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J Biol Chem, Vol. 273, Issue 29, 18300-18307, July 17, 1998
From the The chicken lysozyme gene domain is distinguished
by a broad knowledge of how its expression is regulated. Here, we
examined the in vivo replication of the lysozyme gene locus
using polymerase chain reaction amplification and competitive
polymerase chain reaction of size-fractionated, nascent DNA strands. We
found that DNA replication initiates at multiple sites within a broad
initiation zone spanning at least 20 kilobases, which includes most of
the lysozyme gene domain. The 5' border of this zone is probably
located downstream of the lysozyme 5' nuclear matrix attachment region. Preferred initiation occurs in a 3'-located subzone. The initiation zone at the lysozyme gene locus is also active in nonexpressing liver
DU249 cells. Furthermore, examining the timing of DNA replication at
the lysozyme gene locus revealed that the gene locus replicates early
during S phase in both HD11 and DU249 cells, irrespective of its
transcriptional activity.
An Initiation Zone of Chromosomal DNA Replication at the Chicken
Lysozyme Gene Locus
,,, and Institut für Tierzucht und
Tierverhalten, Bundesforschungsanstalt für Landwirtschaft,
Dörnbergstrasse 25-27, 29223 Celle, Germany and ¶ Institut
für Physiologische Chemie, Universität Hamburg,
Martinistrasse 52, 20246 Hamburg, Germany
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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