| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 36, 23183-23190, September 4, 1998
B in the Antiproliferative Effect of Endothelin-1
and Tumor Necrosis Factor-
in Human Hepatic Stellate Cells
,,
From the Unité INSERM 99, During chronic liver diseases, hepatic stellate
cells (HSC) acquire an activated myofibroblast-like phenotype and
proliferate and synthesize fibrosis components. Endothelin-1 (ET-1),
which inhibited the growth of human myofibroblastic HSC, increased the formation of two NF- Unité INSERM 348,
B DNA binding complexes; this effect was also
observed with tumor necrosis factor-
(TNF-). The complexes were
identified as the p50/p50 and p50/p65 NF-B dimers. Activation of
NF-B was associated with the degradation of the inhibitory protein
IB-; no IB-
was detected. Activation of NF-B and degradation of IB- were prevented by the NF-B inhibitors
sodium salicylate and MG-132. In addition to cyclooxygenase-1 (COX-1), COX-2 is also constitutively expressed in human HSC, and the use of
dexamethasone and of SC-58125, a selective COX-2 inhibitor, revealed
that COX-2 accounts for basal COX activity. Moreover, COX-2
mRNA and protein were up-regulated by ET-1 and TNF-, whereas COX-1 was unaffected. Induction of COX-2 and stimulation of
COX activity by ET-1 and TNF- were prevented by sodium salicylate and MG-132, suggesting that activation of NF-B by either factor is
needed for stimulation of COX-2. Finally, SC-58125 and
dexamethasone reduced the growth inhibitory effect of ET-1 and TNF-,
indicating that activation of COX-2 is required for inhibition of HSC
proliferation. Taken together, our results suggest that NF-B, by
inducing COX-2 expression, may play an important role in
the negative regulation of human myofibroblastic HSC proliferation.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
This article has been cited by other articles:
|
|
 |
|
  J. S. Swaney, D. M. Roth, E. R. Olson, J. E. Naugle, J. G. Meszaros, and P. A. Insel Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase PNAS, January 11, 2005; 102(2): 437 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kumagai, N. Matsukawa, Y. Kaneko, Y. Kusumi, M. Mitsumata, and K. Uchida A Lipid Peroxidation-derived Inflammatory Mediator: IDENTIFICATION OF 4-HYDROXY-2-NONENAL AS A POTENTIAL INDUCER OF CYCLOOXYGENASE-2 IN MACROPHAGES J. Biol. Chem., November 12, 2004; 279(46): 48389 - 48396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zhang, Z.-N. Lin, C.-F. Yang, X. Shi, C.-N. Ong, and H.-M. Shen Suppressed NF-{kappa}B and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-{alpha}-induced apoptosis in human cancer cells Carcinogenesis, November 1, 2004; 25(11): 2191 - 2199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. F. Yang, R. T. Poon, J. To, D. W. Ho, and S. T. Fan The Potential Role of Hypoxia Inducible Factor 1{alpha} in Tumor Progression after Hypoxia and Chemotherapy in Hepatocellular Carcinoma Cancer Res., August 1, 2004; 64(15): 5496 - 5503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tanaka, T. Sato, H. Fujita, and I. Morita Constitutive Expression and Involvement of Cyclooxygenase-2 in Human Megakaryocytopoiesis Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 607 - 612. [Abstract] [Full Text]
|
|
|
|
|
|
