JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, F.
Right arrow Articles by Dannenberg, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, F.
Right arrow Articles by Dannenberg, A. J.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Vol. 273, Issue 4, 2424-2428, January 23, 1998

Dihydroxy Bile Acids Activate the Transcription of Cyclooxygenase-2

Fan ZhangDagger §, Kotha SubbaramaiahDagger , Nasser AltorkiDagger §, and Andrew J. DannenbergDagger

From the  Departments of Medicine and Surgery and the § Department of Cardiothoracic Surgery, New York Hospital-Cornell Medical Center and the Dagger  Strang Cancer Prevention Center, New York, New York 10021

Bile acids, endogenous promoters of gastrointestinal cancer, activate protein kinase C (PKC) and the activator protein-1 (AP-1) transcription factor. Because other activators of PKC and AP-1 induce cyclooxygenase-2 (COX-2), we determined the effects of bile acids on the expression of COX-2 in human esophageal adenocarcinoma cells. Treatment with the dihydroxy bile acids chenodeoxycholate and deoxycholate resulted in an ~10-fold increase in the production of prostaglandin E2 (PGE2). Enhanced synthesis of PGE2 was associated with a marked increase in the levels of COX-2 mRNA and protein, with maximal effects at 8-12 and 12-24 h, respectively. In contrast, neither cholic acid nor conjugated bile acids affected the levels of COX-2 or the synthesis of PGE2. Nuclear run-off assays and transient transfections with a human COX-2 promoter construct showed that induction of COX-2 mRNA by chenodeoxycholate and deoxycholate was due to increased transcription. Bile acid-mediated induction of COX-2 was blocked by inhibitors of PKC activity, including calphostin C and staurosporine. Treatment with bile acid enhanced the phosphorylation of c-Jun and increased binding of AP-1 to DNA. These data are important because dihydroxy bile acid-mediated induction of COX-2 may explain, at least in part, the tumor-promoting effects of bile acids.


Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
MutagenesisHome page
G. J. S. Jenkins, J. Cronin, A. Alhamdani, N. Rawat, F. D'Souza, T. Thomas, Z. Eltahir, A. P. Griffiths, and J. N. Baxter
The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-{kappa}B activation in oesophageal cells, with a mechanism of action involving ROS
Mutagenesis, May 30, 2008; (2008) gen029v1.
[Abstract] [Full Text] [PDF]


Home page
GutHome page
S. Song, S. Guha, K. Liu, N. S Buttar, and R. S Bresalier
COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma
Gut, November 1, 2007; 56(11): 1512 - 1521.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
G. J.S. Jenkins, F. R. D'Souza, S. H. Suzen, Z. S. Eltahir, S. A. James, J. M. Parry, P. A. Griffiths, and J. N. Baxter
Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: the potential role of anti-oxidants in Barrett's oesophagus
Carcinogenesis, January 1, 2007; 28(1): 136 - 142.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
J. Silva, S. Dasgupta, G. Wang, K. Krishnamurthy, E. Ritter, and E. Bieberich
Lipids isolated from bone induce the migration of human breast cancer cells
J. Lipid Res., April 1, 2006; 47(4): 724 - 733.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Jaiswal, C. Lopez-Guzman, R. F. Souza, S. J. Spechler, and G. A. Sarosi Jr
Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line
Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G335 - G342.
[Abstract] [Full Text] [PDF]


Home page
GutHome page
H Kazumori, S Ishihara, M A K Rumi, Y Kadowaki, and Y Kinoshita
Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium
Gut, January 1, 2006; 55(1): 16 - 25.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
W. Wu, R. A. Silbajoris, Y. E. Whang, L. M. Graves, P. A. Bromberg, and J. M. Samet
p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression
Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L883 - L889.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
D. S. Alberts, M. E. Martinez, L. M. Hess, J. G. Einspahr, S. B. Green, A. K. Bhattacharyya, J. Guillen, M. Krutzsch, A. K. Batta, G. Salen, et al.
Phase III Trial of Ursodeoxycholic Acid To Prevent Colorectal Adenoma Recurrence
J Natl Cancer Inst, June 1, 2005; 97(11): 846 - 853.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
L. A.A. Brosens, C. A. Iacobuzio-Donahue, J. J. Keller, S. R. Hustinx, R. Carvalho, F. H. Morsink, L. M. Hylind, G. J. Offerhaus, F. M. Giardiello, and M. Goggins
Increased Cyclooxygenase-2 Expression in Duodenal Compared with Colonic Tissues in Familial Adenomatous Polyposis and Relationship to the -765G -> C COX-2 Polymorphism
Clin. Cancer Res., June 1, 2005; 11(11): 4090 - 4096.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
F. Zhang, J. Cheng, G. Lam, D. K. Jin, L. Vincent, N. R. Hackett, S. Wang, L. M. Young, B. Hempstead, R. G. Crystal, et al.
Adenovirus Vector E4 Gene Regulates Connexin 40 and 43 Expression in Endothelial Cells via PKA and PI3K Signal Pathways
Circ. Res., May 13, 2005; 96(9): 950 - 957.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois
Cyclooxygenase-2 and Epidermal Growth Factor Receptor: Pharmacologic Targets for Chemoprevention
J. Clin. Oncol., January 10, 2005; 23(2): 254 - 266.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
H. H.-X. Xia, S. T. Zhang, S. K. Lam, M. C.-M. Lin, H. F. Kung, and B. C.-Y. Wong
Expression of macrophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of bile acids and NSAIDs
Carcinogenesis, January 1, 2005; 26(1): 11 - 15.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
E. Cheong, K. Ivory, J. Doleman, M.L. Parker, M. Rhodes, and I.T. Johnson
Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest
Carcinogenesis, October 1, 2004; 25(10): 1945 - 1952.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
O. N. Tucker, A. J. Dannenberg, E. K. Yang, and T. J. Fahey III
Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines
Carcinogenesis, March 1, 2004; 25(3): 419 - 423.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
E. Im and J. D. Martinez
Ursodeoxycholic Acid (UDCA) Can Inhibit Deoxycholic Acid (DCA)-induced Apoptosis via Modulation of EGFR/Raf-1/ERK Signaling in Human Colon Cancer Cells
J. Nutr., February 1, 2004; 134(2): 483 - 486.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
D. Golijanin, J.-Y. Tan, A. Kazior, E. G. Cohen, P. Russo, G. Dalbagni, K. J. Auborn, K. Subbaramaiah, and A. J. Dannenberg
Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Are Overexpressed in Squamous Cell Carcinoma of the Penis
Clin. Cancer Res., February 1, 2004; 10(3): 1024 - 1031.
[Abstract] [Full Text] [PDF]


Home page
GutHome page
T J Jang, S K Min, J D Bae, K H Jung, J I Lee, J R Kim, and W S Ahn
Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux
Gut, January 1, 2004; 53(1): 27 - 33.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M. S. De Lorenzo, K. Yamaguchi, K. Subbaramaiah, and A. J. Dannenberg
Bryostatin-1 Stimulates the Transcription of Cyclooxygenase-2: Evidence for an Activator Protein-1-Dependent Mechanism
Clin. Cancer Res., October 15, 2003; 9(13): 5036 - 5043.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
F. Zhang, N. R. Hackett, G. Lam, J. Cheng, R. Pergolizzi, L. Luo, S. V. Shmelkov, J. Edelberg, R. G. Crystal, and S. Rafii
Green fluorescent protein selectively induces HSP70-mediated up-regulation of COX-2 expression in endothelial cells
Blood, September 15, 2003; 102(6): 2115 - 2121.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
X. Chen, N. Li, S. Wang, J. Hong, M. Fang, J. Yousselfson, P. Yang, R. A. Newman, R. A. Lubet, and C. S. Yang
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and {alpha}-difluoromethylornithine on tumorigenesis in a rat surgical model
Carcinogenesis, December 1, 2002; 23(12): 2095 - 2102.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Zhu, P. Hua, S. Rafiq, E. J. Waffner, M. E. Duffey, and P. Lance
Ca2+- and PKC-dependent stimulation of PGE2 synthesis by deoxycholic acid in human colonic fibroblasts
Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G503 - G510.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
B. S. Kaur and G. Triadafilopoulos
Acid- and bile-induced PGE2 release and hyperproliferation in Barrett's esophagus are COX-2 and PKC-epsilon dependent
Am J Physiol Gastrointest Liver Physiol, August 1, 2002; 283(2): G327 - G334.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
B. Glinghammar, H. Inoue, and J.J. Rafter
Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1
Carcinogenesis, May 1, 2002; 23(5): 839 - 845.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
R. A. Gupta and R. N. DuBois
Cyclooxygenase-2 Inhibitor Therapy for the Prevention of Esophageal Adenocarcinoma in Barrett's Esophagus
J Natl Cancer Inst, March 20, 2002; 94(6): 406 - 407.
[Full Text] [PDF]


