|
Vol. 273, Issue 3, 1832-1837, January 16, 1998
p38 Kinase Activity Is Essential for Osmotic Induction of
mRNAs for HSP70 and Transporter for Organic Solute Betaine in
Madin-Darby Canine Kidney Cells
David
Sheikh-Hamad ,
John
Di Mari¶,
Wadi N.
Suki ,
Robert
Safirstein¶,
Bruns A.
Watts III¶, and
Diane
Rouse
From the Renal Division, Department of Medicine,
Baylor College of Medicine, Houston, Texas 77030 and the
¶ Renal Division, Department of Medicine, University of Texas
Medical Branch, Galveston, Texas 77555
In renal cells, hypertonicity induces genes for
heat shock proteins (HSP70, B-crystallin), as well as enzymes and
transporters directly involved in the metabolism and transport of
protective organic osmolytes. While heat shock proteins are induced by
many stresses including osmotic stress, the induction of the osmolytes genes appears to be specific to osmotic stress. These two adaptive mechanisms allow kidney cells to survive and function in the hypertonic environment that exists on routine basis in kidney medulla. In mammalian cells, hypertonicity induces three mitogen-activated protein
kinase pathways: ERK (extracellular regulated kinase), JNK (Jun
N-terminal kinase), and p38. ERK activation by osmotic stress is a
consistent finding in many cells, but it is not essential for
transcriptional regulation of mRNA for transporter of organic osmolyte betaine. While the growth of yeast cells on NaCl-supplemented medium is dependent on HOG1 pathway, it is still unclear which pathway
mediates the adaptation to osmotic stress in mammalian cells. Here, we
show that inhibition of p38 kinase activity, using the specific
inhibitor SB203580
(4-(fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl) imidazole),
abolishes the hypertonicity-mediated induction of mRNAs for HSP70
and betaine transporter in Madin-Darby canine kidney cells. The
inhibition is dose-dependent and correlates with the
in situ activity of native p38 kinase, determined as MAPKAPK-2 activity in cell extracts. As reported previously, the activities of ERK-1 and -2 were not affected by SB203580, but surprisingly, inhibition of native p38 kinase activity correlates with
up-regulation of native JNK-1 activity in osmotically stressed cells.
p38 mRNA is induced by hypertonic stress and is attenuated with p38
kinase inhibition. We also find that thermal induction of HSP70
mRNA is not affected by p38 kinase inhibition. Such findings suggest that p38 kinase activity is essential for the induction of
genes involved in the adaptation of mammalian cells to osmotic stress
and that the increased activity of JNK-1 during p38 kinase inhibition
is consistent with regulation of JNK-1 by p38 kinase in osmotically
stressed cells. In addition, the transduction pathways mediating HSP70
mRNA induction by different stresses appear to be divergent;
osmotic induction of HSP70 is p38 kinase-dependent, while
thermal induction is not.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.

CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati What's this?
This article has been cited by other articles:

|
 |

|
 |
 
C. Kuper, D. Steinert, M.-L. Fraek, F.-X. Beck, and W. Neuhofer
EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions
Am J Physiol Renal Physiol,
May 1, 2009;
296(5):
F1100 - F1108.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Kino, H. Takatori, I. Manoli, Y. Wang, A. Tiulpakov, M. R. Blackman, Y. A. Su, G. P. Chrousos, A. H. DeCherney, and J. H. Segars
Brx Mediates the Response of Lymphocytes to Osmotic Stress Through the Activation of NFAT5
Sci. Signal.,
February 10, 2009;
2(57):
ra5 - ra5.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Anestis, H. O. Portner, A. Lazou, and B. Michaelidis
Metabolic and molecular stress responses of sublittoral bearded horse mussel Modiolus barbatus to warming sea water: implications for vertical zonation
J. Exp. Biol.,
September 1, 2008;
211(17):
2889 - 2898.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Bissonnette, K. Lahjouji, M. J. Coady, and J.-Y. Lapointe
Effects of hyperosmolarity on the Na+-myo-inositol cotransporter SMIT2 stably transfected in the Madin-Darby canine kidney cell line
Am J Physiol Cell Physiol,
September 1, 2008;
295(3):
C791 - C799.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. B. Burg, J. D. Ferraris, and N. I. Dmitrieva
Cellular Response to Hyperosmotic Stresses
Physiol Rev,
October 1, 2007;
87(4):
1441 - 1474.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Anestis, A. Lazou, H. O. Portner, and B. Michaelidis
Behavioral, metabolic, and molecular stress responses of marine bivalve Mytilus galloprovincialis during long-term acclimation at increasing ambient temperature
Am J Physiol Regulatory Integrative Comp Physiol,
August 1, 2007;
293(2):
R911 - R921.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Chen, M. P. Schnetz, C. E. Irarrazabal, R.-F. Shen, C. K. Williams, M. B. Burg, and J. D. Ferraris
Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1
Am J Physiol Renal Physiol,
March 1, 2007;
292(3):
F981 - F992.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Rafiee, M. E. Theriot, V. M. Nelson, J. Heidemann, Y. Kanaa, S. A. Horowitz, A. Rogaczewski, C. P. Johnson, I. Ali, R. Shaker, et al.
Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27
Am J Physiol Cell Physiol,
November 1, 2006;
291(5):
C931 - C945.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Padda, A. Wamsley-Davis, M. C. Gustin, R. Ross, C. Yu, and D. Sheikh-Hamad
MEKK3-mediated signaling to p38 kinase and TonE in hypertonically stressed kidney cells
Am J Physiol Renal Physiol,
October 1, 2006;
291(4):
F874 - F881.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Medicherla, A. A. Protter, J. Y. Ma, R. Mangadu, R. Almirez, B. Koppelman, I. Kerr, T. A. Navas, F. Movius, M. Reddy, et al.
Preventive and Therapeutic Potential of p38{alpha}-Selective Mitogen-Activated Protein Kinase Inhibitor in Nonobese Diabetic Mice with Type 1 Diabetes
J. Pharmacol. Exp. Ther.,
July 1, 2006;
318(1):
99 - 107.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Liu, R. Aneja, C. Liu, L. Sun, J. Gao, H. Wang, J.-T. Dong, V. Sarli, A. Giannis, H. C. Joshi, et al.
Inhibition of the Mitotic Kinesin Eg5 Up-regulates Hsp70 through the Phosphatidylinositol 3-Kinase/Akt Pathway in Multiple Myeloma Cells
J. Biol. Chem.,
June 30, 2006;
281(26):
18090 - 18097.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. E. Irarrazabal, M. B. Burg, S. G. Ward, and J. D. Ferraris
Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation
PNAS,
June 6, 2006;
103(23):
8882 - 8887.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Xu, R. T. Worrell, H. C. Li, S. L. Barone, S. Petrovic, H. Amlal, and M. Soleimani
