| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 33, 21145-21152, August 14, 1998
From the Smad proteins have been identified as mediators
of intracellular signal transduction by members of the transforming
growth factor-
Identification and Functional Characterization of a Smad Binding
Element (SBE) in the JunB Promoter That Acts as a
Transforming Growth Factor-
, Activin, and Bone Morphogenetic
Protein-inducible Enhancer
,
Department of Developmental Genetics,
Groningen Biomolecular Sciences and Biotechnology Institute, P. O. Box
14, 9750 AA Haren, The Netherlands and the ¶ Ludwig Institute for
Cancer Research, Box 595, Biomedical Center, S-75,
24 Uppsala, Sweden
(TGF-) superfamily, which affect cell
proliferation, differentiation, as well as pattern formation during
early vertebrate development. Following receptor activation, Smads are
assembled into heteromeric complexes consisting of a pathway-restricted Smad and the common Smad4 that are subsequently translocated into the
nucleus where they are thought to play an important role in gene
transcription. Here we report the identification of Smad Binding
Elements (SBEs) composed of the sequence CAGACA in the promoter of the
JunB gene, an immediate early gene that is potently induced
by TGF-, activin, and bone morphogenetic protein (BMP) 2. Two
JunB SBEs are arranged as an inverted repeat that is
transactivated in response to Smad3 and Smad4 co-overexpression and
shows inducible binding of a Smad3- and Smad4-containing complex in
nuclear extracts from TGF--treated cells. Bacterial-expressed Smad
proteins bind directly to the SBE. Multimerization of the SBE creates a
powerful TGF--inducible enhancer that is also responsive to activin
and BMPs. The identification of the sequence CAGACA as a direct binding site for Smad proteins will facilitate the identification of regulatory elements in genes that are activated by members of the TGF-
superfamily.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Thompson, S. McMahon, Y. Bosse, C. M. Dubois, J. Stankova, and M. Rola-Pleszczynski Leukotriene D4 Up-Regulates Furin Expression through CysLT1 Receptor Signaling Am. J. Respir. Cell Mol. Biol., August 1, 2008; 39(2): 227 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Khan, M. S. Nelson, C. Pan, P. M. Gaffney, and P. Gupta Endogenous heparan sulfate and heparin modulate bone morphogenetic protein-4 signaling and activity Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1387 - C1397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hu, M. Milstein, J. M. Bliss, M. Thai, G. Malhotra, L. C. Huynh, and J. Colicelli Integration of Transforming Growth Factor {beta} and RAS Signaling Silences a RAB5 Guanine Nucleotide Exchange Factor and Enhances Growth Factor-Directed Cell Migration Mol. Cell. Biol., March 1, 2008; 28(5): 1573 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Shukla, Y. Ho, X. Liu, A. Ryscavage, and A. B. Glick Cripto-1 Alters Keratinocyte Differentiation via Blockade of Transforming Growth Factor-{beta}1 Signaling: Role in Skin Carcinogenesis Mol. Cancer Res., March 1, 2008; 6(3): 509 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Buijs, C. A. Rentsch, G. van der Horst, P. G.M. van Overveld, A. Wetterwald, R. Schwaninger, N. V. Henriquez, P. ten Dijke, F. Borovecki, R. Markwalder, et al. BMP7, a Putative Regulator of Epithelial Homeostasis in the Human Prostate, Is a Potent Inhibitor of Prostate Cancer Bone Metastasis in Vivo Am. J. Pathol., September 1, 2007; 171(3): 1047 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Watanabe, M. Shionyu, T. Kimura, K. Kimata, and H. Watanabe Splicing Factor 3b Subunit 4 Binds BMPR-IA and Inhibits Osteochondral Cell Differentiation J. Biol. Chem., July 13, 2007; 282(28): 20728 - 20738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hagen, K. Fagan, W. Steudel, M. Carr, K. Lane, D. M. Rodman, and J. West Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1473 - L1479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Tzachanis, L. Li, E. M. Lafuente, A. Berezovskaya, G. J. Freeman, and V. A. Boussiotis Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-{beta} signaling in activated T lymphocytes Blood, April 1, 2007; 109(7): 2944 - 2952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hiratochi, H. Nagase, Y. Kuramochi, C.-S. Koh, T. Ohkawara, and K. Nakayama The Delta intracellular domain mediates TGF-{beta}/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway Nucleic Acids Res., February 16, 2007; 35(3): 912 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Allen and T. G. Unterman Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors Am J Physiol Cell Physiol, January 1, 2007; 292(1): C188 - C199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. R. Jackman and D. W. Stock Transgenic analysis of Dlx regulation in fish tooth development reveals evolutionary retention of enhancer function despite organ loss PNAS, December 19, 2006; 103(51): 19390 - 19395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zhang, D. Fraser, and A. Phillips ERK, p38, and Smad Signaling Pathways Differentially Regulate Transforming Growth Factor-{beta}1 Autoinduction in Proximal Tubular Epithelial Cells Am. J. Pathol., October 1, 2006; 169(4): 1282 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ghosh-Choudhury, P. K. Singha, K. Woodruff, P. S. Clair, S. Bsoul, S. L. Werner, and G. G. Choudhury Concerted Action of Smad and CREB-binding Protein Regulates Bone Morphogenetic Protein-2-stimulated Osteoblastic Colony-stimulating Factor-1 Expression J. Biol. Chem., July 21, 2006; 281(29): 20160 - 20170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-T. Chou and Y.-C. Yang Post-transcriptional Control of Cited2 by Transforming Growth Factor beta: REGULATION VIA SMADS AND CITED2 CODING REGION J. Biol. Chem., July 7, 2006; 281(27): 18451 - 18462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Boxall, S. T. Holgate, and D. E. Davies The contribution of transforming growth factor-{beta} and epidermal growth factor signalling to airway remodelling in chronic asthma Eur. Respir. J., January 1, 2006; 27(1): 208 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.T. Franceschi Biological Approaches to Bone Regeneration by Gene Therapy J. Dent. Res., December 1, 2005; 84(12): 1093 - 1103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Jin, B.-C. Kim, C. Tognon, H.-J. Lee, S. Patel, C. L. Lannon, J. M. Maris, T. J. Triche, P. H. B. Sorensen, and S.-J. Kim The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-{beta} signaling by inactivating the TGF-{beta} type II receptor PNAS, November 8, 2005; 102(45): 16239 - 16244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Vallier, M. Alexander, and R. A. Pedersen Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells J. Cell Sci., October 1, 2005; 118(19): 4495 - 4509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Kim, H.-A. Kim, H.-S. Jong, J.-H. Park, N. K. Kim, S. H. Hong, T.-Y. Kim, and Y.-J. Bang The Endogenous Ratio of Smad2 and Smad3 Influences the Cytostatic Function of Smad3 Mol. Biol. Cell, October 1, 2005; 16(10): 4672 - 4683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Levy and C. S. Hill Smad4 Dependency Defines Two Classes of Transforming Growth Factor {beta} (TGF-{beta}) Target Genes and Distinguishes TGF-{beta}-Induced Epithelial-Mesenchymal Transition from Its Antiproliferative and Migratory Responses Mol. Cell. Biol., September 15, 2005; 25(18): 8108 - 8125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Collart, J. E. Remacle, S. Barabino, L. A. van Grunsven, L. Nelles, A. Schellens, T. Van de Putte, S. Pype, D. Huylebroeck, and K. Verschueren Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein Genes Cells, September 1, 2005; 10(9): 897 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hageman, B. J. Eggen, T. Rozema, K. Damman, H. H. Kampinga, and R. P. Coppes Radiation and Transforming Growth Factor-{beta} Cooperate in Transcriptional Activation of the Profibrotic Plasminogen Activator Inhibitor-1 Gene Clin. Cancer Res., August 15, 2005; 11(16): 5956 - 5964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F.J.D. Benus, A. T.J. Wierenga, D. J.J. de Gorter, J. J. Schuringa, A. M. van Bennekum, L. Drenth-Diephuis, E. Vellenga, and B. J.L. Eggen Inhibition of the Transforming Growth Factor {beta} (TGF{beta}) Pathway by Interleukin-1{beta} Is Mediated through TGF{beta}-activated Kinase 1 Phosphorylation of SMAD3 Mol. Biol. Cell, August 1, 2005; 16(8): 3501 - 3510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Suszko, D. M. Balkin, Y. Chen, and T. K. Woodruff Smad3 Mediates Activin-Induced Transcription of Follicle-Stimulating Hormone {beta}-Subunit Gene Mol. Endocrinol., July 