| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 33, 20721-20727, August 14, 1998
From the The Hakata antigen is a novel, thermolabile
Cloning and Characterization of the Hakata Antigen, a Member
of the Ficolin/Opsonin p35 Lectin Family
,,,,,,,, and
Department of Clinical Chemistry and
Laboratory Medicine, and the ¶ Department of Anatomy, Faculty of
Medicine, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka
812-8582, Japan
2-macroglycoprotein that reacts with sera from
patients suffering from systemic lupus erythematosus. In this study we
present the structure and the function of the Hakata antigen. We have
identified cDNA clones encoding the Hakata antigen and analyzed its
function. The cDNA included a possible open reading frame of 897 nucleotides, encoding 299 amino acids. The Hakata antigen consisted of
a collagen-like domain in the middle section and a fibrinogen-like
domain in the COOH terminus, both of which are homologous to human
ficolin-1 and opsonin P35, indicating that these three molecules form a distinct family. The molecular mass of the Hakata antigen expressed in
transfected cells was 35 kDa under reduced conditions, and it formed
ladder bands under nonreducing conditions compatible with the previous
result that the Hakata antigen exists in serum as homopolymers.
Purified Hakata antigen sustained lectin activity, showing affinity
with GalNAc, GlcNAc, D-fucose as mono/oligosaccharide, and
lipopolysaccharides from Salmonella typhimurium and
Salmonella minnesota. These results suggest that the Hakata
antigen, a new member of the ficolin/opsonin P35 family, plays a role
in the serum exerting lectin activity under physiological
conditions.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Tanio, S. Kondo, S. Sugio, and T. Kohno Trivalent Recognition Unit of Innate Immunity System: CRYSTAL STRUCTURE OF TRIMERIC HUMAN M-FICOLIN FIBRINOGEN-LIKE DOMAIN J. Biol. Chem., February 9, 2007; 282(6): 3889 - 3895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Imai, S. Nishi, B. Alchi, M. Ueno, S. Fukase, M. Arakawa, K. Saito, K. Takahashi, and F. Gejyo Immunohistochemical evidence of activated lectin pathway in kidney allografts with peritubular capillary C4d deposition Nephrol. Dial. Transplant., September 1, 2006; 21(9): 2589 - 2595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. L. Runza, T. Hehlgans, B. Echtenacher, U. Zahringer, W. J. Schwaeble, and D. N. Mannel Localization of the mouse defense lectin ficolin B in lysosomes of activated macrophages Innate Immunity, April 1, 2006; 12(2): 120 - 126. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Liu, Y. Endo, D. Iwaki, M. Nakata, M. Matsushita, I. Wada, K. Inoue, M. Munakata, and T. Fujita Human M-Ficolin Is a Secretory Protein That Activates the Lectin Complement Pathway J. Immunol., September 1, 2005; 175(5): 3150 - 3156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hummelshoj, L. Munthe-Fog, H. O. Madsen, T. Fujita, M. Matsushita, and P. Garred Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2 Hum. Mol. Genet., June 15, 2005; 14(12): 1651 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nagata Isolation, characterization, and extra-embryonic secretion of the Xenopus laevis embryonic epidermal lectin, XEEL Glycobiology, March 1, 2005; 15(3): 281 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Krarup, U. B. S. Sorensen, M. Matsushita, J. C. Jensenius, and S. Thiel Effect of Capsulation of Opportunistic Pathogenic Bacteria on Binding of the Pattern Recognition Molecules Mannan-Binding Lectin, L-Ficolin, and H-Ficolin Infect. Immun., February 1, 2005; 73(2): 1052 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Aoyagi, E. E. Adderson, J. G. Min, M. Matsushita, T. Fujita, S. Takahashi, Y. Okuwaki, and J. F. Bohnsack Role of L-Ficolin/Mannose-Binding Lectin-Associated Serine Protease Complexes in the Opsonophagocytosis of Type III Group B Streptococci J. Immunol., January 1, 2005; 174(1): 418 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Krarup, S. Thiel, A. Hansen, T. Fujita, and J. C. Jensenius L-ficolin Is a Pattern Recognition Molecule Specific for Acetyl Groups J. Biol. Chem., November 12, 2004; 279(46): 47513 - 47519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wallis, J. M. Shaw, J. Uitdehaag, C.