Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chaudhry, A. Z.
Right arrow Articles by Gronostajski, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chaudhry, A. Z.
Right arrow Articles by Gronostajski, R. M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J Biol Chem, Vol. 273, Issue 29, 18538-18546, July 17, 1998

Nuclear Factor I (NFI) Isoforms Differentially Activate Simple versus Complex NFI-responsive Promoters

Ali Z. ChaudhryDagger , Alfredo D. Vitullo§, and Richard M. GronostajskiDagger §

From the Dagger  Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106 and the § Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195

Promoter-specific differences in the function of transcription factors play a central role in the regulation of gene expression. We have measured the maximal transcriptional activation potentials of nuclear factor I (NFI) proteins encoded by each of the four identified NFI genes (NFI-A, -B, -C, and -X) by transient transfection in JEG-3 cells using two model NFI-dependent promoters: 1) a simple chimeric promoter containing a single NFI-binding site upstream of the adenovirus major late promoter (NFI-Ad), and 2) the more complex mouse mammary tumor virus long terminal repeat promoter. The relative activation potentials for the NFI isoforms differed between the two promoters, with NFI-X being the strongest activator of NFI-Ad and NFI-B being the strongest activator of the MMTV promoter. To determine if these promoter-specific differences in activation potential were due to the presence of glucocorticoid response elements (GREs), we added GREs upstream of the NFI-binding site in NFI-Ad. NFI-X remains the strongest activator of the GRE containing simple promoter, indicating that differences in relative activation potential are not due solely to the presence of GREs. Since NFI proteins bind to DNA as dimers, we assessed the activation potentials of NFI heterodimers. Here, we show that NFI heterodimers have intermediate activation potentials compared with homodimers, demonstrating one potential mechanism by which different NFI proteins can regulate gene expression.

Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 FASEB J.Home page
R. Alikhani-Koupaei, F. Fouladkou, P. Fustier, B. Cenni, A. M. Sharma, H.-C. Deter, B. M. Frey, and F. J. Frey
Identification of polymorphisms in the human 11beta-hydroxysteroid dehydrogenase type 2 gene promoter: functional characterization and relevance for salt sensitivity
FASEB J, November 1, 2007; 21(13): 3618 - 3628.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
M. Shimizu, Mst. H. Akter, Y. Emi, R. Sato, T. Yamaguchi, F. Hirose, and T. Osumi
Peroxisome Proliferator-Activated Receptor Subtypes Differentially Cooperate with Other Transcription Factors in Selective Transactivation of the Perilipin/PEX11{alpha} Gene Pair.
J. Biochem., March 1, 2006; 139(3): 563 - 573.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. M. Johansson, M. Kannius-Janson, A. Gritli-Linde, G. Bjursell, and J. Nilsson
Nuclear Factor 1-C2 Is Regulated by Prolactin and Shows a Distinct Expression Pattern in the Mouse Mammary Epithelial Cells during Development
Mol. Endocrinol., April 1, 2005; 19(4): 992 - 1003.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
G. Steele-Perkins, C. Plachez, K. G. Butz, G. Yang, C. J. Bachurski, S. L. Kinsman, E. D. Litwack, L. J. Richards, and R. M. Gronostajski
The Transcription Factor Gene Nfib Is Essential for both Lung Maturation and Brain Development
Mol. Cell. Biol., January 15, 2005; 25(2): 685 - 698.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Belikov, C. Astrand, P.-H. Holmqvist, and O. Wrange
Chromatin-Mediated Restriction of Nuclear Factor 1/CTF Binding in a Repressed and Hormone-Activated Promoter In Vivo
Mol. Cell. Biol., April 1, 2004; 24(7): 3036 - 3047.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. J. Bachurski, G. H. Yang, T. A. Currier, R. M. Gronostajski, and D. Hong
Nuclear Factor I/Thyroid Transcription Factor 1 Interactions Modulate Surfactant Protein C Transcription
Mol. Cell. Biol., December 15, 2003; 23(24): 9014 - 9024.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Tone, Y. Tone, E. Adams, S. F. Yates, M. R. Frewin, S. P. Cobbold, and H. Waldmann
From The Cover: Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells
PNAS, December 9, 2003; 100(25): 15059 - 15064.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Shu, K. G. Butz, C. Plachez, R. M. Gronostajski, and L. J. Richards
Abnormal Development of Forebrain Midline Glia and Commissural Projections in Nfia Knock-Out Mice
J. Neurosci., January 1, 2003; 23(1): 203 - 212.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Kannius-Janson, E. M. Johansson, G. Bjursell, and J. Nilsson
Nuclear Factor 1-C2 Contributes to the Tissue-specific Activation of a Milk Protein Gene in the Differentiating Mammary Gland
J. Biol. Chem., May 10, 2002; 277(20): 17589 - 17596.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. S. Mukhopadhyay, S. L. Wyszomierski, R. M. Gronostajski, and J. M. Rosen
Differential Interactions of Specific Nuclear Factor I Isoforms with the Glucocorticoid Receptor and STAT5 in the Cooperative Regulation of WAP Gene Transcription
Mol. Cell. Biol., October 15, 2001; 21(20): 6859 - 6869.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. J. Lin, J. W. M. Martens, and W. L. Miller
NF-1C, Sp1, and Sp3 Are Essential for Transcription of the Human Gene for P450c17 (Steroid 17{alpha}-hydroxylase/17,20 lyase) in Human Adrenal NCI-H295A Cells
Mol. Endocrinol., August 1, 2001; 15(8): 1277 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Y. Morel, X. Coumoul, A. Nalpas, and R. Barouki
Nuclear Factor I/CCAAT Box Transcription Factor trans-Activating Domain Is a Negative Sensor of Cellular Stress
Mol. Pharmacol., April 13, 2001; 58(6): 1239 - 1246.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
S. Ethelberg, B. D. Tzschaschel, A. Luz, S. J. Diaz-Cano, F. S. Pedersen, and J. Schmidt
Increased Induction of Osteopetrosis, but Unaltered Lymphomagenicity, by Murine Leukemia Virus SL3-3 after Mutation of a Nuclear Factor 1 Site in the Enhancer
J. Virol., December 1, 1999; 73(12): 10406 - 10415.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. das Neves, C. S. Duchala, F. Godinho, M. A. Haxhiu, C. Colmenares, W. B. Macklin, C. E. Campbell, K. G. Butz, and R. M. Gronostajski
Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum
PNAS, October 12, 1999; 96(21): 11946 - 11951.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Leahy, D. R. Crawford, G. Grossman, R. M. Gronostajski, and R. W. Hanson
CREB Binding Protein Coordinates the Function of Multiple Transcription Factors Including Nuclear Factor I to Regulate Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription
J. Biol. Chem., March 26, 1999; 274(13): 8813 - 8822.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Z. Chaudhry, A. D. Vitullo, and R. M. Gronostajski
Nuclear Factor I-mediated Repression of the Mouse Mammary Tumor Virus Promoter Is Abrogated by the Coactivators p300/CBP and SRC-1
J. Biol. Chem., March 12, 1999; 274(11): 7072 - 7081.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Massaad, M. Paradon, C. Jacques, C. Salvat, G. Bereziat, F. Berenbaum, and J.-L. Olivier
Induction of Secreted Type IIA Phospholipase A2 Gene Transcription by Interleukin-1beta . ROLE OF C/EBP FACTORS
J. Biol. Chem., July 21, 2000; 275(30): 22686 - 22694.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. A. Bisgrove, E. A. Monckton, M. Packer, and R. Godbout
Regulation of Brain Fatty Acid-binding Protein Expression by Differential Phosphorylation of Nuclear Factor I in Malignant Glioma Cell Lines
J. Biol. Chem., September 22, 2000; 275(39): 30668 - 30676.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1998 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement