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J Biol Chem, Vol. 273, Issue 36, 23367-23375, September 4, 1998
From the Department of Pathology, Tufts University School of
Medicine, Boston, Massachusetts 02111
CD48 is a member of the immunoglobulin
superfamily whose cell surface expression is strikingly up-regulated on
the surface of Epstein-Barr virus-infected B cells. To date, no ligand
for human CD48 has been characterized. In this study, we show that human recombinant CD48 binds to the glycosaminoglycan heparan sulfate
on the surface of human epithelial cells. We have produced a monoclonal
antibody (615) against epithelial cell surfaces that blocks this
binding and show that it too recognizes heparan sulfate. The specific
epitope on heparan sulfate that is recognized by the antibody and is
involved in binding is also expressed in vivo on the
basolateral surfaces of mucosal epithelium and lamina propria.
CD48 Binds to Heparan Sulfate on the Surface of Epithelial
Cells
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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