| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 27, 16635-16638, July 3, 1998
,,,
From the The SEC14 gene encodes a
phosphatidylinositol/phosphatidylcholine transfer protein essential for
secretion and growth in yeast (). Mutations (cki1,
cct1, and cpt1) in the CDP-choline pathway for
phosphatidylcholine synthesis suppress the sec14 growth
defect (), permitting sec14ts
cki1, sec14ts cct1, and
sec14ts cpt1 strains to grow at the
sec14ts restrictive temperature. Previously, we
reported that these double mutant strains also excrete the phospholipid
metabolites, choline and inositol (). We now report that these choline
and inositol excretion phenotypes are eliminated when the
SPO14 (PLD1) gene encoding phospholipase D1 is
deleted. In contrast to sec14ts
cki1 strains, sec14ts
cki1 pld1 strains are not viable at the
sec14ts restrictive temperature and exhibit a
pattern of invertase secretion comparable with
sec14ts strains. Thus, the PLD1
gene product appears to play an essential role in the suppression of
the sec14ts defect by CDP-choline pathway
mutations, indicating a role for phospholipase D1 in growth and
secretion. Furthermore, sec14ts strains exhibit
elevated Ca2+-independent, phophatidylinositol
4,5-bisphosphate-stimulated phospholipase D activity. We also propose
that phospholipase D1-mediated phosphatidylcholine turnover generates a
signal that activates transcription of INO1, the structural
gene for inositol 1-phosphate synthase.
Department of Biological Sciences, Carnegie
Mellon University, Pittsburgh, Pennsylvania 15213-2683 and the
§ Institute of Animal Biochemistry and Genetics, Slovak
Academy of Sciences, 90028 Ivanka pri Dunaji, Slovakia
This article has been cited by other articles:
|
|
 |
|
  G. M. Carman and S. A. Henry Phosphatidic Acid Plays a Central Role in the Transcriptional Regulation of Glycerophospholipid Synthesis in Saccharomyces cerevisiae J. Biol. Chem., December 28, 2007; 282(52): 37293 - 37297. [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Howe, G. D. Fairn, K. MacDonald, V. A. Bankaitis, and C. R. McMaster Regulation of Phosphoinositide Levels by the Phospholipid Transfer Protein Sec14p Controls Cdc42p/p21-Activated Kinase-Mediated Cell Cycle Progression at Cytokinesis Eukaryot. Cell, October 1, 2007; 6(10): 1814 - 1823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Tevzadze, J. V. Pierce, and R. E. Esposito Genetic Evidence for a SPO1-Dependent Signaling Pathway Controlling Meiotic Progression in Yeast Genetics, March 1, 2007; 175(3): 1213 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Gaspar, M. A. Aregullin, S. A. Jesch, and S. A. Henry Inositol Induces a Profound Alteration in the Pattern and Rate of Synthesis and Turnover of Membrane Lipids in Saccharomyces cerevisiae J. Biol. Chem., August 11, 2006; 281(32): 22773 - 22785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Boumann, J. Gubbens, M. C. Koorengevel, C.-S. Oh, C. E. Martin, A. J.R. Heck, J. Patton-Vogt, S. A. Henry, B. de Kruijff, and A. I.P.M. de Kroon Depletion of Phosphatidylcholine in Yeast Induces Shortening and Increased Saturation of the Lipid Acyl Chains: Evidence for Regulation of Intrinsic Membrane Curvature in a Eukaryote Mol. Biol. Cell, February 1, 2006; 17(2): 1006 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Jesch, X. Zhao, M. T. Wells, and S. A. Henry Genome-wide Analysis Reveals Inositol, Not Choline, as the Major Effector of Ino2p-Ino4p and Unfolded Protein Response Target Gene Expression in Yeast J. Biol. Chem., March 11, 2005; 280(10): 9106 - 9118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Fernandez Murray and C. R. McMaster Nte1p-mediated Deacylation of Phosphatidylcholine Functionally Interacts with Sec14p J. Biol. Chem., March 4, 2005; 280(9): 8544 - 8552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Chang, S. A. Jesch, M. L. Gaspar, and