| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 32, 20448-20455, August 7, 1998
From the a Department of Molecular Pharmacology and the
c Departments of Developmental and Molecular Biology and
Medicine, Albert Einstein Cancer Center, Albert Einstein College of
Medicine, Bronx, New York 10461, the e Cancer Therapy and
Research Center, San Antonio, Texas 78229, and the
g Department of Pathology, McMaster University, West
Hamilton, Ontario L8S 4K1, Canada
Neu (c-erbB2) is a
proto-oncogene product that encodes an epidermal growth factor-like
receptor tyrosine kinase. Amplification of wild-type c-Neu
and mutational activation of Neu (Neu T) have been implicated in oncogenic transformation of cultured fibroblasts and
mammary tumorigenesis in vivo. Here, we examine the
relationship between Neu tyrosine kinase activity and caveolin-1
protein expression in vitro and in vivo. Recent
studies have suggested that caveolins may function as negative
regulators of signal transduction. Our current results show that
mutational activation of c-Neu down-regulates caveolin-1 protein
expression, but not caveolin-2, in cultured NIH 3T3 and Rat 1 cells.
Conversely, recombinant overexpression of caveolin-1 blocks
Neu-mediated signal transduction in vivo. These results
suggest a reciprocal relationship between c-Neu tyrosine kinase
activity and caveolin-1 protein expression. We next analyzed a variety
of caveolin-1 deletion mutants to map this
caveolin-1-dependent inhibitory activity to a given region of the caveolin-1 molecule. Results from this mutational analysis show
that this functional in vivo inhibitory activity is
contained within caveolin-1 residues 32-95. In accordance with these
in vivo studies, a 20-amino acid peptide derived from this
region (the caveolin-1 scaffolding domain) was sufficient to inhibit Neu autophosphorylation in an in vitro kinase assay. To
further confirm or refute the relevance of our findings in
vivo, we next examined the expression levels of caveolin-1 in
mammary tumors derived from c-Neu transgenic mice. Our results indicate
that dramatic reduction of caveolin-1 expression occurs in mammary tumors derived from c-Neu-expressing transgenic mice and other transgenic mice expressing downstream effectors of Neu-mediated signal
transduction, such as Src and Ras. Taken together, our data suggest
that a novel form of reciprocal negative regulation exists between
c-Neu and caveolin-1.
Reciprocal Regulation of Neu Tyrosine Kinase Activity and
Caveolin-1 Protein Expression in Vitro and in
Vivo
IMPLICATIONS FOR HUMAN BREAST CANCER
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Golipour, D. Myers, T. Seagroves, D. Murphy, G. I. Evan, D. J. Donoghue, R. A. Moorehead, and L. A. Porter The Spy1/RINGO Family Represents a Novel Mechanism Regulating Mammary Growth and Tumorigenesis Cancer Res., May 15, 2008; 68(10): 3591 - 3600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bianco, L. Strizzi, M. Mancino, K. Watanabe, M. Gonzales, S. Hamada, A. Raafat, L. Sahlah, C. Chang, F. Sotgia, et al. Regulation of Cripto-1 Signaling and Biological Activity by Caveolin-1 in Mammary Epithelial Cells Am. J. Pathol., February 1, 2008; 172(2): 345 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Forbes, M. Wadehra, S. Mareninov, S. Morales, K. Shimazaki, L. K. Gordon, and J. Braun The Tetraspan Protein EMP2 Regulates Expression of Caveolin-1 J. Biol. Chem., September 7, 2007; 282(36): 26542 - 26551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Costa, M. Senou, F. Van Rode, J. Ruf, M. Capello, D. Dequanter, P. Lothaire, C. Dessy, J. E. Dumont, M.-C. Many, et al. Reciprocal Negative Regulation between Thyrotropin/3',5'-Cyclic Adenosine Monophosphate-Mediated Proliferation and Caveolin-1 Expression in Human and Murine Thyrocytes Mol. Endocrinol., April 1, 2007; 21(4): 921 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dasari, J. N. Bartholomew, D. Volonte, and F. Galbiati Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated Protein Kinase/Sp1-Mediated Activation of Two GC-Rich Promoter Elements. Cancer Res., November 15, 2006; 66(22): 10805 - 10814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Williams, F. Sotgia, H. Lee, G. Hassan, D. Di Vizio, G. Bonuccelli, F. Capozza, I. Mercier, H. Rui, R. G. Pestell, et al. Stromal and Epithelial Caveolin-1 Both Confer a Protective Effect Against Mammary Hyperplasia and Tumorigenesis: Caveolin-1 Antagonizes Cyclin D1 Function in Mammary Epithelial Cells Am. J. Pathol., November 1, 2006; 169(5): 1784 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Li, F. Sotgia, M. A. Vuolo, M. Li, W. C. Yang, R. G. Pestell, J. A. Sparano, and M. P. Lisanti Caveolin-1 Mutations in Human Breast Cancer: Functional Association with Estrogen Receptor {alpha}-Positive Status Am. J. Pathol., June 1, 2006; 168(6): 1998 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Konopleva, W. Zhang, Y.-X. Shi, T. McQueen, T. Tsao, M. Abdelrahim, M. F. Munsell, M. Johansen, D. Yu, T. Madden, et al. Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells. Mol. Cancer Ther., February 1, 2006; 5(2): 317 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sotgia, T. M. Williams, W. Schubert, F. Medina, C. Minetti, R. G. Pestell, and M. P. Lisanti Caveolin-1 Deficiency (-/-) Conveys Premalignant Alterations in Mammary Epithelia, with Abnormal Lumen Formation, Growth Factor Independence, and Cell Invasiveness Am. J. Pathol., January 1, 2006; 168(1): 292 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Dobrowsky, S. Rouen, and C. Yu Altered Neurotrophism in Diabetic Neuropathy: Spelunking the Caves of Peripheral Nerve J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 485 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Williams and M. P. Lisanti Caveolin-1 in oncogenic transformation, cancer, and metastasis Am J Physiol Cell Physiol, March 1, 2005; 288(3): C494 - C506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Williams, F. Medina, I. Badano, R. B. Hazan, J. Hutchinson, W. J. Muller, N. G. Chopra, P. E. Scherer, R. G. Pestell, and M. P. Lisanti Caveolin-1 Gene Disruption Promotes Mammary Tumorigenesis and Dramatically Enhances Lung Metastasis in Vivo: ROLE OF CAV-1 IN CELL INVASIVENESS AND MATRIX METALLOPROTEINASE (MMP-2/9) SECRETION J. Biol. Chem., December 3, 2004; 279(49): 51630 - 51646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Cohen, R. Hnasko, W. Schubert, and M. P. Lisanti Role of Caveolae and Caveolins in Health and Disease Physiol Rev, October 1, 2004; 84(4): 1341 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kim, R. M. Adam, K. R. Solomon, and M. R. Freeman Involvement of Cholesterol-Rich Lipid Rafts in Interleukin-6-Induced Neuroendocrine Differentiation of LNCaP Prostate Cancer Cells Endocrinology, February 1, 2004; 145(2): 613 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hnasko and M. P. Lisanti The Biology of Caveolae: Lessons from Caveolin Knockout Mice and Implications for Human Disease Mol. Interv., December 1, 2003; 3(8): 445 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Volonte, A. J. Peoples, and F. Galbiati Modulation of Myoblast Fusion by Caveolin-3 in Dystrophic Skeletal Muscle Cells: Implications for Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy-1C Mol. Biol. Cell, October 1, 2003; 14(10): 4075 - 4088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xie, X. Zeng, T. Waldman, and R. I. Glazer Transformation of Mammary Epithelial Cells by 3-Phosphoinositide- dependent Protein Kinase-1 Activates {beta}-Catenin and