| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 29, 18161-18164, July 17, 1998
From the We isolated the cDNA encoding a novel member
(207 amino acids) of the fibroblast growth factor (FGF) family from rat
embryos. Because this protein is the 18th documented member of the FGF family, we tentatively termed it FGF-18. We have also determined mouse
and human FGF-18 with high amino acid identity (99.5 and 99.0%) to rat
FGF-18, respectively. Among FGF family members, FGF-18 is most similar
(52.7% amino acid identity) to FGF-8 and FGF-17. FGF-18 has a typical
signal sequence at its amino terminus. Recombinant rat FGF-18, which
was efficiently secreted by High Five insect cells infected with
recombinant baculovirus containing the cDNA, induced neurite
outgrowth in PC12 cells. The expression of FGF-18 mRNA
was examined in adult rat tissues and embryos by Northern blotting
analysis and in situ hybridization. FGF-18
mRNA of ~2.7 kilobases was preferentially detected in the lung
among adult rat tissues examined. In rat embryos, FGF-18
mRNA was detected in several discrete regions at embryonic days
14.5 and 19.5 but not at E10.5. The temporal and spatial patterns of
FGF-18 mRNA expression in embryos are quite different
from those of FGF-8 and FGF-17 mRNAs
reported. The present results indicate that FGF-18 is a unique secreted
signaling molecule in the adult lung and developing tissues.
Structure and Expression of the mRNA Encoding a Novel
Fibroblast Growth Factor, FGF-18
,,,,
Department of Genetic Biochemistry, Kyoto
University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto
606-8501, Japan and the § Department of Biotechnology,
Faculty of Engineering, Kyoto Sangyo University, Kita,
Kyoto 603-8555, Japan
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Zhang, O. A. Ibrahimi, S. K. Olsen, H. Umemori, M. Mohammadi, and D. M. Ornitz Receptor Specificity of the Fibroblast Growth Factor Family: THE COMPLETE MAMMALIAN FGF FAMILY J. Biol. Chem., June 9, 2006; 281(23): 15694 - 15700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ishibe, T. Nakayama, T. Okamoto, T. Aoyama, K. Nishijo, K. R. Shibata, Y. Shima, S. Nagayama, T. Katagiri, Y. Nakamura, et al. Disruption of Fibroblast Growth Factor Signal Pathway Inhibits the Growth of Synovial Sarcomas: Potential Application of Signal Inhibitors to Molecular Target Therapy Clin. Cancer Res., April 1, 2005; 11(7): 2702 - 2712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Chailley-Heu, O. Boucherat, A.-M. Barlier-Mur, and J. R. Bourbon FGF-18 is upregulated in the postnatal rat lung and enhances elastogenesis in myofibroblasts Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L43 - L51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Hyatt, X. Shangguan, and J. M. Shannon FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1116 - L1126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Reinhold, M. Abe, R. M. Kapadia, Z. Liao, and M. C. Naski FGF18 Represses Noggin Expression and Is Induced by Calcineurin J. Biol. Chem., September 10, 2004; 279(37): 38209 - 38219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nakazawa, M. Yashiro, and K. Hirakawa Keratinocyte Growth Factor Produced by Gastric Fibroblasts Specifically Stimulates Proliferation of Cancer Cells from Scirrhous Gastric Carcinoma Cancer Res., December 15, 2003; 63(24): 8848 - 8852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimokawa, Y. Furukawa, M. Sakai, M. Li, N. Miwa, Y.-M. Lin, and Y. Nakamura Involvement of the FGF18 Gene in Colorectal Carcinogenesis, as a Novel Downstream Target of the {beta}-Catenin/T-Cell Factor Complex Cancer Res., October 1, 2003; 63(19): 6116 - 6120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. W. Draper, D. W. Stock, and C. B. Kimmel Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development Development, October 1, 2003; 130(19): 4639 - 4654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Ellsworth, R. Garcia, J. Yu, and M. S. Kindy Fibroblast Growth Factor-18 Reduced Infarct Volumes and Behavioral Deficits After Transient Occlusion of the Middle Cerebral Artery in Rats Stroke, June 1, 2003; 34(6): 1507 - 1512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cavallaro, V. D'Agata, P. Manickam, F. Dufour, and D. L. Alkon Memory-specific temporal profiles of gene expression in the hippocampus PNAS, December 10, 2002; 99(25): 16279 - 16284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Deepa, Y. Umehara, S. Higashiyama, N. Itoh, and K. Sugahara Specific Molecular Interactions of Oversulfated Chondroitin Sulfate E with Various Heparin-binding Growth Factors. IMPLICATIONS AS A PHYSIOLOGICAL BINDING PARTNER IN THE BRAIN AND OTHER TISSUES J. Biol. Chem., November 8, 2002; 277(46): 43707 - 43716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Whitsett, J. C. Clark, L. Picard, J. W. Tichelaar, S. E. Wert, N. Itoh, A.