Home page
CarcinogenesisHome page
V. de Ledinghen, H. Liu, F. Zhang, C. R. Lo, K. Subbaramaiah, A. J. Dannenberg, and M. J. Czaja
Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes
Carcinogenesis, January 1, 2002; 23(1): 73 - 79.
[Abstract] [Full Text] [PDF]


Home page
Ann. N. Y. Acad. Sci.Home page
A. J. DANNENBERG, N. K. ALTORKI, J. O. BOYLE, D. T. LIN, and K. SUBBARAMAIAH
Inhibition of Cyclooxygenase-2: An Approach to Preventing Cancer of the Upper Aerodigestive Tract
Ann. N.Y. Acad. Sci., December 1, 2001; 952(1): 109 - 115.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
K. Yoshimatsu, D. Golijanin, P. B. Paty, R. A. Soslow, P.-J. Jakobsson, R. A. DeLellis, K. Subbaramaiah, and A. J. Dannenberg
Inducible Microsomal Prostaglandin E Synthase Is Overexpressed in Colorectal Adenomas and Cancer
Clin. Cancer Res., December 1, 2001; 7(12): 3971 - 3976.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
K. Yoshimatsu, N. K. Altorki, D. Golijanin, F. Zhang, P.-J. Jakobsson, A. J. Dannenberg, and K. Subbaramaiah
Inducible Prostaglandin E Synthase Is Overexpressed in Non-Small Cell Lung Cancer
Clin. Cancer Res., September 1, 2001; 7(9): 2669 - 2674.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
X. Chen and C. S. Yang
Esophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis and chemoprevention
Carcinogenesis, August 1, 2001; 22(8): 1119 - 1129.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
S. RODRIGUES, Q.-D. NGUYEN, S. FAIVRE, E. BRUYNEEL, L. THIM, B. WESTLEY, F. MAY, G. FLATAU, M. MAREEL, C. GESPACH, et al.
Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase- and thromboxane A2 receptor-dependent signaling pathways
FASEB J, July 1, 2001; 15(9): 1517 - 1528.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
D. Qiao, S. V. Gaitonde, W. Qi, and J. D. Martinez
Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation
Carcinogenesis, June 1, 2001; 22(6): 957 - 964.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
E. O. Souto, H. Miyoshi, R. N. Dubois, and G. J. Gores
Kupffer cell-derived cyclooxygenase-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats
Am J Physiol Gastrointest Liver Physiol, May 1, 2001; 280(5): G805 - G811.
[Abstract] [Full Text] [PDF]


Home page
J Biomol ScreenHome page
K. Subbaramaiah, P. Bulic, Y. Lin, A. J. Dannenberg, and D. S. Pasco
Development and Use of a Gene Promoter-Based Screen to Identify Novel Inhibitors of Cyclooxygenase-2 Transcription
J Biomol Screen, April 1, 2001; 6(2): 101 - 110.
[Abstract] [PDF]