V. T. Todorov, S. Volkl, M. Muller, A. Bohla, J. Klar, L. A. Kunz-Schughart, T. Hehlgans, and A. Kurtz Tumor Necrosis Factor-{alpha} Activates NF{kappa}B to Inhibit Renin Transcription by Targeting cAMP-responsive Element J. Biol. Chem., January 9, 2004; 279(2): 1458 - 1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Liu, R. T. Premont, C. D. Kontos, J. Huang, and D. C. Rockey Endothelin-1 Activates Endothelial Cell Nitric-oxide Synthase via Heterotrimeric G-protein {beta}{gamma} Subunit Signaling to Protein Kinase B/Akt J. Biol. Chem., December 12, 2003; 278(50): 49929 - 49935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fujita, J. M. Shannon, O. Morikawa, J. Gauldie, N. Hara, and R. J. Mason Overexpression of Tumor Necrosis Factor-{alpha} Diminishes Pulmonary Fibrosis Induced by Bleomycin or Transforming Growth Factor-{beta} Am. J. Respir. Cell Mol. Biol., December 1, 2003; 29(6): 669 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chen, Z. A. Khan, M. Cukiernik, and S. Chakrabarti Differential activation of NF-kappa B and AP-1 in increased fibronectin synthesis in target organs of diabetic complications Am J Physiol Endocrinol Metab, June 1, 2003; 284(6): E1089 - E1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Spoel, A. Koornneef, S. M. C. Claessens, J. P. Korzelius, J. A. Van Pelt, M. J. Mueller, A. J. Buchala, J.-P. Metraux, R. Brown, K. Kazan, et al. NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol PLANT CELL, March 1, 2003; 15(3): 760 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chen, S. Mukherjee, C. Chakraborty, and S. Chakrabarti High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1 Am J Physiol Cell Physiol, February 1, 2003; 284(2): C263 - C272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Davaille, L. Li, A. Mallat, and S. Lotersztajn Sphingosine 1-Phosphate Triggers Both Apoptotic and Survival Signals for Human Hepatic Myofibroblasts J. Biol. Chem., September 27, 2002; 277(40): 37323 - 37330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Han and T. J. Smith Cytoplasmic Prostaglandin E2 Synthase Is Dominantly Expressed in Cultured KAT-50 Thyrocytes, Cells That Express Constitutive Prostaglandin-endoperoxide H Synthase-2. BASIS FOR LOW PROSTAGLANDIN E2 PRODUCTION J. Biol. Chem., September 20, 2002; 277(39): 36897 - 36903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D A Mann and D E Smart Transcriptional regulation of hepatic stellate cell activation Gut, June 1, 2002; 50(6): 891 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Denda, W. Kitayama, A. Murata, H. Kishida, Y. Sasaki, O. Kusuoka, T. Tsujiuchi, M. Tsutsumi, D. Nakae, H. Takagi, et al. Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide Carcinogenesis, February 1, 2002; 23(2): 245 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Ye Regulation of nuclear factor {kappa}B activation by G-protein-coupled receptors J. Leukoc. Biol., December 1, 2001; 70(6): 839 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kanamaru, H. Yasuda, M. Takeda, N. Ueda, J. Suzuki, T. Tsuchida, H. Mashima, H. Ohnishi, and T. Fujita Smad7 Is Induced by Norepinephrine and Protects Rat Hepatocytes from Activin A-induced Growth Inhibition J. Biol. Chem., November 30, 2001; 276(49): 45636 - 45641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Gianoukakis, H. J. Cao, T. A. Jennings, and T. J. Smith Prostaglandin endoperoxide H synthase expression in human thyroid epithelial cells Am J Physiol Cell Physiol, March 1, 2001; 280(3): C701 - C708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Laporte, P. E. Moore, T. Lahiri, I. N. Schwartzman, R. A. Panettieri Jr., and S. A. Shore p38 MAP kinase regulates IL-1beta responses in cultured airway smooth muscle cells Am J Physiol Lung Cell Mol Physiol, November 1, 2000; 279(5): L932 - L941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Ye beta -Adrenergic agonists regulate NF-kappa B activation through multiple mechanisms Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L615 - L617. [Full Text] [PDF]
|
|
|
|
 |
|
