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J Biol Chem, Vol. 273, Issue 35, 22395-22401, August 28, 1998
From the Departments of Two complementary DNAs for the organic anion
transporter subtypes oatp2 and oatp3, which transport thyroid hormones
as well as taurocholate, were isolated from a rat retina cDNA
library. The sequence of oatp2 is identical to that recently reported
(Noé, B., Hagenbuch, B., Stieger, B., and Meier, P. J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10346-10350),
whereas the sequence of oatp3 is novel. oatp3 consists of 670 amino
acid residues and exhibits a structural architecture common to the
organic anion transporter family, possessing the 12 putative
membrane-spanning segments. Oocytes injected with oatp2 and oatp3 cRNAs
showed taurocholate uptake in a saturable manner. The oatp2 and oatp3
cRNA-injected oocytes also showed significant uptake of both thyroxine
and triiodothyronine. Northern blot and in situ analyses
showed that the oatp2 mRNA was widely expressed in neuronal cells
of the central nervous system, especially in the hippocampus,
cerebellum, and choroid plexus as well as in the retina and liver. The
oatp3 mRNA was highly expressed in the kidney and moderately
abundant in the retina. This suggests that oatp2 and oatp3 are
multifunctional transporters involved in the transport of thyroid
hormones in the brain, retina, liver, and kidney.
Molecular Characterization and Tissue Distribution of a New
Organic Anion Transporter Subtype (oatp3) That Transports Thyroid
Hormones and Taurocholate and Comparison with oatp2
,¶,
,,,,,, and
Neurophysiology and
Histology and the ¶ First Department of Surgery, Tohoku
University School of Medicine, Sendai 980-8575, Japan, ** Analytical and
Metabolic Research Laboratories, Sankyo Company, Limited, Tokyo
140-8710, Japan, and the Divison of
Nephrology, Vanderbilt University,
Nashville, Tennessee, 37232-2372
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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S. Akhteruzzaman, Y. Kato, H. Kouzuki, H. Suzuki, A. Hisaka, B. Stieger, P. J. Meier, and Y. Sugiyama Carrier-Mediated Hepatic Uptake of Peptidic Endothelin Antagonists in Rats J. Pharmacol. Exp. Ther., September 1, 1999; 290(3): 1107 - 1115. [Abstract] [Full Text]
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T. Cihlar, D. C. Lin, J. B. Pritchard, M. D. Fuller, D. B. Mendel, and D. H. Sweet The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter 1 Mol. Pharmacol., September 1, 1999; 56(3): 570 - 580. [Abstract] [Full Text]
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 N. Strazielle and J.-F. Ghersi-Egea Demonstration of a Coupled Metabolism-Efflux Process at the Choroid Plexus as a Mechanism of Brain Protection Toward Xenobiotics J. Neurosci., August 1, 1999; 19(15): 6275 - 6289. [Abstract] [Full Text] [PDF]
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J.-i. Nishino, H. Suzuki, D. Sugiyama, T. Kitazawa, K. Ito, M. Hanano, and Y. Sugiyama Transepithelial Transport of Organic Anions across the Choroid Plexus: Possible Involvement of Organic Anion Transporter and Multidrug Resistance-Associated Protein J. Pharmacol. Exp. Ther., July 1, 1999; 290(1): 289 - 294. [Abstract] [Full Text]
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T. Abe, M. Kakyo, T. Tokui, R. Nakagomi, T. Nishio, D. Nakai, H. Nomura, M. Unno, M. Suzuki, T. Naitoh, et al. Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1 J. Biol. Chem., June 11, 1999; 274(24): 17159 - 17163. [Abstract] [Full Text] [PDF]
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 G. A. Brent Thyroid hormone action: down novel paths Focus on "Thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells" Am J Physiol Cell Physiol, May 1, 1999; 276(5): C1012 - C1013. [Full Text] [PDF]
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U. Eckhardt, A. Schroeder, B. Stieger, M. Hochli, L. Landmann, R. Tynes, P. J. Meier, and B. Hagenbuch Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells Am J Physiol Gastrointest Liver Physiol, April 1, 1999; 276(4): G1037 - G1042. [Abstract] [Full Text] [PDF]
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S. Masuda, K. Ibaramoto, A. Takeuchi, H. Saito, Y. Hashimoto, and K.-I. Inui Cloning and Functional Characterization of a New Multispecific Organic Anion Transporter, OAT-K2, in Rat Kidney Mol. Pharmacol., April 1, 1999; 55(4): 743 - 752. [Abstract] [Full Text]
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J. Konig, Y. Cui, A. T. Nies, and D. Keppler Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide J. Biol. Chem., July 21, 2000; 275(30): 23161 - 23168. [Abstract] [Full Text] [PDF]
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 H. Kawaji, C. Schonbach, Y. Matsuo, J. Kawai, Y. Okazaki, Y. Hayashizaki, and H. Matsuda Exploration of Novel Motifs Derived from Mouse cDNA Sequences Genome Res., March 1, 2002; 12(3): 367 - 378. [Abstract] [Full Text] [PDF]
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