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J Biol Chem, Vol. 273, Issue 33, 21132-21136, August 14, 1998
From the The tax gene product of human T-cell
leukemia virus I induces aberrant expression of various cellular genes,
which contributes to transformation of host cells. Induction of many
Tax target genes is mediated through transcription factor NF-
NF-
B-inducing Kinase and IB Kinase Participate in Human
T-cell Leukemia Virus I Tax-mediated NF-B Activation
,,,,
Department of Microbiology and Immunology,
Pennsylvania State University College of Medicine, Hershey,
Pennsylvania 17033 and the ** Department of Pharmacology, Laboratory of
Gene Regulation and Signal Transduction, University of California at
San Diego, La Jolla, California 92093-0636
B. Here
we show that Tax triggers activation of cellular protein kinases, IB
kinase 
(IKK) and IKK
, which phosphorylate the NF-B
inhibitory protein IB, resulting in its degradation and NF-B
activation. Constitutive IKK activation occurs in both Tax-transfected
and human T-cell leukemia virus I-infected T cells. We further
demonstrate that Tax-mediated NF-B signaling also requires the
NF-B-inducing kinase (NIK). Consistently, inactive forms of either
IKKs or NIK attenuate Tax-mediated NF-B activation. Therefore, Tax
activates NF-B by targeting cellular signaling molecules, including
both IKKs and NIK.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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