1, 2005; 19(7): 1849 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Plisov, M. Tsang, G. Shi, S. Boyle, K. Yoshino, S. L. Dunwoodie, I. B. Dawid, T. Shioda, A. O. Perantoni, and M. P. de Caestecker Cited1 Is a Bifunctional Transcriptional Cofactor That Regulates Early Nephronic Patterning J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1632 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Faour, N. Alaaeddine, A. Mancini, Q. W. He, D. Jovanovic, and J. A. Di Battista Early Growth Response Factor-1 Mediates Prostaglandin E2-dependent Transcriptional Suppression of Cytokine-induced Tumor Necrosis Factor-{alpha} Gene Expression in Human Macrophages and Rheumatoid Arthritis-affected Synovial Fibroblasts J. Biol. Chem., March 11, 2005; 280(10): 9536 - 9546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Lee, J. L. Kang, and Y. H. Chong The Amyloid-{beta} Peptide Suppresses Transforming Growth Factor-{beta}1-induced Matrix Metalloproteinase-2 Production via Smad7 Expression in Human Monocytic THP-1 Cells J. Biol. Chem., March 4, 2005; 280(9): 7845 - 7853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lux, C. Beil, M. Majety, S. Barron, C. J. Gallione, H.-M. Kuhn, J. N. Berg, P. Kioschis, D. A. Marchuk, and M. Hafner Human Retroviral gag- and gag-pol-like Proteins Interact with the Transforming Growth Factor-{beta} Receptor Activin Receptor-like Kinase 1 J. Biol. Chem., March 4, 2005; 280(9): 8482 - 8493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nohe, E. Keating, T. M. Underhill, P. Knaus, and N. O. Petersen Dynamics and interaction of caveolin-1 isoforms with BMP-receptors J. Cell Sci., February 1, 2005; 118(3): 643 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sammar, S. Stricker, G. C. Schwabe, C. Sieber, A. Hartung, M. Hanke, I. Oishi, J. Pohl, Y. Minami, W. Sebald, et al. Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2 Genes Cells, December 1, 2004; 9(12): 1227 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.S. Prime, M. Pring, M. Davies, and I.C. Paterson TGF-{beta} SIGNAL TRANSDUCTION IN ORO-FACIAL HEALTH AND NON-MALIGNANT DISEASE (PART I) Crit. Rev. Oral. Biol. Med., November 1, 2004; 15(6): 324 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Y. Kim, D.-H. Lee, D. K. Lee, W. J. Kim, M. M. Kim, R. A. Morton, S. P. Lerner, and S. J. Kim Restoration of Bone Morphogenetic Protein Receptor Type II Expression Leads to a Decreased Rate of Tumor Growth in Bladder Transitional Cell Carcinoma Cell Line TSU-Pr1 Cancer Res., October 15, 2004; 64(20): 7355 - 7360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Brugger, A. E. Merrill, J. Torres-Vazquez, N. Wu, M.-C. Ting, J. Y.-M. Cho, S. L. Dobias, S. E. Yi, K. Lyons, J. R. Bell, et al. A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos Development, October 15, 2004; 131(20): 5153 - 5165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Peterson, R. A. Andhare, K. T. Rousche, W. Knudson, W. Wang, J. B. Grossfield, R. O. Thomas, R. E. Hollingsworth, and C. B. Knudson CD44 modulates Smad1 activation in the BMP-7 signaling pathway J. Cell Biol., September 27, 2004; 166(7): 1081 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Monteiro, S. M. C. de Sousa Lopes, O. Korchynskyi, P. t. Dijke, and C. L. Mummery Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins J. Cell Sci., September 15, 2004; 117(20): 4653 - 4663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Abecassis, E. Rogier, A. Vazquez, A. Atfi, and M.-F. Bourgeade Evidence for a Role of MSK1 in Transforming Growth Factor-{beta}-mediated Responses through p38{alpha} and Smad Signaling Pathways J. Biol. Chem., July 16, 2004; 279(29): 30474 - 30479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Waddell, N. T. Liberati, X. Guo, J. P. Frederick, and X.-F. Wang Casein Kinase I{epsilon} Plays a Functional Role in the Transforming Growth Factor-{beta} Signaling Pathway J. Biol. Chem., July 9, 2004; 279(28): 29236 - 29246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Colland, X. Jacq, V. Trouplin, C. Mougin, C. Groizeleau, A. Hamburger, A. Meil, J. Wojcik, P. Legrain, and J.