Chloride/Bicarbonate Exchanger SLC26A7 Is Localized in Endosomes in Medullary Collecting Duct Cells and Is Targeted to the Basolateral Membrane in Hypertonicity and Potassium Depletion
J. Am. Soc. Nephrol.,
April 1, 2006;
17(4):
956 - 967.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. W. Moeckel, L. Zhang, X. Chen, M. Rossini, R. Zent, and A. Pozzi
Role of integrin {alpha}1{beta}1 in the regulation of renal medullary osmolyte concentration
Am J Physiol Renal Physiol,
January 1, 2006;
290(1):
F223 - F231.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Yang, A. Zhang, M. Honeggar, D. E. Kohan, D. Mizel, K. Sanders, J. R. Hoidal, J. P. Briggs, and J. B. Schnermann
Hypertonic Induction of COX-2 in Collecting Duct Cells by Reactive Oxygen Species of Mitochondrial Origin
J. Biol. Chem.,
October 14, 2005;
280(41):
34966 - 34973.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Kultz
DNA damage signals facilitate osmotic stress adaptation
Am J Physiol Renal Physiol,
September 1, 2005;
289(3):
F504 - F505.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Z. Zhang, J. D. Ferraris, C. E. Irarrazabal, N. I. Dmitrieva, J.-H. Park, and M. B. Burg
Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP
Am J Physiol Renal Physiol,
September 1, 2005;
289(3):
F506 - F511.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. P. Kim, X. Wang, J. Zhang, G. Y. Suh, I. J. Benjamin, S. W. Ryter, and A. M. K. Choi
Heat Shock Protein-70 Mediates the Cytoprotective Effect of Carbon Monoxide: Involvement of p38{beta} MAPK and Heat Shock Factor-1
J. Immunol.,
August 15, 2005;
175(4):
2622 - 2629.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. I. Dmitrieva, M. B. Burg, and J. D. Ferraris
DNA damage and osmotic regulation in the kidney
Am J Physiol Renal Physiol,
July 1, 2005;
289(1):
F2 - F7.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. S. Marshall, C. G. Ossum, and E. K. Hoffmann
Hypotonic shock mediation by p38 MAPK, JNK, PKC, FAK, OSR1 and SPAK in osmosensing chloride secreting cells of killifish opercular epithelium
J. Exp. Biol.,
March 15, 2005;
208(6):
1063 - 1077.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. M. Cohen
SRC family kinases in cell volume regulation
Am J Physiol Cell Physiol,
March 1, 2005;
288(3):
C483 - C493.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Sheikh-Hamad and M. C. Gustin
MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals
Am J Physiol Renal Physiol,
December 1, 2004;
287(6):
F1102 - F1110.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
V. Plaks, Y. Posen, O. Mazor, A. Brandis, A. Scherz, and Y. Salomon
Homologous Adaptation to Oxidative Stress Induced by the Photosensitized Pd-bacteriochlorophyll Derivative (WST11) in Cultured Endothelial Cells
J. Biol. Chem.,
October 29, 2004;
279(44):
45713 - 45720.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Z. Huang and A. Tunnacliffe
Response of human cells to desiccation: comparison with hyperosmotic stress response
J. Physiol.,
July 1, 2004;
558(1):
181 - 191.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. E. Irarrazabal, J. C. Liu, M. B. Burg, and J. D. Ferraris
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP
PNAS,
June 8, 2004;
101(23):
8809 - 8814.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. A. Kempson, V. Parikh, L. Xi, S. Chu, and M. H. Montrose
Subcellular redistribution of the renal betaine transporter during hypertonic stress
Am J Physiol Cell Physiol,
November 1, 2003;
285(5):
C1091 - C1100.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Rafiee, Y. Shi, K. A. Pritchard Jr., H. Ogawa, A. L. W. Eis, R. A. Komorowski, C. M. Fitzpatrick, J. S. Tweddell, S. B. Litwin, K. Mussatto, et al.