c-Myc, and Down-Regulates Caveolin-1 Cancer Res., September 1, 2003; 63(17): 5370 - 5375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Tan, S. Rouen, K. M. Barkus, Y. S. Dremina, D. Hui, J. A. Christianson, D. E. Wright, S. O. Yoon, and R. T. Dobrowsky Nerve Growth Factor Blocks the Glucose-induced Down-regulation of Caveolin-1 Expression in Schwann Cells via p75 Neurotrophin Receptor Signaling J. Biol. Chem., June 13, 2003; 278(25): 23151 - 23162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Capozza, T. M. Williams, W. Schubert, S. McClain, B. Bouzahzah, F. Sotgia, and M. P. Lisanti Absence of Caveolin-1 Sensitizes Mouse Skin to Carcinogen-Induced Epidermal Hyperplasia and Tumor Formation Am. J. Pathol., June 1, 2003; 162(6): 2029 - 2039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Williams, M. W.-C. Cheung, D. S. Park, B. Razani, A. W. Cohen, W. J. Muller, D. Di Vizio, N. G. Chopra, R. G. Pestell, and M. P. Lisanti Loss of Caveolin-1 Gene Expression Accelerates the Development of Dysplastic Mammary Lesions in Tumor-Prone Transgenic Mice Mol. Biol. Cell, March 1, 2003; 14(3): 1027 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Cohen, D. S. Park, S. E. Woodman, T. M. Williams, M. Chandra, J. Shirani, A. Pereira de Souza, R. N. Kitsis, R. G. Russell, L. M. Weiss, et al. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts Am J Physiol Cell Physiol, February 1, 2003; 284(2): C457 - C474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Labrecque, I. Royal, D. S. Surprenant, C. Patterson, D. Gingras, and R. Beliveau Regulation of Vascular Endothelial Growth Factor Receptor-2 Activity by Caveolin-1 and Plasma Membrane Cholesterol Mol. Biol. Cell, January 1, 2003; 14(1): 334 - 347. [Abstract] [Full Text]
|
|
|
|
|
|
J. Zschocke, D. Manthey, N. Bayatti, B. van der Burg, S. Goodenough, and C. Behl Estrogen Receptor alpha -mediated Silencing of Caveolin Gene Expression in Neuronal Cells J. Biol. Chem., October 4, 2002; 277(41): 38772 - 38780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lee, D. S. Park, B. Razani, R. G. Russell, R. G. Pestell, and M. P. Lisanti Caveolin-1 Mutations (P132L and Null) and the Pathogenesis of Breast Cancer : Caveolin-1 (P132L) Behaves in a Dominant-Negative Manner and Caveolin-1 (-/-) Null Mice Show Mammary Epithelial Cell Hyperplasia Am. J. Pathol., October 1, 2002; 161(4): 1357 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Park, H. Lee, P. G. Frank, B. Razani, A. V. Nguyen, A. F. Parlow, R. G. Russell, J. Hulit, R. G. Pestell, and M. P. Lisanti Caveolin-1-deficient Mice Show Accelerated Mammary Gland Development During Pregnancy, Premature Lactation, and Hyperactivation of the Jak-2/STAT5a Signaling Cascade Mol. Biol. Cell, October 1, 2002; 13(10): 3416 - 3430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Razani, S. E. Woodman, and M. P. Lisanti Caveolae: From Cell Biology to Animal Physiology Pharmacol. Rev., September 1, 2002; 54(3): 431 - 467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Volonte, K. Zhang, M. P. Lisanti, and F. Galbiati Expression of Caveolin-1 Induces Premature Cellular Senescence in Primary Cultures of Murine Fibroblasts. Stress-Induced Premature Senescence Upregulates the Expression of Endogenous Caveolin-1 Mol. Biol. Cell, July 1, 2002; 13(7): 2502 - 2517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Park, S. E. Woodman, W. Schubert, A. W. Cohen, P. G. Frank, M. Chandra, J. Shirani, B. Razani, B. Tang, L. A. Jelicks, et al. Caveolin-1/3 Double-Knockout Mice Are Viable, but Lack Both Muscle and Non-Muscle Caveolae, and Develop a Severe Cardiomyopathic Phenotype Am. J. Pathol., June 1, 2002; 160(6): 2207 - 2217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gana-Weisz, J. Halaschek-Wiener, B. Jansen, G. Elad, R. Haklai, and