-K. T. Perl, and M. T. Stahlman Fibroblast Growth Factor 18 Influences Proximal Programming during Lung Morphogenesis J. Biol. Chem., June 14, 2002; 277(25): 22743 - 22749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ohbayashi, M. Shibayama, Y. Kurotaki, M. Imanishi, T. Fujimori, N. Itoh, and S. Takada FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis Genes & Dev., April 1, 2002; 16(7): 870 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimoaka, T. Ogasawara, A. Yonamine, D. Chikazu, H. Kawano, K. Nakamura, N. Itoh, and H. Kawaguchi Regulation of Osteoblast, Chondrocyte, and Osteoclast Functions by Fibroblast Growth Factor (FGF)-18 in Comparison with FGF-2 and FGF-10 J. Biol. Chem., February 22, 2002; 277(9): 7493 - 7500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kinkl, J. Sahel, and D. Hicks Alternate FGF2-ERK1/2 Signaling Pathways in Retinal Photoreceptor and Glial Cells in Vitro J. Biol. Chem., November 16, 2001; 276(47): 43871 - 43878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Whitsett, S. W. Glasser, J. W. Tichelaar, A.-K. T. Perl, J. C. Clark, and S. E. Wert Transgenic Models for Study of Lung Morphogenesis and Repair : Parker B. Francis Lecture Chest, July 1, 2001; 120(2007): 27S - 30S. [Full Text] [PDF]
|
|
|
|
|
|
J. C. Clark, J. W. Tichelaar, S. E. Wert, N. Itoh, A.-K. T. Perl, M. T. Stahlman, and J. A. Whitsett FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo Am J Physiol Lung Cell Mol Physiol, April 1, 2001; 280(4): L705 - L715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Auguste, D. B. Gürsel, S. Lemière, D. Reimers, P. Cuevas, F. Carceller, J. P. Di Santo, and A. Bikfalvi Inhibition of Fibroblast Growth Factor/Fibroblast Growth Factor Receptor Activity in Glioma Cells Impedes Tumor Growth by Both Angiogenesis-dependent and -independent Mechanisms Cancer Res., February 1, 2001; 61(4): 1717 - 1726. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Wagle and J. P. Singh Fibroblast Growth Factor Protects Nitric Oxide-Induced Apoptosis in Neuronal SHSY-5Y Cells J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 889 - 895. [Abstract] [Full Text]
|
|
|
|
|
|
H.-D. Beer, L. Vindevoghel, M. J. Gait, J.-M. Revest, D. R. Duan, I. Mason, C. Dickson, and S. Werner Fibroblast Growth Factor (FGF) Receptor 1-IIIb Is a Naturally Occurring Functional Receptor for FGFs That Is Preferentially Expressed in the Skin and the Brain J. Biol. Chem., May 19, 2000; 275(21): 16091 - 16097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Konishi, T. Mikami, M. Yamasaki, A. Miyake, and N. Itoh Fibroblast Growth Factor-16 Is a Growth Factor for Embryonic Brown Adipocytes J. Biol. Chem., April 14, 2000; 275(16): 12119 - 12122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kumar, P. C. McDonnell, R. Lehr, L. Tierney, M. N. Tzimas, D. E. Griswold, E. A. Capper, R. Tal-Singer, G. I. Wells, M. L. Doyle, et al. Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family J. Biol. Chem., March 31, 2000; 275(14): 10308 - 10314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. BAILLY, F. SOULET, D. LEROY, F. AMALRIC, and G. BOUCHE Uncoupling of cell proliferation and differentiation activities of basic fibroblast growth factor FASEB J, February 1, 2000; 14(2): 333 - 344. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. V. Cronauer, S. Stadlmann, H. Klocker, B. Abendstein, I. E. Eder, H. Rogatsch, A. G. Zeimet, C. Marth, and F. A. Offner Basic Fibroblast Growth Factor Synthesis by Human Peritoneal Mesothelial Cells : Induction by Interleukin-1 Am. J. Pathol., December 1, 1999; 155(6): 1977 - 1984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Touriol, A. Morillon, M.-C. Gensac, H. Prats, and A.-C. Prats Expression of Human Fibroblast Growth Factor 2 mRNA Is Post-transcriptionally Controlled by a Unique Destabilizing Element Present in the 3'-Untranslated Region between Alternative Polyadenylation Sites J. Biol. Chem., July 23, 1999; 274(30): 21402 - 21408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Sun, E. N. Meyers, M. Lewandoski, and G. R. Martin Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo Genes & Dev., July 15, 1999; 13(14): 1834 - 1846. [Abstract] [Full Text]
|
|
|
|
|
|
F. Miralles, P. Czernichow, K. Ozaki, N. Itoh, and R. Scharfmann Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas PNAS, May 25, 1999; 96(11): 6267 - 6272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Pye and J. T. Gallagher Monomer Complexes of Basic Fibroblast Growth Factor and Heparan Sulfate Oligosaccharides Are the Minimal Functional Unit for Cell Activation J. Biol. Chem., May 7, 1999; 274(19): 13456 - 13461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Minowada, L. Jarvis, C. Chi, A Neubuser, X Sun, N Hacohen, M. Krasnow, and G. Martin Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed Development, January 10, 1999; 126(20): 4465 - 4475. [Abstract] [PDF]
|
|
|
|
|
|
S. H. Lee, D. J. Schloss, and J. L. Swain Maintenance of Vascular Integrity in the Embryo Requires Signaling through the Fibroblast Growth Factor Receptor J. Biol. Chem., October 20, 2000; 275(43): 33679 - 33687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Russo, R. Ragone, A. M. Facchiano, M. C. Capogrossi, and A. Facchiano Platelet-derived Growth Factor-BB and Basic Fibroblast Growth Factor Directly Interact in Vitro with High Affinity J. Biol. Chem., January 4, 2002; 277(2): 1284 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Touriol, M. Roussigne, M.-C. Gensac, H. Prats, and A.-C. Prats Alternative Translation Initiation of Human Fibroblast Growth Factor 2 mRNA Controlled by Its 3'-Untranslated Region Involves a Poly(A) Switch and a Translational Enhancer J. Biol. Chem., June 16, 2000; 275(25): 19361 - 19367. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
