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J Biol Chem, Vol. 273, Issue 37, 23698-23703, September 11, 1998
,
From the The Lewis X epitope,
Gal Departments of Psychiatry and Anatomy/Cell
Biology and the Psychiatric Institute, University of Illinois, Chicago,
llinois 60612 and ¶ Department of Biochemistry, Imperial College
of Science, Technology and Medicine,
London SW7 2AY United Kingdom
1-4(Fuc
1-3)GlcNAc-R, has been implicated in cell-cell
recognition events in a number of systems including the central nervous
system and is expressed on diverse glycoconjugates including cell
adhesion molecules, glycolipids, and the proteoglycan phosphacan.
Although Lewis X sequences 3-linked to mannose have been
described within proteoglycan fractions of mammalian brain, these have
not been reported in other contexts and have been widely believed to be
peculiar constituents of brain proteoglycans. In the present paper, we
confirm the existence of Lewis X structures
O-linked to mannose within the mammalian brain, demonstrate
that these structures are present on a well defined mucin-like
glycoprotein, cranin (dystroglycan), and report studies suggesting that
the linkages involved may be predominantly 2-linked to mannose.
Mannose-linked Lewis X is the latest in an increasing list
of oligosaccharide recognition "tags" that have been shown to be
expressed on cranin (dystroglycan) purified from brain.
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