Essmann, K. Schulze-Osthoff, B. Levkau, and R. U. Janicke The proteasome is required for rapid initiation of death receptor-induced apoptosis. Mol. Cell. Biol., March 1, 2006; 26(5): 1967 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Twiddy, G. M. Cohen, M. MacFarlane, and K. Cain Caspase-7 Is Directly Activated by the ~700-kDa Apoptosome Complex and Is Released as a Stable XIAP-Caspase-7 ~200-kDa Complex J. Biol. Chem., February 17, 2006; 281(7): 3876 - 3888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Beier, J. Wischhusen, M. Gleichmann, E. Gerhardt, A. Pekanovic, A. Krueger, V. Taylor, U. Suter, P. H. Krammer, M. Endres, et al. FasL (CD95L/APO-1L) Resistance of Neurons Mediated by Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B-Dependent Expression of Lifeguard/Neuronal Membrane Protein 35 J. Neurosci., July 20, 2005; 25(29): 6765 - 6774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. WITTE Antifodrin Antibodies in Sjogren's Syndrome: A Review Ann. N.Y. Acad. Sci., June 1, 2005; 1051(1): 235 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wesierska-Gadek, M. Gueorguieva, and M. Horky Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells Mol. Cancer Ther., January 1, 2005; 4(1): 113 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wang, S. Ladrech, R. Pujol, P. Brabet, T. R. Van De Water, and J.-L. Puel Caspase Inhibitors, but not c-Jun NH2-Terminal Kinase Inhibitor Treatment, Prevent Cisplatin-Induced Hearing Loss Cancer Res., December 15, 2004; 64(24): 9217 - 9224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Svingen, D. Loegering, J. Rodriquez, X. W. Meng, P. W. Mesner Jr., S. Holbeck, A. Monks, S. Krajewski, D. A. Scudiero, E. A. Sausville, et al. Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel Clin. Cancer Res., October 15, 2004; 10(20): 6807 - 6820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Huppertz and J. C. P. Kingdom Apoptosis in the Trophoblast--Role of Apoptosis in Placental Morphogenesis Reproductive Sciences, September 1, 2004; 11(6): 353 - 362. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Rosati, R. Sabatini, E. Ayroldi, A. Tabilio, A. Bartoli, S. Bruscoli, C. Simoncelli, R. Rossi, and P. Marconi Apoptosis of human primary B lymphocytes is inhibited by N-acetyl-L-cysteine J. Leukoc. Biol., July 1, 2004; 76(1): 152 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Maruyama, I. Saito, Y. Hayashi, E. Kompfner, R. I. Fox, D. R. Burton, and H. J. Ditzel Molecular Analysis of the Human Autoantibody Response to {alpha}-Fodrin in Sjogren's Syndrome Reveals Novel Apoptosis-Induced Specificity Am. J. Pathol., July 1, 2004; 165(1): 53 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Graham, K. E. Gustin, C. Rivera, N. M. Kuyumcu-Martinez, S. S. Choe, R. E. Lloyd, P. Sarnow, and P. J. Utz Proteolytic Cleavage of the Catalytic Subunit of DNA-Dependent Protein Kinase during Poliovirus Infection J. Virol., June 15, 2004; 78(12): 6313 - 6321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bojarski, J. Weiske, T. Schoneberg, W. Schroder, J. Mankertz, J.-D. Schulzke, P. Florian, M. Fromm, R. Tauber, and O. Huber The specific fates of tight junction proteins in apoptotic epithelial cells J. Cell Sci., April 15, 2004; 117(10): 2097 - 2107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yacobi, A. Wojtowicz, A. Tsafriri, and A. Gross Gonadotropins Enhance Caspase-3 and -7 Activity and Apoptosis in the Theca-Interstitial Cells of Rat Preovulatory Follicles in Culture Endocrinology, April 1, 2004; 145(4): 1943 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-S. Kim, A. R. Ingermann, J. Tsubaki, S. M. Twigg, G. E. Walker, and Y. Oh Insulin-Like Growth Factor-Binding Protein 3 Induces Caspase-Dependent Apoptosis through a Death Receptor-Mediated Pathway in MCF-7 Human Breast Cancer Cells Cancer Res., March 15, 2004; 64(6): 2229 - 2237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-E. Kim and S. R. Tannenbaum S-Nitrosation Regulates the Activation of Endogenous Procaspase-9 in HT-29 Human Colon Carcinoma Cells J. Biol. Chem., March 12, 2004; 279(11): 9758 - 9764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Qin, D. Morrow, J. Stewart, K. Spencer, W. Porter, R. Smith III, T. Phillips, M. Abdelrahim, I. Samudio, and S. Safe A new class of peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes Mol. Cancer Ther., March 1, 2004; 3(3): 247 - 260. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. J. Kaiser, J. L. Kaufman, and M. K. Offermann IFN-{alpha} Sensitizes Human Umbilical Vein Endothelial Cells to Apoptosis Induced by Double-Stranded RNA J. Immunol., February 1, 2004; 172(3): 1699 - 1710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Methot, J. Huang, N. Coulombe, J. P. Vaillancourt, D. Rasper, J. Tam, Y. Han, J. Colucci, R. Zamboni, S. Xanthoudakis, et al. Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics J. Exp. Med., January 20, 2004; 199(2): 199 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Korfali, S. Ruchaud, D. Loegering, D. Bernard, C. Dingwall, S. H. Kaufmann, and W. C. Earnshaw Caspase-7 Gene Disruption Reveals an Involvement of the Enzyme during the Early Stages of Apoptosis J. Biol. Chem., January 9, 2004; 279(2): 1030 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Guimaraes, M. Benchimol, G. P. Amarante-Mendes, and R. Linden Alternative Programs of Cell Death in Developing Retinal Tissue J. Biol. Chem., October 24, 2003; 278(43): 41938 - 41946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. CADET, S. JAYANTHI, and X. DENG Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis FASEB J, October 1, 2003; 17(13): 1775 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Townsend, R. I. Cutress, A. Sharp, M. Brimmell, and G. Packham BAG-1 Prevents Stress-induced Long-term Growth Inhibition in Breast Cancer Cells via a Chaperone-dependent Pathway Cancer Res., July 15, 2003; 63(14): 4150 - 4157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wang, M. Nguyen, D. G. Breckenridge, M. Stojanovic, P. A. Clemons, S. Kuppig, and G. C. Shore Uncleaved BAP31 in Association with A4 Protein at the Endoplasmic Reticulum Is an Inhibitor of Fas-initiated Release of Cytochrome c from Mitochondria J. Biol. Chem., April 11, 2003; 278(16): 14461 - 14468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Taimen and M. Kallajoki NuMA and nuclear lamins behave differently in Fas-mediated apoptosis J. Cell Sci., February 1, 2003; 116(3): 571 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Vanden Hoek, Y. Qin, K. Wojcik, C.-Q. Li, Z.-H. Shao, T. Anderson, L. B. Becker, and K. J. Hamann Reperfusion, not simulated ischemia, initiates intrinsic apoptosis injury in chick cardiomyocytes Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H141 - H150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Lee, O. Schickling, A. H. Stegh, R. G. Oshima, D. Dinsdale, G. M. Cohen, and M. E. Peter DEDD regulates degradation of intermediate filaments during apoptosis J. Cell Biol., September 16, 2002; 158(6): 1051 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Saegusa, N. Ishimaru, K. Yanagi, K. Mishima, R. Arakaki, T. Suda, I. Saito, and Y. Hayashi Prevention and Induction of Autoimmune Exocrinopathy Is Dependent on Pathogenic Autoantigen Cleavage in Murine Sjogren's Syndrome J. Immunol., July 15, 2002; 169(2): 1050 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rehm, H. Dussmann, R. U. Janicke, J. M. Tavare, D. Kogel, and J. H. M. Prehn Single-cell Fluorescence Resonance Energy Transfer Analysis Demonstrates That Caspase Activation during Apoptosis Is a Rapid Process. ROLE OF CASPASE-3 J. Biol. Chem., June 28, 2002; 277(27): 24506 - 24514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. McKinnon, D. M. Lehman, L. A. Kerrigan-Baumrind, C. A. Merges, M. E. Pease, D. F. Kerrigan, N. L. Ransom, N. G. Tahzib, H. A. Reitsamer, H. Levkovitch-Verbin, et al. Caspase Activation and Amyloid Precursor Protein Cleavage in Rat Ocular Hypertension Invest. Ophthalmol. Vis. Sci., April 1, 2002; 43(4): 1077 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. W. Jeffrey, M. Bushell, V. J. Tilleray, S. Morley, and M. J. Clemens Inhibition of Protein Synthesis in Apoptosis: Differential Requirements by the Tumor Necrosis Factor {alpha} Family and a DNA-damaging Agent for Caspases and the Double-stranded RNA-dependent Protein Kinase Cancer Res., April 1, 2002; 62(8): 2272 - 2280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Stegh, B. C. Barnhart, J. Volkland, A. Algeciras-Schimnich, N. Ke, J. C. Reed, and M. E. Peter Inactivation of Caspase-8 on Mitochondria of Bcl-xL-expressing MCF7-Fas Cells. ROLE FOR THE BIFUNCTIONAL APOPTOSIS REGULATOR PROTEIN J. Biol. Chem., February 1, 2002; 277(6): 4351 - 4360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Kottke, A. L. Blajeski, X. W. Meng, P. A. Svingen, S. Ruchaud, P. W. Mesner Jr., S. A. Boerner, K. Samejima, N. V. Henriquez, T. J. Chilcote, et al. Lack of Correlation between Caspase Activation and Caspase Activity Assays in Paclitaxel-treated MCF-7 Breast Cancer Cells J. Biol. Chem., January 4, 2002; 277(1): 804 - 815. [Abstract] [Full Text]
|
|
|
|
|
|
K. W. Crawford and W. D. Bowen Sigma-2 Receptor Agonists Activate a Novel Apoptotic Pathway and Potentiate Antineoplastic Drugs in Breast Tumor Cell Lines Cancer Res., January 1, 2002; 62(1): 313 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bantel, B. Sinha, W. Domschke, G. Peters, K. Schulze-Osthoff, and R. U. Janicke {alpha}-Toxin is a mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling J. Cell Biol., November 12, 2001; 155(4): 637 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. J. Kim, Y. Yi, E. Sapp, Y. Wang, B. Cuiffo, K. B. Kegel, Z.-H. Qin, N. Aronin, and M. DiFiglia Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis PNAS, October 23, 2001; 98(22): 12784 - 12789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Oppenheim, R. A. Flavell, S. Vinsant, D. Prevette, C.-Y. Kuan, and P. Rakic Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases J. Neurosci., July 1, 2001; 21(13): 4752 - 4760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matikainen, G. I. Perez, T. S. Zheng, T. R. Kluzak, B. R. Rueda, R. A. Flavell, and J. L. Tilly Caspase-3 Gene Knockout Defines Cell Lineage Specificity for Programmed Cell Death Signaling in the Ovary Endocrinology, June 1, 2001; 142(6): 2468 - 2480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kagawa, J. Gu, T. Honda, T. J. McDonnell, S. G. Swisher, J. A. Roth, and B. Fang Deficiency of Caspase-3 in MCF7 Cells Blocks Bax-mediated Nuclear Fragmentation but not Cell Death Clin. Cancer Res., May 1, 2001; 7(5): 1474 - 1480. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. M. Mc Gee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler, D. C. Williams, and D. M. Zisterer Pyrrolo-1,5-benzoxazepines Induce Apoptosis in Chronic Myelogenous Leukemia (CML) Cells by Bypassing the Apoptotic Suppressor Bcr-Abl J. Pharmacol. Exp. Ther., January 1, 2001; 296(1): 31 - 40. [Abstract] [Full Text]
|
|
|
|
|
|
T. T. Rohn, E. Head, J. H. Su, A. J. Anderson, B. A. Bahr, C. W. Cotman, and D. H. Cribbs Correlation between Caspase Activation and Neurofibrillary Tangle Formation in Alzheimer's Disease Am. J. Pathol., January 1, 2001; 158(1): 189 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Stegh, H. Herrmann, S. Lampel, D. Weisenberger, K. Andrä, M. Seper, G. Wiche, P. H. Krammer, and M. E. Peter Identification of the Cytolinker Plectin as a Major Early In Vivo Substrate for Caspase 8 during CD95- and Tumor Necrosis Factor Receptor-Mediated Apoptosis Mol. Cell. Biol., August 1, 2000; 20(15): 5665 - 5679. [Abstract] [Full Text]
|
|
|
|
|
|
C. Blanc, Q. L. Deveraux, S. Krajewski, R. U. Jänicke, A. G. Porter, J. C. Reed, R. Jaggi, and A. Marti Caspase-3 Is Essential for Procaspase-9 Processing and Cisplatin-induced Apoptosis of MCF-7 Breast Cancer Cells Cancer Res., August 1, 2000; 60(16): 4386 - 4390. [Abstract] [Full Text]
|
|
|
|
|
|
M. Barry, J. A. Heibein, M. J. Pinkoski, S.-F. Lee, R. W. Moyer, D. R. Green, and R. C. Bleackley Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid Mol. Cell. Biol., June 1, 2000; 20(11): 3781 - 3794. [Abstract] [Full Text]
|
|
|
|
|
|
C.-R. Yang, K. Leskov, K. Hosley-Eberlein, T. Criswell, J. J. Pink, T. J. Kinsella, and D. A. Boothman Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death PNAS, May 23, 2000; 97(11): 5907 - 5912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tang, J. M. Lahti, and V. J. Kidd Caspase-8 Activation and Bid Cleavage Contribute to MCF7 Cellular Execution in a Caspase-3-dependent Manner during Staurosporine-mediated Apoptosis J. Biol. Chem., March 24, 2000; 275(13): 9303 - 9307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Subauste, M. Von Herrath, V. Benard, C. E. Chamberlain, T.-H. Chuang, K. Chu, G. M. Bokoch, and K. M. Hahn Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and Fas J. Biol. Chem., March 24, 2000; 275(13): 9725 - 9733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
