| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 30, 18705-18708, July 24, 1998
,
From the The activation of protein kinase B/Akt is thought
to be a critical step in the phosphoinositide 3-kinase pathway that
regulates cell growth and differentiation. Because insulin-like growth
factor 1 stimulates the resumption of meiosis in Xenopus
laevis oocytes via phosphoinositide 3-kinase activation, we
investigated the Akt involvement in this process. Injection of mRNA
coding for a constitutively active Akt in Xenopus oocytes
induced germinal vesicle breakdown (GVBD) to the same extent as
progesterone or insulin treatment. Injection of mRNA coding for the
wild type Akt kinase was less effective in stimulating GVBD, whereas
Akt bearing a lysine mutation in the catalytic domain that abolishes the kinase activity had no effect. A mutant Akt lacking a
membrane-targeting sequence did not induce GVBD, despite high levels of
expression and activity. As previously reported for insulin, induction
of GVBD by Akt was prevented by incubating the oocytes with
cilostamide, an inhibitor specific for the type 3 phosphodiesterase
(PDE3), suggesting that the activity of a PDE is required for Akt
action. That an increase in PDE activity in the oocyte is sufficient to induce meiotic resumption was demonstrated by expression of an active
PDE protein. In addition, the constitutively active Akt caused a 2-fold
increase in the activity of the endogenous PDE. These data demonstrate
that Akt is in the pathway controlling resumption of meiosis in the
Xenopus oocyte and that regulation of the activity of a
PDE3 is a step distal to the kinase activation.
Department of Gynecology and Obstetrics,
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
This article has been cited by other articles:
|
|
 |
|
  C.-G. Liang, Y.-Q. Su, H.-Y. Fan, H. Schatten, and Q.-Y. Sun Mechanisms Regulating Oocyte Meiotic Resumption: Roles of Mitogen-Activated Protein Kinase Mol. Endocrinol., September 1, 2007; 21(9): 2037 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Pace and P. Thomas Steroid-Induced Oocyte Maturation in Atlantic Croaker (Micropogonias undulatus) Is Dependent on Activation of the Phosphatidylinositol 3-Kinase/Akt Signal Transduction Pathway Biol Reprod, November 1, 2005; 73(5): 988 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nedachi and M. Conti Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation Development, October 15, 2004; 131(20): 4987 - 4998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sarkissian, R. Mendez, and J. D. Richter Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3 Genes & Dev., January 1, 2004; 18(1): 48 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Baert, J.-F. Bodart, B. Bocquet-Muchembled, A. Lescuyer-Rousseau, and J.-P. Vilain Xp42Mpk1 Activation Is Not Required for Germinal Vescicle Breakdown but for Raf Complete Phosphorylation in Insulin-stimulated Xenopus Oocytes J. Biol. Chem., December 12, 2003; 278(50): 49714 - 49720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Hixon and K. Boekelheide Expression and Localization of Total Akt1 and Phosphorylated Akt1 in the Rat Seminiferous Epithelium J Androl, November 1, 2003; 24(6): 891 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Greene, H. Sakaue, L. Wang, D. R. Alessi, and R. A. Roth Modulation of Insulin-stimulated Degradation of Human Insulin Receptor Substrate-1 by Serine 312 Phosphorylation J. Biol. Chem., February 28, 2003; 278(10): 8199 - 8211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Wakefield, D. J. Stephens, and J. M. Tavare A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment J. Cell Sci., February 15, 2003; 116(4): 637 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schmitt and A. R. Nebreda Inhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A