Y. Kloog The Ras Inhibitor S-trans,trans-Farnesylthiosalicylic Acid Chemosensitizes Human Tumor Cells Without Causing Resistance Clin. Cancer Res., February 1, 2002; 8(2): 555 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Park, H. Lee, C. Riedel, J. Hulit, P. E. Scherer, R. G. Pestell, and M. P. Lisanti Prolactin Negatively Regulates Caveolin-1 Gene Expression in the Mammary Gland during Lactation, via a Ras-dependent Mechanism J. Biol. Chem., December 14, 2001; 276(51): 48389 - 48397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Razani and M. P. Lisanti Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A Am J Physiol Cell Physiol, October 1, 2001; 281(4): C1241 - C1250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Galbiati, D. Volonte', J. Liu, F. Capozza, P. G. Frank, L. Zhu, R. G. Pestell, and M. P. Lisanti Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G0/G1 Arrest via a p53/p21WAF1/Cip1-dependent Mechanism Mol. Biol. Cell, August 1, 2001; 12(8): 2229 - 2244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Frank, F. Galbiati, D. Volonte, B. Razani, D. E. Cohen, Y. L. Marcel, and M. P. Lisanti Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins Am J Physiol Cell Physiol, May 1, 2001; 280(5): C1204 - C1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, P. Lee, F. Galbiati, R. N. Kitsis, and M. P. Lisanti Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation Am J Physiol Cell Physiol, April 1, 2001; 280(4): C823 - C835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lee, D. Volonte’, F. Galbiati, P. Iyengar, D. M. Lublin, D. B. Bregman, M. T. Wilson, R. Campos-Gonzalez Boumediene Bouzahzah, R. G. Pestell, P. E. Scherer, et al. Constitutive and Growth Factor-Regulated Phosphorylation of Caveolin-1 Occurs at the Same Site (Tyr-14) in Vivo: Identification of a c-Src/Cav-1/Grb7 Signaling Cassette Mol. Endocrinol., November 1, 2000; 14(11): 1750 - 1775. [Abstract] [Full Text]
|
|
|
|
|
|
F. C. Bender, M. A. Reymond, C. Bron, and A. F. G. Quest Caveolin-1 Levels Are Down-Regulated in Human Colon Tumors, and Ectopic Expression of Caveolin-1 in Colon Carcinoma Cell Lines Reduces Cell Tumorigenicity Cancer Res., October 1, 2000; 60(20): 5870 - 5878. [Abstract] [Full Text]
|
|
|
|
 |
|
 B Razani, A Schlegel, and M. Lisanti Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy J. Cell Sci., January 6, 2000; 113(12): 2103 - 2109. [Abstract] [PDF]
|
|
|
|
|
|
S Miotti, M Bagnoli, A Tomassetti, M. Colnaghi, and S Canevari Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1 J. Cell Sci., January 1, 2000; 113(2): 349 - 357. [Abstract] [PDF]
|
|
|
|
|
|
F. H. Nystrom, H. Chen, L.-N. Cong, Y. Li, and M. J. Quon Caveolin-1 Interacts with the Insulin Receptor and Can Differentially Modulate Insulin Signaling in Transfected Cos-7 Cells and Rat Adipose Cells Mol. Endocrinol., December 1, 1999; 13(12): 2013 - 2024. [Abstract] [Full Text]
|
|
|
|
|
|
A. Schlegel, C. Wang, B. S. Katzenellenbogen, R. G. Pestell, and M. P. Lisanti Caveolin-1 Potentiates Estrogen Receptor alpha (ERalpha ) Signaling. CAVEOLIN-1 DRIVES LIGAND-INDEPENDENT NUCLEAR TRANSLOCATION AND ACTIVATION OF ERalpha J. Biol. Chem., November 19, 1999; 274(47): 33551 - 33556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Engelman, X. L. Zhang, B. Razani, R. G. Pestell, and M. P. Lisanti p42/44 MAP Kinase-dependent and -independent Signaling Pathways Regulate Caveolin-1 Gene Expression. ACTIVATION OF RAS-MAP KINASE AND PROTEIN KINASE A SIGNALING CASCADES TRANSCRIPTIONALLY DOWN-REGULATES CAVEOLIN-1 PROMOTER ACTIVITY J. Biol. Chem., November 5, 1999; 274(45): 32333 - 32341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Smart, G. A. Graf, M. A. McNiven, W. C. Sessa, J. A. Engelman, P. E. Scherer, T. Okamoto, and M. P. Lisanti Caveolins, Liquid-Ordered Domains, and Signal Transduction Mol. Cell. Biol., November 1, 1999; 19(11): 7289 - 7304. [Full Text] [PDF]
