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J Biol Chem, Vol. 273, Issue 32, 20150-20155, August 7, 1998
From the Institut für Physiologische Chemie, Physikalische
Biochemie und Zellbiologie der Universität München,
Goethestra Fzo1p is a novel component required for the
biogenesis of functional mitochondria in the yeast Saccharomyces
cerevisiae. The protein is homologous to Drosophila
Fzo, the first known protein mediator of mitochondrial fusion. Deletion
of the FZO1 gene results in a petite phenotype, loss of
mitochondrial DNA, and a fragmented mitochondrial morphology. Fzo1p is
an integral protein of the mitochondrial outer membrane exposing its
major part to the cytosol. It is imported into the outer membrane in a
receptor-dependent manner. Fzo1p is part of a larger
protein complex of 800 kDa, and presumably is the first identified
component of the yeast mitochondrial fusion machinery.
Fzo1p Is a Mitochondrial Outer Membrane Protein Essential for the
Biogenesis of Functional Mitochondria in Saccharomyces
cerevisiae
e 33, 80336 München, Germany
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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