PNAS, April 2, 2002; 99(7): 4361 - 4366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Yanochko and A. J. Yool Regulated Cationic Channel Function in Xenopus Oocytes Expressing Drosophila Big Brain J. Neurosci., April 1, 2002; 22(7): 2530 - 2540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Booth, C. Cummings, M. Tiberi, and X. J. Liu GIPC Participates in G Protein Signaling Downstream of Insulin-like Growth Factor 1 Receptor J. Biol. Chem., February 15, 2002; 277(8): 6719 - 6725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Richard, A. Tsafriri, and M. Conti Role of Phosphodiesterase Type 3A in Rat Oocyte Maturation Biol Reprod, November 1, 2001; 65(5): 1444 - 1451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Komalavilas, S. Mehta, C. J. Wingard, D. T. Dransfield, J. Bhalla, J. E. Woodrum, J. R. Molinaro, and C. M. Brophy PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways J Appl Physiol, October 1, 2001; 91(4): 1819 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Finkielstein, A. L. Lewellyn, and J. L. Maller The midblastula transition in Xenopus embryos activates multiple pathways to prevent apoptosis in response to DNA damage PNAS, January 30, 2001; 98(3): 1006 - 1011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Conti Phosphodiesterases and Cyclic Nucleotide Signaling in Endocrine Cells Mol. Endocrinol., September 1, 2000; 14(9): 1317 - 1327. [Full Text]
|
|
|
|
 |
|
 B. Tilton, L. Ho, E. Oberlin, P. Loetscher, F. Baleux, I. Clark-Lewis, and M. Thelen Signal Transduction by CXC Chemokine Receptor 4: Stromal Cell-derived Factor 1 Stimulates Prolonged Protein Kinase B and Extracellular Signal-regulated Kinase 2 Activation in T Lymphocytes J. Exp. Med., July 31, 2000; 192(3): 313 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ahmad, L.-N. Cong, L. Stenson Holst, L.-M. Wang, T. Rahn Landstrom, J. H. Pierce, M. J. Quon, E. Degerman, and V. C. Manganiello Cyclic Nucleotide Phosphodiesterase 3B Is a Downstream Target of Protein Kinase B and May Be Involved in Regulation of Effects of Protein Kinase B on Thymidine Incorporation in FDCP2 Cells J. Immunol., May 1, 2000; 164(9): 4678 - 4688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kitamura, Y. Kitamura, S. Kuroda, Y. Hino, M. Ando, K. Kotani, H. Konishi, H. Matsuzaki, U. Kikkawa, W. Ogawa, et al. Insulin-Induced Phosphorylation and Activation of Cyclic Nucleotide Phosphodiesterase 3B by the Serine-Threonine Kinase Akt Mol. Cell. Biol., September 1, 1999; 19(9): 6286 - 6296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Ahmad, G. Gao, L. M. Wang, T. R. Landstrom, E. Degerman, J. H. Pierce, and V. C. Manganiello IL-3 and IL-4 Activate Cyclic Nucleotide Phosphodiesterases 3 (PDE3) and 4 (PDE4) by Different Mechanisms in FDCP2 Myeloid Cells J. Immunol., April 15, 1999; 162(8): 4864 - 4875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shakur, K. Takeda, Y. Kenan, Z.-X. Yu, G. Rena, D. Brandt, M. D. Houslay, E. Degerman, V. J. Ferrans, and V. C. Manganiello Membrane Localization of Cyclic Nucleotide Phosphodiesterase 3 (PDE3). TWO N-TERMINAL DOMAINS ARE REQUIRED FOR THE EFFICIENT TARGETING TO, AND ASSOCIATION OF, PDE3 WITH ENDOPLASMIC RETICULUM J. Biol. Chem., December 1, 2000; 275(49): 38749 - 38761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsumoto, W. Ogawa, Y. Hino, K. Furukawa, Y. Ono, M. Takahashi, M. Ohba, T. Kuroki, and M. Kasuga Inhibition of Insulin-induced Activation of Akt by a Kinase-deficient Mutant of the epsilon Isozyme of Protein Kinase C J. Biol. Chem., April 20, 2001; 276(17): 14400 - 14406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schmitt and A. R. Nebreda Inhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A PNAS, April 2, 2002; 99(7): 4361 - 4366. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
