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J Biol Chem, Vol. 273, Issue 34, 21777-21782, August 21, 1998

Cell Signaling by the Type IV Pili of Pathogenic Neisseria

Helena KällströmDagger , Md. Shahidul Islam, Per-Olof Berggren, and Ann-Beth JonssonDagger

From the Dagger  Microbiology and Tumorbiology Center, Karolinska Institute, S-171 77, Stockholm, Sweden and  The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institute, Karolinska Hospital, S-171 76 Stockholm, Sweden

Neisseria gonorrhoeae and Neisseria meningitidis are Gram-negative bacterial pathogens that infect human mucosal epithelia. Type IV pilus-mediated adherence of these bacteria is a crucial early event for establishment of infection. In this work, we show that the type IV pili transduce a signal into the eucaryotic host cell. Purified adherent pili, but not pili from a low binding mutant, trigger an increase in the cytosolic free calcium ([Ca2+]i) in target epithelial cells, a signal known to control many cellular responses. The [Ca2+]i increase was blocked by antibodies against CD46, a putative pilus receptor, suggesting a role for this protein in signal transduction. Pilus-mediated attachment was inhibited by depletion of host cell intracellular Ca2+ stores but not by removal of extracellular Ca2+. Further, kinase inhibition studies showed that pilus-mediated adherence is dependent on casein kinase II. In summary, these data reveal a novel function of the type IV pili, namely induction of signal transduction pathways in host cells.

Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.


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