Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cens, T.
Right arrow Articles by Charnet, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cens, T.
Right arrow Articles by Charnet, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J Biol Chem, Vol. 273, Issue 29, 18308-18315, July 17, 1998

Promotion and Inhibition of L-type Ca2+ Channel Facilitation by Distinct Domains of the beta  Subunit

Thierry Cens, Sophie Restituito, Alice Vallentin, and Pierre Charnet

From the Centre de Recherche de Biochimie Macromoléculaire, CNRS Unité Propre de Recherche 1086, 1919 Route de Mende, BP 5051, F34033 Montpellier, France

Ca2+ current potentiation by conditioning depolarization is a general mechanism by which excitable cells can control the level of Ca2+ entry during repetitive depolarizations. Several types of Ca2+ channels are sensitive to conditioning depolarization, however, using clearly distinguishable mechanisms. In the case of L-type Ca2+ channels, prepulse-induced current facilitation can only be recorded when the pore-forming alpha 1C subunit is coexpressed with the auxiliary beta 1, beta 3, or beta 4, but not beta 2, subunit. These four beta  subunits are composed of two conserved domains surrounded by central, N-terminal, and C-terminal variable regions. Using different deleted and chimeric forms of the beta 1 and beta 2 subunits, we have mapped essential sequences for L-type Ca2+ channel facilitation. A first sequence, located in the second conserved domain of all beta  subunits, is responsible for the promotion of current facilitation by the beta  subunit. A second sequence of 16 amino acids, located on the N-terminal tail of the beta 2 subunit, induces a transferable block of L-type current facilitation. Site-specific mutations reveal the essential inhibitory role played by three positive charges on this segment. The lack of prepulse-induced current facilitation recorded with some truncated forms of the beta 2 subunit suggests the existence of an additional inhibitory sequence in the beta 2 subunit.

Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 FASEB J.Home page
Y. Lu, Y. Lv, Y. Ye, Y. Wang, Y. Hong, M. E. Fortini, Y. Zhong, and Z. Xie
A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila
FASEB J, August 1, 2007; 21(10): 2368 - 2378.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
H. E. D. J. ter Keurs and P. A. Boyden
Calcium and Arrhythmogenesis
Physiol Rev, April 1, 2007; 87(2): 457 - 506.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. Calin-Jageman, K. Yu, R. A. Hall, L. Mei, and A. Lee
Erbin Enhances Voltage-Dependent Facilitation of Cav1.3 Ca2+ Channels through Relief of an Autoinhibitory Domain in the Cav1.3 {alpha}1 Subunit
J. Neurosci., February 7, 2007; 27(6): 1374 - 1385.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T.-S. Lee, R. Karl, S. Moosmang, P. Lenhardt, N. Klugbauer, F. Hofmann, T. Kleppisch, and A. Welling
Calmodulin Kinase II Is Involved in Voltage-dependent Facilitation of the L-type Cav1.2 Calcium Channel: IDENTIFICATION OF THE PHOSPHORYLATION SITES
J. Biol. Chem., September 1, 2006; 281(35): 25560 - 25567.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Berrou, Y. Dodier, A. Raybaud, A. Tousignant, O. Dafi, J. N. Pelletier, and L. Parent
The C-terminal Residues in the Alpha-interacting Domain (AID) Helix Anchor CaV{beta} Subunit Interaction and Modulation of CaV2.3 Channels
J. Biol. Chem., January 7, 2005; 280(1): 494 - 505.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. D. Foell, R. C. Balijepalli, B. P. Delisle, A. M. R. Yunker, S. L. Robia, J. W. Walker, M. W. McEnery, C. T. January, and T. J. Kamp
Molecular heterogeneity of calcium channel {beta}-subunits in canine and human heart: evidence for differential subcellular localization
Physiol Genomics, April 13, 2004; 17(2): 183 - 200.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Alvarez, J. Hamplova, A. Hohaus, I. Morano, H. Haase, and G. Vassort
Calcium Current in Rat Cardiomyocytes Is Modulated by the Carboxyl-terminal Ahnak Domain
J. Biol. Chem., March 26, 2004; 279(13): 12456 - 12461.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Schjott, S.-C. Hsu, and M. R. Plummer
The Neuronal {beta}4 Subunit Increases the Unitary Conductance of L-type Voltage-gated Calcium Channels in PC12 Cells
J. Biol. Chem., September 5, 2003; 278(36): 33936 - 33942.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
V. Leuranguer, R. T. Dirksen, and K. G. Beam
Potentiated L-type Ca2+ Channels Rectify
J. Gen. Physiol., May 27, 2003; 121(6): 541 - 550.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. E. Hall, J. Liu, A. A. F. Sima, and J. W. Wiley
Impaired Inhibitory G-Protein Function Contributes to Increased Calcium Currents in Rats With Diabetic Neuropathy
J Neurophysiol, August 1, 2001; 86(2): 760 - 770.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Restituito, T. Cens, C. Barrere, S. Geib, S. Galas, M. De Waard, and P. Charnet
The {beta}2a Subunit Is a Molecular Groom for the Ca2+ Channel Inactivation Gate
J. Neurosci., December 15, 2000; 20(24): 9046 - 9052.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C Canti, Y Bogdanov, and A C Dolphin
Interaction between G proteins and accessory {beta} subunits in the regulation of {alpha}1B calcium channels in Xenopus oocytes
J. Physiol., September 15, 2000; 527(3): 419 - 432.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. J. Kamp, H. Hu, and E. Marban
Voltage-dependent facilitation of cardiac L-type Ca channels expressed in HEK-293 cells requires beta -subunit
Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H126 - H136.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
U. Gerster, B. Neuhuber, K. Groschner, J. Striessnig, and B. E Flucher
Current modulation and membrane targeting of the calcium channel {alpha}1C subunit are independent functions of the {beta} subunit
J. Physiol., June 1, 1999; 517(2): 353 - 368.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1998 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement