HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dron, M. Articles by Tovey, M. G. Search for Related Content PubMed PubMed Citation Articles by Dron, M. Articles by Tovey, M. G. Social Bookmarking                      What's this?

J Biol Chem, Vol. 273, Issue 29, 18015-18018, July 17, 1998

COMMUNICATION
Characterization of the Human Analogue of a Scrapie-responsive Gene

Michel Dron, Françoise Dandoy-Dron, Frédéric Guillo, Louisa Benboudjema, Jean-Jacques Hauw^¶, Pierre Lebon, Dominique Dormont^**, and Michael G. Tovey

From the  Laboratory of Viral Oncology CNRS UPR 9045, IFC1, 94801 Villejuif cedex, France, the ^¶ Laboratoire de Neuropathologie Raymond Escourolle, Groupe Hospitalier Pitié-Salpêtrière, INSERM U360, Association Claude Bernard, 75651 Paris cedex 13, France, the  Laboratoire de Virologie, Hôpital Saint Vincent de Paul, 75674 Paris cedex 14, France, and the ^** Laboratoire de Neurovirologie CEA, 92265 Fontenay aux Roses cedex, France

We have recently described a novel mRNA denominated ScRG-1, the level of which is increased in the brains of Scrapie-infected mice (Dandoy-Dron, F., Guillo, F., Benboudjema, L., Deslys, J.-P., Lasmézas, C., Dormont, D., Tovey, M. G., and Dron, M. (1998) J. Biol. Chem. 273, 7691-7697). The increase in ScRG-1 mRNA in the brain follows the accumulation of PrP^Sc, the proteinase K-resistant form of the prion protein (PrP), and precedes the widespread neuronal death that occurs in late stage disease. In the present study, we have isolated a cDNA encoding the human counterpart of ScRG-1. Comparison of the human and mouse transcripts firmly established that both sequences encode a highly conserved protein of 98 amino acids that contains a signal peptide, suggesting that the protein may be secreted. Examination of the distribution of human ScRG-1 mRNA in adult and fetal tissues revealed that the gene was expressed primarily in the central nervous system as a 0.7-kilobase message and was under strict developmental control.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati