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J Biol Chem, Vol. 273, Issue 37, 23929-23937, September 11, 1998
From the The mesangial cell provides structural support to
the kidney glomerulus. A polymerase chain reaction-based cDNA
display approach identified a novel protein-tyrosine phosphatase,
rPTP-GMC1, whose transcript expression is transiently and dramatically
up-regulated during the period of mesangial cell migration and
proliferation that follows mesangial cell injury in the anti-Thy 1 model of mesangial proliferative glomerulonephritis in the rat.
In situ hybridization analysis confirmed that rPTP-GMC1
mRNA is up-regulated specifically by mesangial cells responding to
the injury and is not detectable in other cells in the kidney or
in many normal tissues. In cell culture, rPTP-GMC1 is expressed by
mesangial cells but not by glomerular endothelial or epithelial cells
(podocytes). The longest transcript (7.5 kilobases) encodes a
receptor-like protein-tyrosine phosphatase consisting of a single
catalytic domain, a transmembrane segment, and 18 fibronectin type
III-like repeats in the extracellular segment. A splice variant
predicts a truncated molecule missing the catalytic domain. rPTP-GMC1
maps to human chromosome 12q15 and to the distal end of mouse
chromosome 10. The predicted structure of rPTP-GMC1 and its pattern of
expression in vivo and in culture suggest that it plays a
role in regulating the adhesion and migration of mesangial cells in
response to injury.
Proliferating and Migrating Mesangial Cells Responding to Injury
Express a Novel Receptor Protein-tyrosine Phosphatase in Experimental
Mesangial Proliferative Glomerulonephritis
,,, and
Department of Pathology and the
¶ Division of Nephrology, University of Washington,
Seattle, Washington 98105-7470
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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