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J Biol Chem, Vol. 273, Issue 29, 17995-17998, July 17, 1998
From the Phospholipid metabolism plays a central role in
regulating vesicular traffic in the secretory pathway. In mammalian
cells, activation of a Golgi-associated phospholipase D activity by
ADP-ribosylation factor results in hydrolysis of phosphatidylcholine to
phosphatidic acid (PA). This reaction has been proposed to stimulate
nascent secretory vesicle budding from the trans-Golgi network. It is unclear whether PA itself or diacylglycerol (DAG), a metabolite implicated in yeast secretory vesicle formation, regulates budding. To
distinguish between these possibilities we have used a permeabilized cell system supplemented with phospholipid-modifying enzymes that generate either DAG or PA. The data demonstrate that in mammalian cells
accumulation of PA rather than DAG is a key step in regulating budding
of secretory vesicles from the trans-Golgi network.
COMMUNICATION
Secretory Vesicle Budding from the Trans-Golgi Network Is
Mediated by Phosphatidic Acid Levels
and§
Department of Developmental and Molecular
Biology and § Anatomy and Structural Biology, Albert
Einstein College of Medicine, Bronx, New York 10461
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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