Cellular Redistribution of Inducible Hsp70 Protein in the Human and Rabbit Heart in Response to the Stress of Chronic Hypoxia: ROLE OF PROTEIN KINASES
J. Biol. Chem.,
October 31, 2003;
278(44):
43636 - 43644.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Lopez-Fontanals, S. Rodriguez-Mulero, F. J. Casado, B. Derijard, and M. Pastor-Anglada
The Osmoregulatory and the Amino Acid-regulated Responses of System A Are Mediated by Different Signal Transduction Pathways
J. Gen. Physiol.,
June 30, 2003;
122(1):
5 - 16.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. C. Santos, J. M. Pullman, A. Chevaile, W. J. Welch, and S. R. Gullans
Chronic hyperosmolarity mediates constitutive expression of molecular chaperones and resistance to injury
Am J Physiol Renal Physiol,
March 1, 2003;
284(3):
F564 - F574.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. A. Steinbrecher, J. A. Rudolph, G. Luo, and M. B. Cohen
Coordinate upregulation of guanylin and uroguanylin expression by hypertonicity in HT29-18-N2 cells
Am J Physiol Cell Physiol,
December 1, 2002;
283(6):
C1729 - C1737.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M.-R. Shen, C.-Y. Chou, K.-F. Hsu, and J. C. Ellory
Osmotic Shrinkage of Human Cervical Cancer Cells Induces an Extracellular Cl--dependent Nonselective Cation Channel, Which Requires p38 MAPK
J. Biol. Chem.,
November 22, 2002;
277(48):
45776 - 45784.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. C. B. Ko, A. K. M. Lam, A. Kapus, L. Fan, S. K. Chung, and S. S. M. Chung
Fyn and p38 Signaling Are Both Required for Maximal Hypertonic Activation of the Osmotic Response Element-binding Protein/Tonicity-responsive Enhancer-binding Protein (OREBP/TonEBP)
J. Biol. Chem.,
November 22, 2002;
277(48):
46085 - 46092.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. J. Avdi, K. C. Malcolm, J. A. Nick, and G. S. Worthen
A Role for Protein Phosphatase-2A in p38 Mitogen-activated Protein Kinase-mediated Regulation of the c-Jun NH2-terminal Kinase Pathway in Human Neutrophils
J. Biol. Chem.,
October 18, 2002;
277(43):
40687 - 40696.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Feifel, P. Obexer, M. Andratsch, S. Euler, L. Taylor, A. Tang, Y. Wei, H. Schramek, N. P. Curthoys, and G. Gstraunthaler
p38 MAPK mediates acid-induced transcription of PEPCK in LLC-PK1-FBPase+ cells
Am J Physiol Renal Physiol,
October 1, 2002;
283(4):
F678 - F688.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Zayzafoon, S. Botolin, and L. R. McCabe
p38 and Activating Transcription Factor-2 Involvement in Osteoblast Osmotic Response to Elevated Extracellular Glucose
J. Biol. Chem.,
September 27, 2002;
277(40):
37212 - 37218.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. K. Koul, M. Menon, L. S. Chaturvedi, S. Koul, A. Sekhon, A. Bhandari, and M. Huang
COM Crystals Activate the p38 Mitogen-activated Protein Kinase Signal Transduction Pathway in Renal Epithelial Cells
J. Biol. Chem.,
September 20, 2002;
277(39):
36845 - 36852.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. Tian and D. M. Cohen
Urea stress is more akin to EGF exposure than to hypertonic stress in renal medullary cells
Am J Physiol Renal Physiol,
September 1, 2002;
283(3):
F388 - F398.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. Pan, J. Zarate, and T. M. Bradley
A homolog of the E3 ubiquitin ligase Rbx1 is induced during hyperosmotic stress of salmon
Am J Physiol Regulatory Integrative Comp Physiol,
June 1, 2002;
282(6):
R1643 - R1653.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. S. Chaturvedi, S. Koul, A. Sekhon, A. Bhandari, M. Menon, and H. K. Koul
Oxalate Selectively Activates p38 Mitogen-activated Protein Kinase and c-Jun N-terminal Kinase Signal Transduction Pathways in Renal Epithelial Cells
J. Biol. Chem.,
April 5, 2002;
277(15):
13321 - 13330.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Luss, W. Schmitz, and J. Neumann
A proteasome inhibitor confers cardioprotection
Cardiovasc Res,
April 1, 2002;
54(1):
140 - 151.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
X. Huang, Y. Huang, R. Chinnappan, C. Bocchini, M. C. Gustin, and M. Stern
The Drosophila inebriated-Encoded Neurotransmitter/Osmolyte Transporter: Dual Roles in the Control of Neuronal Excitability and the Osmotic Stress Response
Genetics,
February 1, 2002;
160(2):
561 - 569.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. I. Dmitrieva, D. V. Bulavin, A. J. Fornace Jr., and M. B. Burg
Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase
PNAS,
December 21, 2001;
(2001)
231623498.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Sheikh-Hamad, V. Nadkarni, Y.-J. Choi, L. D. Truong, C. Wideman, R. Hodjati, and K. H. Gabbay
Cyclosporine A Inhibits the Adaptive Responses to Hypertonicity: A Potential Mechanism of Nephrotoxicity
J. Am. Soc. Nephrol.,
December 1, 2001;
12(12):
2732 - 2741.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Kultz
Evolution of Osmosensory MAP Kinase Signaling Pathways
Integr. Comp. Biol.,
August 1, 2001;
41(4):
743 - 757.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. M. Capasso, C. J. Rivard, and T. Berl
Long-term adaptation of renal cells to hypertonicity: role of MAP kinases and Na-K-ATPase
Am J Physiol Renal Physiol,
May 1, 2001;
280(5):
F768 - F776.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. Tian and D. M. Cohen
Urea inhibits hypertonicity-inducible TonEBP expression and action
Am J Physiol Renal Physiol,
May 1, 2001;
280(5):
F904 - F912.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
V. Leitch, P. Agre, and L. S. King
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
PNAS,
February 27, 2001;
98(5):
2894 - 2898.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. C. Dahl, J. S. Handler, and H. M. Kwon
Hypertonicity-induced phosphorylation and nuclear localization of the transcription factor TonEBP
Am J Physiol Cell Physiol,
February 1, 2001;
280(2):
C248 - C253.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P.-G. Petronini, R. R. Alfieri, M. N. Losio, A. E. Caccamo, A. Cavazzoni, M. A. Bonelli, A. F. Borghetti, and K. P. Wheeler
Induction of BGT-1 and amino acid System A transport activities in endothelial cells exposed to hyperosmolarity
Am J Physiol Regulatory Integrative Comp Physiol,
November 1, 2000;
279(5):
R1580 - R1589.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. Tian, Z. Zhang, and D. M. Cohen
MAPK signaling and the kidney
Am J Physiol Renal Physiol,
October 1, 2000;
279(4):
F593 - F604.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F.-X. Beck, W. Neuhofer, and E. Muller
Molecular chaperones in the kidney: distribution, putative roles, and regulation
Am J Physiol Renal Physiol,
August 1, 2000;
279(2):
F203 - F215.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. KIROYCHEVA, F. AHMED, G. M. ANTHONY, C. SZABO, G. J. SOUTHAN, and N. BANK
Mitogen-Activated Protein Kinase Phosphorylation in Kidneys of {beta}s Sickle Cell Mice
J. Am. Soc. Nephrol.,
June 1, 2000;
11(6):
1026 - 1032.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
S. K. Woo, S. C. Dahl, J. S. Handler, and H. M. Kwon
Bidirectional regulation of tonicity-responsive enhancer binding protein in response to changes in tonicity
Am J Physiol Renal Physiol,
June 1, 2000;
278(6):
F1006 - F1012.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. Faccio, A. Chen, C. Fusco, S. Martinotti, J. V. Bonventre, and A. S. Zervos
Mxi2, a splice variant of p38 stress-activated kinase, is a distal nephron protein regulated with kidney ischemia
Am J Physiol Cell Physiol,
April 1, 2000;
278(4):
C781 - C790.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. D. Hoffert, V. Leitch, P. Agre, and L. S. King
Hypertonic Induction of Aquaporin-5 Expression through an ERK-dependent Pathway
J. Biol. Chem.,
March 17, 2000;
275(12):
9070 - 9077.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Li, Y. Hu, G. Sturm, G. Wick, and Q. Xu
Ras/Rac-Dependent Activation of p38 Mitogen-Activated Protein Kinases in Smooth Muscle Cells Stimulated by Cyclic Strain Stress
Arterioscler. Thromb. Vasc. Biol.,
March 1, 2000;
20
(3):
e1 - e9.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. Roger, P.-Y. Martin, M. Rousselot, H. Favre, and E. Feraille
Cell Shrinkage Triggers the Activation of Mitogen-activated Protein Kinases by Hypertonicity in the Rat Kidney Medullary Thick Ascending Limb of the Henle's Loop. REQUIREMENT OF p38 KINASE FOR THE REGULATORY VOLUME INCREASE RESPONSE
J. Biol. Chem.,
November 26, 1999;
274(48):
34103 - 34110.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Franchi-Gazzola, R. Visigalli, O. Bussolati, V. Dall'Asta, and G. C. Gazzola
Adaptive Increase of Amino Acid Transport System A Requires ERK1/2 Activation
J. Biol. Chem.,
October 8, 1999;
274(41):
28922 - 28928.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. P. Dixon, J.-R. Xu, N. Smirnoff, and N. J. Talbot
Independent Signaling Pathways Regulate Cellular Turgor during Hyperosmotic Stress and Appressorium-Mediated Plant Infection by Magnaporthe grisea
PLANT CELL,
October 1, 1999;
11(10):
2045 - 2058.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
X.-Y. Yang, Z. Zhang, and D. M. Cohen
ERK activation by urea in the renal inner medullary mIMCD3 cell line
Am J Physiol Renal Physiol,
August 1, 1999;
277(2):
F176 - F185.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
V. Nadkarni, K. H. Gabbay, K. M. Bohren, and D. Sheikh-Hamad
Osmotic Response Element Enhancer Activity. REGULATION THROUGH p38 KINASE AND MITOGEN-ACTIVATED EXTRACELLULAR SIGNAL-REGULATED KINASE KINASE
J. Biol. Chem.,
July 16, 1999;
274(29):
20185 - 20190.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Kultz and L. Csonka
What sets the TonE during osmotic stress?
PNAS,
March 2, 1999;
96(5):
1814 - 1816.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Miyakawa, S. K. Woo, S. C. Dahl, J. S. Handler, and H. M. Kwon
Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity
PNAS,
March 2, 1999;
96(5):
2538 - 2542.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. D. Ferraris, C. K. Williams, A. Ohtaka, and A. Garcia-Perez
Functional consensus for mammalian osmotic response elements
Am J Physiol Cell Physiol,
March 1, 1999;
276(3):
C667 - C673.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J.-J. Hung, T.-J. Cheng, Y.-K. Lai, and M. D.-T. Chang
Differential Activation of p38 Mitogen-activated Protein Kinase and Extracellular Signal-regulated Protein Kinases Confers Cadmium-induced HSP70 Expression in 9L Rat Brain Tumor Cells
J. Biol. Chem.,
November 27, 1998;
273(48):
31924 - 31931.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Kultz, S. Madhany, and M. B. Burg
Hyperosmolality Causes Growth Arrest of Murine Kidney Cells. INDUCTION OF GADD45 AND GADD153 BY OSMOSENSING VIA STRESS-ACTIVATED PROTEIN KINASE 2
J. Biol. Chem.,
May 29, 1998;
273(22):
13645 - 13651.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Yang, Y. Huang, L. E. Heasley, T. Berl, J. B. Schnermann, and J. P. Briggs
MAPK Mediation of Hypertonicity-stimulated Cyclooxygenase-2 Expression in Renal Medullary Collecting Duct Cells
J. Biol. Chem.,
July 21, 2000;
275(30):
23281 - 23286.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. I. Dmitrieva, D. V. Bulavin, A. J. Fornace Jr., and M. B. Burg
Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase
PNAS,
January 8, 2002;
99(1):
184 - 189.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
O. Nahm, S. K. Woo, J. S. Handler, and H. M. Kwon
Involvement of multiple kinase pathways in stimulation of gene transcription by hypertonicity
Am J Physiol Cell Physiol,
January 1, 2002;
282(1):
C49 - C58.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Zhao, W. Tian, and D. M. Cohen
Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta -independent fashion
Am J Physiol Renal Physiol,
April 1, 2002;
282(4):
F710 - F717.
[Abstract]
[Full Text]
[PDF]
|
 |
|
Copyright © 1998 by the American Society for Biochemistry and Molecular Biology.
|
Advertisement
Advertisement
|