|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 38, 24932-24938, September 18, 1998
From the JE is a member of the family of
"immediate early" genes induced by growth factors and cytokines.
JE encodes a low molecular weight secretory glycoprotein
analogous to the human monocyte chemoattractant protein, MCP-1. JE and
MCP-1 proteins are thought to play an important role in inflammation
and in the recruitment of monocyte/macrophages to the vessel wall
during the development of atherosclerosis. We have previously reported
that the induction of JE in rat aortic smooth muscle cells
(SMC) was specific to platelet-derived growth factor (PDGF) and was not
seen with other growth agonists. Using a luciferase reporter system and
transient transfection assays of rat aortic SMC, we now report the
identification of a region in the proximal rat JE promoter
that is responsive to PDGF but not to other growth factors (angiotensin
II and
Platelet-derived Growth Factor-specific Regulation of the
JE Promoter in Rat Aortic Smooth Muscle Cells
§,, and
Cardiovascular Institute and Department of
Medicine and the § Brookdale Center for Molecular
Biology, Mount Sinai School of Medicine,
New York, New York 10029
-thrombin) or cytokines (interleukin 1-
and tumor necrosis
factor-). The full response to PDGF (~6-fold) requires the
cooperative activity of two potentially novel cis-acting
elements, at positions 
146 to 128 and 84 to 59. While each
element produces a different pattern in electrophoretic mobility shift
assays, they appear to bind the same PDGF-responsive species. Further
analysis of these regions should provide important insights into
PDGF-specific responses in vascular SMC.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. A. Reddy, S. Sahar, L. M. Villeneuve, L. Lanting, and R. Natarajan Role of Src Tyrosine Kinase in the Atherogenic Effects of the 12/15-Lipoxygenase Pathway in Vascular Smooth Muscle Cells Arterioscler. Thromb. Vasc. Biol., March 1, 2009; 29(3): 387 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tanimoto, Y. Murata, K.-Y. Wang, M. Tsutsui, K. Kohno, and Y. Sasaguri Monocyte Chemoattractant Protein-1 Expression Is Enhanced by Granulocyte-Macrophage Colony-stimulating Factor via Jak2-Stat5 Signaling and Inhibited by Atorvastatin in Human Monocytic U937 Cells J. Biol. Chem., February 22, 2008; 283(8): 4643 - 4651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Bromann, H. Korkaya, C. P. Webb, J. Miller, T. L. Calvin, and S. A. Courtneidge Platelet-derived Growth Factor Stimulates Src-dependent mRNA Stabilization of Specific Early Genes in Fibroblasts J. Biol. Chem., March 18, 2005; 280(11): 10253 - 10263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lassila, T. J. Allen, Z. Cao, V. Thallas, K. A. Jandeleit-Dahm, R. Candido, and M. E. Cooper Imatinib Attenuates Diabetes-Associated Atherosclerosis Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 935 - 942. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Zhan, S. Kim, Y. Izumi, Y. Izumiya, T. Nakao, H. Miyazaki, and H. Iwao Role of JNK, p38, and ERK in Platelet-Derived Growth Factor-Induced Vascular Proliferation, Migration, and Gene Expression Arterioscler. Thromb. Vasc. Biol., May 1, 2003; 23(5): 795 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. X. Rong, J. W. Berman, M. B. Taubman, and E. A. Fisher Lysophosphatidylcholine Stimulates Monocyte Chemoattractant Protein-1 Gene Expression in Rat Aortic Smooth Muscle Cells Arterioscler. Thromb. Vasc. Biol., October 1, 2002; 22(10): 1617 - 1623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cattaruzza, K. Schafer, and M. Hecker Cytokine-induced Down-regulation of zfm1/Splicing Factor-1 Promotes Smooth Muscle Cell Proliferation J. Biol. Chem., February 15, 2002; 277(8): 6582 - 6589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tedgui and Z. Mallat Anti-Inflammatory Mechanisms in the Vascular Wall Circ. Res., May 11, 2001; 88(9): 877 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Schmidt and D. M. Stern Chemokines on the Rise : MCP-1 and Restenosis Arterioscler. Thromb. Vasc. Biol., March 1, 2001; 21(3): 297 - 299. [Full Text] [PDF]
|
|
|
|
|
|
A. D. Schecter, B. Spirn, M. Rossikhina, P. L. A. Giesen, V. Bogdanov, J. T. Fallon, E. A. Fisher, L. M. Schnapp, Y. Nemerson, and M. B. Taubman Release of Active Tissue Factor by Human Arterial Smooth Muscle Cells Circ. Res., July 21, 2000; 87(2): 126 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alonso, Y. Bayon, M. Renedo, and M. S. Crespo Stimulation of Fc{gamma}R receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving I{kappa}B-{alpha} degradation and formation of p50/p65 NF-{kappa}B/Rel complexes Int. Immunol., April 1, 2000; 12(4): 547 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Inadera, T. Sekiya, T. Yoshimura, and K. Matsushima Molecular Analysis of the Inhibition of Monocyte Chemoattractant Protein-1 Gene Expression by Estrogens and Xenoestrogens in MCF-7 Cells Endocrinology, January 1, 2000; 141(1): 50 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ping, G. Boekhoudt, and J. M. Boss trans-Retinoic Acid Blocks Platelet-derived Growth Factor-BB-induced Expression of the Murine Monocyte Chemoattractant-1 Gene by Blocking the Assembly of a Promoter Proximal Sp1 Binding Site J. Biol. Chem., November 5, 1999; 274(45): 31909 - 31916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Poon, B. Liu, and M. B. Taubman Identification of a Novel Dexamethasone-Sensitive RNA-Destabilizing Region on Rat Monocyte Chemoattractant Protein 1 mRNA Mol. Cell. Biol., October 1, 1999; 19(10): 6471 - 6478. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |