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J Biol Chem, Vol. 273, Issue 25, 15854-15859, June 19, 1998
From the Research Institute, Osaka Medical Center for Maternal and
Child Health, 840 Murodo, Izumi, Osaka 594-1101, Japan
A panel of human tumor cell lines was screened
for selective expression of laminin
Isolation and Characterization of Laminin-10/11 Secreted by
Human Lung Carcinoma Cells
LAMININ-10/11 MEDIATES CELL ADHESION THROUGH INTEGRIN
3
1
5 chain, a newly identified
laminin subunit comprising laminin-10 (51
1) and -11 (521). The lung adenocarcinoma cell line A549 was found to
express the 5 chain at relatively high levels but no detectable
amounts of other chains. The laminin variants containing 5 chain
were purified from the conditioned medium of A549 cells by
immunoaffinity chromatography using the anti-laminin monoclonal
antibody 4C7 which was shown recently to recognize the laminin 5
chain (Tiger, C.-F., Champliaud, M.-F., Pedrosa-Domellof, F., Thornell,
L.-E., Ekblom, P., and Gullberg, D. (1997) J. Biol.
Chem. 272, 28590-28595). The purified laminin variants consisted
of three chains with molecular masses of 350, 220, and 210 kDa. The
350-kDa chain was specifically recognized by another anti-5 chain
monoclonal antibody capable of recognizing denatured 5 chain on
immunoblots, whereas the 210-kDa chain was recognized by an anti-1
chain antibody. The purified 5 chain-containing laminin variants
(hereafter referred to as laminin-10/11) were highly active in
mediating adhesion of A549 cells to the substratum with potency as high
as that of laminin-5 and significantly higher than those of laminin-1,
laminin-2/4, or fibronectin. Adhesion to substrata coated with
laminin-10/11 was specifically inhibited by anti-integrin antibodies
directed against the integrin 3 or 1 subunit but not by those
against 2 or 6 subunit, indicating that laminin-10/11 is
specifically recognized by integrin 31. Given the wide
distribution of laminin-10/11 in the basement membrane of various
tissue types and dominant expression of integrin 31 in most
epithelial cells, specific interaction of laminin-10/11 with integrin
31 may play an important role in in vivo regulation of proliferation and differentiation of epithelial cells through the
basement membrane.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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