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J Biol Chem, Vol. 273, Issue 37, 23649-23651, September 11, 1998
2
in Vivo Ameliorates Streptozotocin-induced Diabetes
From the Departments of Molecular Pharmacology and of Physiology
and Biophysics, Diabetes and Metabolic Diseases Research Program,
University Medical Center, SUNY/Stony Brook,
Stony Brook, New York 11794-8651
Streptozotocin treatment in vivo
generates a model of insulin-dependent diabetes mellitus
via destruction of the pancreatic 
-cells responsible for insulin
secretion. Tissue-specific expression of the Q205L constitutively
activated mutant form of the G-protein Gi
2 in
vivo ameliorates streptozotocin-induced
insulin-dependent diabetes mellitus in transgenic mice.
Conditional expression of Q205L Gi2 in vivo
in liver, skeletal muscle, and adipose tissue markedly rectifies
glucose tolerance, fasting glucose levels, and glycogen synthase
activation in the mice with insulin-dependent diabetes
mellitus, providing a novel therapeutic target for diabetes.
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