-B. Chen, D. Torgersen, and K. Drickamer Localization of the Serine Protease-binding Sites in the Collagen-like Domain of Mannose-binding Protein: INDIRECT EFFECTS OF NATURALLY OCCURRING MUTATIONS ON PROTEASE BINDING AND ACTIVATION J. Biol. Chem., April 2, 2004; 279(14): 14065 - 14073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ohashi and H. P. Erickson The Disulfide Bonding Pattern in Ficolin Multimers J. Biol. Chem., February 20, 2004; 279(8): 6534 - 6539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Lynch, S. Roscher, T. Hartung, S. Morath, M. Matsushita, D. N. Maennel, M. Kuraya, T. Fujita, and W. J. Schwaeble L-Ficolin Specifically Binds to Lipoteichoic Acid, a Cell Wall Constituent of Gram-Positive Bacteria, and Activates the Lectin Pathway of Complement J. Immunol., January 15, 2004; 172(2): 1198 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Endo, M. Nonaka, H. Saiga, Y. Kakinuma, A. Matsushita, M. Takahashi, M. Matsushita, and T. Fujita Origin of Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 and MASP-3 Involved in the Lectin Complement Pathway Traced Back to the Invertebrate, Amphioxus J. Immunol., May 1, 2003; 170(9): 4701 - 4707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cseh, L. Vera, M. Matsushita, T. Fujita, G. J. Arlaud, and N. M. Thielens Characterization of the Interaction Between L-Ficolin/P35 and Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 J. Immunol., November 15, 2002; 169(10): 5735 - 5743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Endo, M. Takahashi, M. Kuraya, M. Matsushita, C. M. Stover, W. J. Schwaeble, and T. Fujita Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter Int. Immunol., October 1, 2002; 14(10): 1193 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsushita, M. Kuraya, N. Hamasaki, M. Tsujimura, H. Shiraki, and T. Fujita Activation of the Lectin Complement Pathway by H-Ficolin (Hakata Antigen) J. Immunol., April 1, 2002; 168(7): 3502 - 3506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tsujimura, C. Ishida, Y. Sagara, T. Miyazaki, K. Murakami, H. Shiraki, K. Okochi, and Y. Maeda Detection of Serum Thermolabile {beta}-2 Macroglycoprotein (Hakata Antigen) by Enzyme-Linked Immunosorbent Assay Using Polysaccharide Produced by Aerococcus viridans Clin. Vaccine Immunol., March 1, 2001; 8(2): 454 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-K. Lee, J. Schnee, M. Pang, M. Wolfert, L. G. Baum, K. W. Moremen, and M. Pierce Human homologs of the Xenopus oocyte cortical granule lectin XL35 Glycobiology, January 1, 2001; 11(1): 65 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsushita, Y. Endo, and T. Fujita Cutting Edge: Complement-Activating Complex of Ficolin and Mannose-Binding Lectin-Associated Serine Protease J. Immunol., March 1, 2000; 164(5): 2281 - 2284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kim, S.-O. Moon, K. N. Koh, H. Kim, C.-S. Uhm, H. J. Kwak, N.-G. Kim, and G. Y. Koh Molecular Cloning, Expression, and Characterization of Angiopoietin-related Protein. ANGIOPOIETIN-RELATED PROTEIN INDUCES ENDOTHELIAL CELL SPROUTING J. Biol. Chem., September 10, 1999; 274(37): 26523 - 26528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Butko, A. Nicholson-Weller, and M. R. Wessels Role of Complement Component C1q in the IgG-Independent Opsonophagocytosis of Group B Streptococcus J. Immunol., September 1, 1999; 163(5): 2761 - 2768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gokudan, T. Muta, R. Tsuda, K. Koori, T. Kawahara, N. Seki, Y. Mizunoe, S. N. Wai, S. Iwanaga, and S.-i. Kawabata Horseshoe crab acetyl group-recognizing lectins involved in innate immunity are structurally related to fibrinogen PNAS, August 31, 1999; 96(18): 10086 - 10091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Akaiwa, Y. Yae, R. Sugimoto, S. O. Suzuki, T. Iwaki, K. Izuhara, and N. Hamasaki Hakata Antigen, a New Member of the Ficolin/Opsonin p35 Family, Is a Novel Human Lectin Secreted into Bronchus/Alveolus and Bile J. Histochem. Cytochem., June 1, 1999; 47(6): 777 - 786. [Abstract] [Full Text]
|
|
|
|
|
|
A. Kenjo, M. Takahashi, M. Matsushita, Y. Endo, M. Nakata, T. Mizuochi, and T. Fujita Cloning and Characterization of Novel Ficolins from the Solitary Ascidian, Halocynthia roretzi J. Biol. Chem., June 1, 2001; 276(23): 19959 - 19965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsuji, J. Uehori, M. Matsumoto, Y. Suzuki, A. Matsuhisa, K. Toyoshima, and T. Seya Human Intelectin Is a Novel Soluble Lectin That Recognizes Galactofuranose in Carbohydrate Chains of Bacterial Cell Wall J. Biol. Chem., June 22, 2001; 276(26): 23456 - 23463. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
