| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 34, 21451-21454, August 21, 1998
-Aminobutyric Acid
(GABA) Release
From the Center for Basic Neuroscience, Department of Molecular
Genetics and Howard Hughes Medical Institute, The University of Texas
Southwestern Medical Center, Dallas, Texas 75235
Newly synthesized phosphatidylinositol phosphates
have been implicated in many membrane-trafficking reactions. They are
essential for exocytosis of norepinephrine in PC12 cells and chromaffin cells, suggesting a function in membrane fusion. We have now studied the role of phosphatidylinositol phosphates in synaptic vesicle exocytosis using synaptosomes. Under conditions where phosphorylation of phosphatidylinositols is blocked, norepinephrine secretion was
nearly abolished whereas glutamate and GABA release was still elicited.
Thus phosphatidylinositides are essential only for some membrane fusion
reactions, and exocytotic release mechanisms differ between
neurotransmitters.
This article has been cited by other articles:
|
|
 |
|
  A. C. Ashton and Y. A. Ushkaryov Properties of Synaptic Vesicle Pools in Mature Central Nerve Terminals J. Biol. Chem., November 4, 2005; 280(44): 37278 - 37288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chandra, F. Fornai, H.-B. Kwon, U. Yazdani, D. Atasoy, X. Liu, R. E. Hammer, G. Battaglia, D. C. German, P. E. Castillo, et al. Double-knockout mice for {alpha}- and {beta}-synucleins: Effect on synaptic functions PNAS, October 12, 2004; 101(41): 14966 - 14971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rajebhosale, S. Greenwood, J. Vidugiriene, A. Jeromin, and S. Hilfiker Phosphatidylinositol 4-OH Kinase Is a Downstream Target of Neuronal Calcium Sensor-1 in Enhancing Exocytosis in Neuroendocrine Cells J. Biol. Chem., February 14, 2003; 278(8): 6075 - 6084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. HOLZ and D. AXELROD Localization of Phosphatidylinositol 4,5-P2 Important in Exocytosis and a Quantitative Analysis of Chromaffin Granule Motion Adjacent to the Plasma Membrane Ann. N.Y. Acad. Sci., October 1, 2002; 971(1): 232 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Gerber and T. C. Sudhof Molecular Determinants of Regulated Exocytosis Diabetes, February 1, 2002; 51(90001): S3 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O Cremona and P De Camilli Phosphoinositides in membrane traffic at the synapse J. Cell Sci., January 3, 2001; 114(6): 1041 - 1052. [Abstract] [PDF]
|
|
|
|
 |
|
 S. D. Sorensen, D. A. Linseman, E. L. McEwen, A. M. Heacock, and S. K. Fisher Inhibition of beta 2-Adrenergic and Muscarinic Cholinergic Receptor Endocytosis after Depletion of Phosphatidylinositol Bisphosphate J. Pharmacol. Exp. Ther., August 1, 1999; 290(2): 603 - 610. [Abstract] [Full Text]
|
|
|
|
|
|
S. Sugita, K. Ichtchenko, M. Khvotchev, and T. C. Sudhof alpha -Latrotoxin Receptor CIRL/Latrophilin 1 (CL1) Defines an Unusual Family of Ubiquitous G-protein-linked Receptors. G-PROTEIN COUPLING NOT REQUIRED FOR TRIGGERING EXOCYTOSIS J. Biol. Chem., December 4, 1998; 273(49): 32715 - 32724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Holz, M. D. Hlubek, S. D. Sorensen, S. K. Fisher, T. Balla, S. Ozaki, G. D. Prestwich, E. L. Stuenkel, and M. A. Bittner A Pleckstrin Homology Domain Specific for Phosphatidylinositol 4,5-Bisphosphate (PtdIns-4,5-P2) and Fused to Green Fluorescent Protein Identifies Plasma Membrane PtdIns-4,5-P2 as Being Important in Exocytosis J. Biol. Chem., June 2, 2000; 275(23): 17878 - 17885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Ashton, K. E. Volynski, V. G. Lelianova, E. V. Orlova, C. Van Renterghem, M. Canepari, M. Seagar, and Y. A. Ushkaryov alpha -Latrotoxin, Acting via Two Ca2+-dependent Pathways, Triggers Exocytosis of Two Pools of Synaptic Vesicles J. Biol. Chem., November 21, 2001; 276(48): 44695 - 44703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Bruns, M. A. Ellis, A. Jeromin, and O. A. Weisz Multiple Roles for Phosphatidylinositol 4-Kinase in Biosynthetic Transport in Polarized Madin-Darby Canine Kidney Cells J. Biol. Chem., January 11, 2002; 277(3): 2012 - 2018. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