-M. Gauthier Functional Proteomics Mapping of a Human Signaling Pathway Genome Res., July 1, 2004; 14(7): 1324 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Selvamurugan, S. Kwok, and N. C. Partridge Smad3 Interacts with JunB and Cbfa1/Runx2 for Transforming Growth Factor-{beta}1-stimulated Collagenase-3 Expression in Human Breast Cancer Cells J. Biol. Chem., June 25, 2004; 279(26): 27764 - 27773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sudo, O. Avsian-Kretchmer, L. S. Wang, and A. J. W. Hsueh Protein Related to DAN and Cerberus Is a Bone Morphogenetic Protein Antagonist That Participates in Ovarian Paracrine Regulation J. Biol. Chem., May 28, 2004; 279(22): 23134 - 23141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. West, K. Fagan, W. Steudel, B. Fouty, K. Lane, J. Harral, M. Hoedt-Miller, Y. Tada, J. Ozimek, R. Tuder, et al. Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle Circ. Res., April 30, 2004; 94(8): 1109 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. McKarns, R. H. Schwartz, and N. E. Kaminski Smad3 Is Essential for TGF-{beta}1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation J. Immunol., April 1, 2004; 172(7): 4275 - 4284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. O. Brown III, X. Chi, E. Garcia-Gras, M. Shirai, X.-H. Feng, and R. J. Schwartz The Cardiac Determination Factor, Nkx2-5, Is Activated by Mutual Cofactors GATA-4 and Smad1/4 via a Novel Upstream Enhancer J. Biol. Chem., March 12, 2004; 279(11): 10659 - 10669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Aurrekoetxea-Hernandez and E. Buetti Transforming Growth Factor {beta} Enhances the Glucocorticoid Response of the Mouse Mammary Tumor Virus Promoter through Smad and GA-Binding Proteins J. Virol., March 1, 2004; 78(5): 2201 - 2211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Oka, R. Tsujimoto, M. Kajikawa, K. Koshiba-Takeuchi, J. Ina, M. Yano, A. Tsuchiya, Y. Ueta, A. Soma, H. Kanda, et al. HtrA1 serine protease inhibits signaling mediated by Tgf{beta} family proteins Development, March 1, 2004; 131(5): 1041 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Hussein, E. K. Duff, and C. Sirard Smad4 and {beta}-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2 J. Biol. Chem., December 5, 2003; 278(49): 48805 - 48814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Lai, S. C. W. Tang, J.-Y. Guh, T.-D. Chuang, M. F. Lam, L. Y. Y. Chan, A. W. L. Tsang, and J. C. K. Leung Polymeric IgA1 from Patients with IgA Nephropathy Upregulates Transforming Growth Factor-{beta} Synthesis and Signal Transduction in Human Mesangial Cells via the Renin-Angiotensin System J. Am. Soc. Nephrol., December 1, 2003; 14(12): 3127 - 3137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Y. Kim, D.-H. Lee, D. K. Lee, B. C. Kim, H. T. Kim, F. S. Leach, W. M. Linehan, R. A. Morton, and S. J. Kim Decreased Expression of Bone Morphogenetic Protein (BMP) Receptor Type II Correlates with Insensitivity to BMP-6 in Human Renal Cell Carcinoma Cells Clin. Cancer Res., December 1, 2003; 9(16): 6046 - 6051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Dowdy, A. Mariani, and R. Janknecht HER2/Neu- and TAK1-mediated Up-regulation of the Transforming Growth Factor {beta} Inhibitor Smad7 via the ETS Protein ER81 J. Biol. Chem., November 7, 2003; 278(45): 44377 - 44384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu, R. Santora, J. N. Rao, X. Guo, T. Zou, H. M. Zhang, D. J. Turner, and J.-Y. Wang Activation of TGF-{beta}-Smad signaling pathway following polyamine depletion in intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, November 1, 2003; 285(5): G1056 - G1067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takahashi, T. Shintani, H. Sakuta, and M. Noda CBF1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms Development, November 1, 2003; 130(21): 5203 - 5215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Song, S. C. Cornelius, M. Reiss, and D. Danielpour Insulin-like Growth Factor-I Inhibits Transcriptional Responses of Transforming Growth Factor-{beta} by Phosphatidylinositol 3-Kinase/Akt-dependent Suppression of the Activation of Smad3 but Not Smad2 J. Biol. Chem., October 3, 2003; 278(40): 38342 - 38351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Mellor, E. M. A. Ball, A. E. O'Connor, J.-F. Ethier, M. Cranfield, J. F. Schmitt, D. J. Phillips, N. P. Groome, and G. P. Risbridger Activin {beta}C-Subunit Heterodimers Provide a New Mechanism of Regulating Activin Levels in the Prostate Endocrinology, October 1, 2003; 144(10): 4410 - 4419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