|
|
|
|
|
|
F. Galbiati, D. Volonte, J. A. Engelman, P. E. Scherer, and M. P. Lisanti Targeted Down-regulation of Caveolin-3 Is Sufficient to Inhibit Myotube Formation in Differentiating C2C12 Myoblasts. TRANSIENT ACTIVATION OF p38 MITOGEN-ACTIVATED PROTEIN KINASE IS REQUIRED FOR INDUCTION OF CAVEOLIN-3 EXPRESSION AND SUBSEQUENT MYOTUBE FORMATION J. Biol. Chem., October 15, 1999; 274(42): 30315 - 30321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Razani, C. S. Rubin, and M. P. Lisanti Regulation of cAMP-mediated Signal Transduction via Interaction of Caveolins with the Catalytic Subunit of Protein Kinase A J. Biol. Chem., September 10, 1999; 274(37): 26353 - 26360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schlegel, R. B. Schwab, P. E. Scherer, and M. P. Lisanti A Role for the Caveolin Scaffolding Domain in Mediating the Membrane Attachment of Caveolin-1. THE CAVEOLIN SCAFFOLDING DOMAIN IS BOTH NECESSARY AND SUFFICIENT FOR MEMBRANE BINDING IN VITRO J. Biol. Chem., August 6, 1999; 274(32): 22660 - 22667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, B. Razani, S. Tang, B. I. Terman, J. A. Ware, and M. P. Lisanti Angiogenesis Activators and Inhibitors Differentially Regulate Caveolin-1 Expression and Caveolae Formation in Vascular Endothelial Cells. ANGIOGENESIS INHIBITORS BLOCK VASCULAR ENDOTHELIAL GROWTH FACTOR-INDUCED DOWN-REGULATION OF CAVEOLIN-1 J. Biol. Chem., May 28, 1999; 274(22): 15781 - 15785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Carman, M. P. Lisanti, and J. L. Benovic Regulation of G Protein-coupled Receptor Kinases by Caveolin J. Biol. Chem., March 26, 1999; 274(13): 8858 - 8864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Galbiati, D. Volonte, O. Gil, G. Zanazzi, J. L. Salzer, M. Sargiacomo, P. E. Scherer, J. A. Engelman, A. Schlegel, M. Parenti, et al. Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: Caveolin-2 is up-regulated in response to cell injury PNAS, August 18, 1998; 95(17): 10257 - 10262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hulit, T. Bash, M. Fu, F. Galbiati, C. Albanese, D. R. Sage, A. Schlegel, J. Zhurinsky, M. Shtutman, A. Ben-Ze'ev, et al. The Cyclin D1 Gene Is Transcriptionally Repressed by Caveolin-1 J. Biol. Chem., July 7, 2000; 275(28): 21203 - 21209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Galbiati, D. Volonte', A. M. C. Brown, D. E. Weinstein, A. Ben-Ze'ev, R. G. Pestell, and M. P. Lisanti Caveolin-1 Expression Inhibits Wnt/beta -Catenin/Lef-1 Signaling by Recruiting beta -Catenin to Caveolae Membrane Domains J. Biol. Chem., July 21, 2000; 275(30): 23368 - 23377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Lu, M. C. Schneider, Y. Zheng, X. Zhang, and J. P. Richie Caveolin-1 Interacts with Androgen Receptor. A POSITIVE MODULATOR OF ANDROGEN RECEPTOR MEDIATED TRANSACTIVATION J. Biol. Chem., April 13, 2001; 276(16): 13442 - 13451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Razani, X. L. Zhang, M. Bitzer, G. von Gersdorff, E. P. Bottinger, and M. P. Lisanti Caveolin-1 Regulates Transforming Growth Factor (TGF)-beta /SMAD Signaling through an Interaction with the TGF-beta Type I Receptor J. Biol. Chem., February 23, 2001; 276(9): 6727 - 6738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Razani, J. A. Engelman, X. B. Wang, W. Schubert, X. L. Zhang, C. B. Marks, F. Macaluso, R. G. Russell, M. Li, R. G. Pestell, et al. Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities J. Biol. Chem., October 5, 2001; 276(41): 38121 - 38138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhang, B. Razani, Y. Altschuler, B. Bouzahzah, K. E. M |