S. A. Henry Role of the Unfolded Protein Response Pathway in Secretory Stress and Regulation of INO1 Expression in Saccharomyces cerevisiae Genetics, December 1, 2004; 168(4): 1899 - 1913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. K. Peterman, Y. M. Ohol, L. J. McReynolds, and E. J. Luna Patellin1, a Novel Sec14-Like Protein, Localizes to the Cell Plate and Binds Phosphoinositides Plant Physiology, October 1, 2004; 136(2): 3080 - 3094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Zaccheo, D. Dinsdale, P. A. Meacock, and P. Glynn Neuropathy Target Esterase and Its Yeast Homologue Degrade Phosphatidylcholine to Glycerophosphocholine in Living Cells J. Biol. Chem., June 4, 2004; 279(23): 24024 - 24033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-S. Choi, A. Sreenivas, G.-S. Han, and G. M. Carman Regulation of Phospholipid Synthesis in the Yeast cki1{Delta} eki1{Delta} Mutant Defective in the Kennedy Pathway: THE CHO1-ENCODED PHOSPHATIDYLSERINE SYNTHASE IS REGULATED BY mRNA STABILITY J. Biol. Chem., March 26, 2004; 279(13): 12081 - 12087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Coluccio, M. Malzone, and A. M. Neiman Genetic Evidence of a Role for Membrane Lipid Composition in the Regulation of Soluble NEM-Sensitive Factor Receptor Function in Saccharomyces cerevisiae Genetics, January 1, 2004; 166(1): 89 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Rudge, V. A. Sciorra, M. Iwamoto, C. Zhou, T. Strahl, A. J. Morris, J. Thorner, and J. Engebrecht Roles of Phosphoinositides and of Spo14p (phospholipase D)-generated Phosphatidic Acid during Yeast Sporulation Mol. Biol. Cell, January 1, 2004; 15(1): 207 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. F. Outeiro and S. Lindquist Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology Science, December 5, 2003; 302(5651): 1772 - 1775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kagiwada and R. Zen Role of the Yeast VAP Homolog, Scs2p, in INO1 Expression and Phospholipid Metabolism J. Biochem., April 1, 2003; 133(4): 515 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Sciorra, S. A. Rudge, J. Wang, S. McLaughlin, J. Engebrecht, and A. J. Morris Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes J. Cell Biol., December 23, 2002; 159(6): 1039 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu, A. Sreenivas, D. B. Ostrander, and G. M. Carman Phosphorylation of Saccharomyces cerevisiae Choline Kinase on Ser30 and Ser85 by Protein Kinase A Regulates Phosphatidylcholine Synthesis by the CDP-choline Pathway J. Biol. Chem., September 13, 2002; 277(38): 34978 - 34986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Chang, E. W. Jones, and S. A. Henry Role of the Unfolded Protein Response Pathway in Regulation of INO1 and in the sec14 Bypass Mechanism in Saccharomyces cerevisiae Genetics, September 1, 2002; 162(1): 29 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Henneberry, M. M. Wright, and C. R. McMaster The Major Sites of Cellular Phospholipid Synthesis and Molecular Determinants of Fatty Acid and Lipid Head Group Specificity Mol. Biol. Cell, September 1, 2002; 13(9): 3148 - 3161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Yanagisawa, J. Marchena, Z. Xie, X. Li, P. P. Poon, R. A. Singer, G. C. Johnston, P. A. Randazzo, and V. A. Bankaitis Activity of Specific Lipid-regulated ADP Ribosylation Factor-GTPase-activating Proteins Is Required for Sec14p-dependent Golgi Secretory Function in Yeast Mol. Biol. Cell, July 1, 2002; 13(7): 2193 - 2206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Rudge, C. Zhou, and J. Engebrecht Differential Regulation of Saccharomyces cerevisiae Phospholipase D in Sporulation and Sec14-Independent Secretion Genetics, April 1, 2002; 160(4): 1353 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Rudge, T. R. Pettitt, C. Zhou, M. J. O. Wakelam, and J. Engebrecht SPO14 Separation-of-Function Mutations Define Unique Roles for Phospholipase D in Secretion and Cellular Differentiation in Saccharomyces cerevisiae Genetics, August 1, 2001; 158(4): 1431 - 1444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Hube, D. Hess, C. A. Baker, M. Schaller, W. Schäfer, and J. W. Dolan The role and relevance of phospholipase D1 during growth and dimorphism of Candida albicans Microbiology, April 1, 2001; 147(4): 879 - 889. [Abstract] [Full Text]
|
|
|
|
|
|
Z. Xie, M. Fang, and V. A. Bankaitis Evidence for an Intrinsic Toxicity of Phosphatidylcholine to Sec14p-dependent Protein Transport from the Yeast Golgi Complex Mol. Biol. Cell, April 1, 2001; 12(4): 1117 - 1129. [Abstract] [Full Text]
|
|
|
|
|
|
A. L. Henneberry, T. A. Lagace, N. D. Ridgway, and C. R. McMaster Phosphatidylcholine Synthesis Influences the Diacylglycerol Homeostasis Required for Sec14p-dependent Golgi Function and Cell Growth Mol. Biol. Cell, March 1, 2001; 12(3): 511 - 520. [Abstract] [Full Text]
|
|
|
|
|
|
X. Li, S. M. Routt, Z. Xie, X. Cui, M. Fang, M. A. Kearns, M. Bard, D. R. Kirsch, and V. A. Bankaitis Identification of a Novel Family of Nonclassic Yeast Phosphatidylinositol Transfer Proteins Whose Function Modulates Phospholipase D Activity and Sec14p-independent Cell Growth Mol. Biol. Cell, June 1, 2000; 11(6): 1989 - 2005. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Graves and S. A. Henry Regulation of the Yeast INO1 Gene: The Products of the INO2, INO4 and OPI1 Regulatory Genes Are Not Required for Repression in Response to Inositol Genetics, April 1, 2000; 154(4): 1485 - 1495. [Abstract] [Full Text]
|
|
|
|
|
|
H. Hama, E. A. Schnieders, J. Thorner, J. Y. Takemoto, and D. B. DeWald Direct Involvement of Phosphatidylinositol 4-Phosphate in Secretion in the Yeast Saccharomyces cerevisiae J. Biol. Chem., November 26, 1999; 274(48): 34294 - 34300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Rivas, B. G. Kearns, Z. Xie, S. Guo, M. C. Sekar, K. Hosaka, S. Kagiwada, J. D. York, and V. A. Bankaitis Pleiotropic Alterations in Lipid Metabolism in Yeast sac1 Mutants: Relationship to "Bypass Sec14p" and Inositol Auxotrophy Mol. Biol. Cell, July 1, 1999; 10(7): 2235 - 2250. [Abstract] [Full Text]
|
|
|
|
|
|
K. Kim, K.-H. Kim, M. K. Storey, D. R. Voelker, and G. M. Carman Isolation and Characterization of the Saccharomyces cerevisiae EKI1 Gene Encoding Ethanolamine Kinase J. Biol. Chem., May 21, 1999; 274(21): 14857 - 14866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Stock, H. Hama, D. B. DeWald, and J. Y. Takemoto SEC14-dependent Secretion in Saccharomyces cerevisiae. NONDEPENDENCE ON SPHINGOLIPID SYNTHESIS-COUPLED DIACYLGLYCEROL PRODUCTION J. Biol. Chem., May 7, 1999; 274(19): 12979 - 12983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ouyang, M. Ruiz-Noriega, and S. A. Henry The REG1 Gene Product Is Required for Repression of INO1 and Other Inositol-Sensitive Upstream Activating Sequence-Containing Genes of Yeast Genetics, May 1, 1999; 152(1): 89 - 100. [Abstract] [Full Text]
|
|
|
|
 |
|
 Z. Xie, M. Fang, M. P. Rivas, A. J. Faulkner, P. C. Sternweis, J. Engebrecht, and V. A. Bankaitis Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects PNAS, October 13, 1998; 95(21): 12346 - 12351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Ostrander, D. J. O'Brien, J. A. Gorman, and G. M. Carman Effect of CTP Synthetase Regulation by CTP on Phospholipid Synthesis in Saccharomyces cerevisiae J. Biol. Chem., July 24, 1998; 273(30): 18992 - 19001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Dowd, M. E. Bier, and J. L. Patton-Vogt Turnover of Phosphatidylcholine in Saccharomyces cerevisiae. THE ROLE OF THE CDP-CHOLINE PATHWAY J. Biol. Chem., February 2, 2001; 276(6): 3756 - 3763. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
