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J Biol Chem, Vol. 273, Issue 28, 17689-17695, July 10, 1998
From the Division of Nephrology, We report the cloning, sequence analysis, tissue
distribution, functional expression, and chromosomal localization of
the human pancreatic sodium bicarbonate cotransport protein (pancreatic NBC (pNBC)). The transporter was identified by searching the human expressed sequence tag data base. An I.M.A.G.E. clone W39298 was
identified, and a polymerase chain reaction probe was generated to
screen a human pancreas cDNA library. pNBC encodes a 1079-residue polypeptide that differs at the N terminus from the recently cloned human sodium bicarbonate cotransporter isolated from kidney (kNBC) (Burnham, C. E., Amlal, H., Wang, Z., Shull, G. E., and
Soleimani, M. (1997) J. Biol. Chem. 272, 19111-19114). Northern blot analysis using a probe specific for the N
terminus of pNBC revealed an ~7.7-kilobase transcript expressed
predominantly in pancreas, with less expression in kidney, brain,
liver, prostate, colon, stomach, thyroid, and spinal chord. In
contrast, a probe to the unique 5' region of kNBC detected an
~7.6-kilobase transcript only in the kidney. In situ
hybridization studies in pancreas revealed expression in the acini and
ductal cells. The gene was mapped to chromosome 4q21 using fluorescent
in situ hybridization. Expression of pNBC in Xenopus
laevis oocytes induced sodium bicarbonate cotransport. These data
demonstrate that pNBC encodes the sodium bicarbonate cotransporter in
the mammalian pancreas. pNBC is also expressed at a lower level in
several other organs, whereas kNBC is expressed uniquely in kidney.
Molecular Cloning, Chromosomal Localization, Tissue Distribution,
and Functional Expression of the Human Pancreatic Sodium Bicarbonate
Cotransporter
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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