 C.-C. Chen, Y.-T. Sun, J.-J. Chen, and K.-T. Chiu TNF-{alpha}-Induced Cyclooxygenase-2 Expression in Human Lung Epithelial Cells: Involvement of the Phospholipase C-{gamma}2, Protein Kinase C-{alpha}, Tyrosine Kinase, NF-{kappa}B-Inducing Kinase, and I-{kappa}B Kinase 1/2 Pathway J. Immunol., September 1, 2000; 165(5): 2719 - 2728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Levy, S.-i. Kobayashi, Z. Roth, D. Wolfenson, A. Miyamoto, and R. Meidan Administration of Prostaglandin F2{alpha} During the Early Bovine Luteal Phase Does Not Alter the Expression of ET-1 and of Its Type A Receptor: A Possible Cause for Corpus Luteum Refractoriness Biol Reprod, August 1, 2000; 63(2): 377 - 382. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. J. Eng and S. L. Friedman Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G7 - G11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Abraham, X. Shiwen, C. M. Black, S. Sa, Y. Xu, and A. Leask Tumor Necrosis Factor alpha Suppresses the Induction of Connective Tissue Growth Factor by Transforming Growth Factor-beta in Normal and Scleroderma Fibroblasts J. Biol. Chem., May 12, 2000; 275(20): 15220 - 15225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. GALLOIS, J. DAVAILLE, A. HABIB, A. MALLAT, J. TAO, T. LEVADE, and S. LOTOERSZTAJN Endothelin-1 Stimulates Sphingosine Kinase in Human Hepatic Stellate Cells: A Novel Role for Sphingosine-1-P as a Mediator of Growth Inhibition Ann. N.Y. Acad. Sci., April 1, 2000; 905(1): 311 - 314. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alonso, Y. Bayon, M. Renedo, and M. S. Crespo Stimulation of Fc{gamma}R receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving I{kappa}B-{alpha} degradation and formation of p50/p65 NF-{kappa}B/Rel complexes Int. Immunol., April 1, 2000; 12(4): 547 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nagase, H. Kurihara, Y. Kurihara, T. Aoki-Nagase, R. Nagai, and Y. Ouchi Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout mice J Appl Physiol, December 1, 1999; 87(6): 2020 - 2024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.L. Slomiany, J. Piotrowski, and A. Slomiany Effect of ebrotidine on Helicobacter pylori lipopolysaccharide-induced up-regulation of endothelin-1 in gastric mucosa Innate Immunity, October 1, 1999; 5(5-6): 279 - 285. [Abstract] [PDF]
|
|
|
|
|
|
J. Tao, A. Mallat, C. Gallois, S. Belmadani, P.-F. Mery, J. T.-V. Nhieu, C. Pavoine, and S. Lotersztajn Biological Effects of C-type Natriuretic Peptide in Human Myofibroblastic Hepatic Stellate Cells J. Biol. Chem., August 20, 1999; 274(34): 23761 - 23769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Smith, T. A. Jennings, D. Sciaky, and H. J. Cao Prostaglandin-endoperoxide H Synthase-2 Expression in Human Thyroid Epithelium. EVIDENCE FOR CONSTITUTIVE EXPRESSION IN VIVO AND IN CULTURED KAT-50 CELLS J. Biol. Chem., May 28, 1999; 274(22): 15622 - 15632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Xie, D. D. Browning, N. Hay, N. Mackman, and R. D. Ye Activation of NF-kappa B by Bradykinin through a Galpha q- and Gbeta gamma -dependent Pathway That Involves Phosphoinositide 3-Kinase and Akt J. Biol. Chem., August 4, 2000; 275(32): 24907 - 24914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Davaille, C. Gallois, A. Habib, L. Li, A. Mallat, J. Tao, T. Levade, and S. Lotersztajn Antiproliferative Properties of Sphingosine 1-Phosphate in Human Hepatic Myofibroblasts. A CYCLOOXYGENASE-2 MEDIATED PATHWAY J. Biol. Chem., October 27, 2000; 275(44): 34628 - 34633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-S. Shi and J. H. Kehrl PYK2 Links Gqalpha and G13alpha Signaling to NF-kappa B Activation J. Biol. Chem., August 17, 2001; 276(34): 31845 - 31850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li, J. Tao, J. Davaille, C. Feral, A. Mallat, J. Rieusset, H. Vidal, and S. Lotersztajn 15-Deoxy-Delta 12,14-prostaglandin J2 Induces Apoptosis of Human Hepatic Myofibroblasts. A PATHWAY INVOLVING OXIDATIVE STRESS INDEPENDENTLY OF PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTORS J. Biol. Chem., October 5, 2001; 276(41): 38152 - 38158. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
