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J Biol Chem, Vol. 273, Issue 29, 18633-18639, July 17, 1998

Molecular Cloning and Characterization of the Mouse tag7 Gene Encoding a Novel Cytokine

Sergei L. Kiselev, Olga S. Kustikova, Elena V. Korobko, Egor B. Prokhortchouk, Andrei A. Kabishev, Evgenii M. Lukanidin, and Georgii P. Georgiev

From the  Institute of Gene Biology, 34/5 Vavilova St., Moscow 117334, Russia and the  Danish Cancer Society, Strandboulevarden 49, 7.1, DK-2100 Copenhagen, Denmark

Cloning of the mouse tag7 gene encoding a novel cytokine is described. The Tag7 protein consists of 182 amino acids. Genomic organization of the tag7 gene and its promoter region remind those of the genes of the tumor necrosis factor locus, although the tag7 gene is not linked to this locus. The gene is located on chromosome 7 at the area that corresponds to band 7A3, which has genetic linkage with lupus-like disease in mouse models. tag7 transcription is essential for lymphoid organs. It is also detected in certain areas of lungs, brain, and intestine and in some tumors. Tag7 protein is detectable in both cell-associated and soluble forms. The soluble form of Tag7 triggers apoptosis in mouse L929 cells in vitro and does not involve NF-B activation. The relationship between Tag7 and tumor necrosis factor family of ligands is discussed.

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