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J Biol Chem, Vol. 273, Issue 37, 23641-23644, September 11, 1998
,
From the The yeast SWI/SNF chromatin remodeling complex is
comprised of 11 tightly associated polypeptides (SWI1, SWI2, SWI3,
SNF5, SNF6, SNF11, SWP82, SWP73, SWP59, SWP61, and SWP29). We have used matrix-assisted laser desorption ionization time-of-flight mass spectrometry to identify the genes that encode the SWP59 and SWP61 subunits. Surprisingly, we find that SWP59 and SWP61 are encoded by the
ARP9 and ARP7 genes, respectively, which encode
members of the actin-related protein (ARP) family. Sequence analyses
have shown that ARP9 and ARP7 are 24-26% identical (48-51% similar) to yeast actin and that they are likely to maintain the overall actin
fold. Deletion of either the ARP9 or ARP7 gene
causes typical swi/snf phenotypes, including growth defects
on media containing galactose, glycerol, or sucrose as sole carbon
sources. ARP9 and ARP7 are also required for
expression of an HO-lacZ fusion gene and for full
transcriptional enhancement by the GAL4 activator. The identification
of two ARP family members as crucial subunits of the SWI/SNF complex
suggests that the complex may contain a total of three different ATPase
subunits; furthermore, the similarity of ARP7 and ARP9 to the HSP and
HSC family of ATPases suggests the possibility that chromatin
remodeling by SWI/SNF may involve chaperone-like activities.
Program in Molecular Medicine and Department
of Biochemistry and Molecular Biology, University of Massachusetts
Medical Center, Worcester, Massachusetts 01605 and the
¶ Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The
Rockefeller University, New York, New York 10021
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