Home page
Annals of Clinical & Laboratory ScienceHome page
E. Fosslien
Mitochondrial Medicine - Molecular Pathology of Defective Oxidative Phosphorylation
Ann. Clin. Lab. Sci., January 1, 2001; 31(1): 25 - 67.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
F. W. Wiese, P. A. Thompson, and F. F. Kadlubar
Carcinogen substrate specificity of human COX-1 and COX-2
Carcinogenesis, January 1, 2001; 22(1): 5 - 10.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
D. Qiao, E. D. Stratagouleas, and J. D. Martinez
Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis
Carcinogenesis, January 1, 2001; 22(1): 35 - 41.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
B. S. Reddy, Y. Hirose, L. A. Cohen, B. Simi, I. Cooma, and C. V. Rao
Preventive Potential of Wheat Bran Fractions against Experimental Colon Carcinogenesis: Implications for Human Colon Cancer Prevention
Cancer Res., September 1, 2000; 60(17): 4792 - 4797.
[Abstract] [Full Text]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
M. Li, R. Lotan, B. Levin, E. Tahara, S. M. Lippman, and X.-C. Xu
Aspirin Induction of Apoptosis in Esophageal Cancer: A Potential for Chemoprevention
Cancer Epidemiol. Biomarkers Prev., June 1, 2000; 9(6): 545 - 549.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
B. S. Kaur, R. Ouatu-Lascar, M. B. Omary, and G. Triadafilopoulos
Bile salts induce or blunt cell proliferation in Barrett's esophagus in an acid-dependent fashion
Am J Physiol Gastrointest Liver Physiol, June 1, 2000; 278(6): G1000 - G1009.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. Subbaramaiah, P. Michaluart, M. B. Sporn, and A. J. Dannenberg
Ursolic Acid Inhibits Cyclooxygenase-2 Transcription in Human Mammary Epithelial Cells
Cancer Res., May 1, 2000; 60(9): 2399 - 2404.
[Abstract] [Full Text]


Home page
J. Biol. Chem.Home page
H. Sheng, J. Shao, D. A. Dixon, C. S. Williams, S. M. Prescott, R. N. DuBois, and R. D. Beauchamp
Transforming Growth Factor-beta 1 Enhances Ha-ras-induced Expression of Cyclooxygenase-2 in Intestinal Epithelial Cells via Stabilization of mRNA
J. Biol. Chem., February 25, 2000; 275(9): 6628 - 6635.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Z. Yan, K. Subbaramaiah, T. Camilli, F. Zhang, T. Tanabe, T. A. McCaffrey, A. J. Dannenberg, and B. B. Weksler
Benzo[a]pyrene Induces the Transcription of Cyclooxygenase-2 in Vascular Smooth Muscle Cells. EVIDENCE FOR THE INVOLVEMENT OF EXTRACELLULAR SIGNAL-REGULATED KINASE AND NF-kappa B
J. Biol. Chem., February 18, 2000; 275(7): 4949 - 4955.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
T. E. Crew, D. J.E. Elder, and C. Paraskeva
A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate
Carcinogenesis, January 1, 2000; 21(1): 69 - 77.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
H. Matsuura, M. Sakaue, K. Subbaramaiah, H. Kamitani, T. E. Eling, A. J. Dannenberg, T. Tanabe, H. Inoue, J. Arata, and A. M. Jetten
Regulation of Cyclooxygenase-2 by Interferon gamma and Transforming Growth Factor alpha in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells. ROLE OF MITOGEN-ACTIVATED PROTEIN KINASES
J. Biol. Chem., October 8, 1999; 274(41): 29138 - 29148.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
B. Glinghammar, K. Holmberg, and J. Rafter
Effects of colonic lumenal components on AP-1-dependent gene transcription in cultured human colon carcinoma cells
Carcinogenesis, June 1, 1999; 20(6): 969 - 976.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
P. Michaluart, J. L. Masferrer, A. M. Carothers, K. Subbaramaiah, B. S. Zweifel, C. Koboldt, J. R. Mestre, D. Grunberger, P. G. Sacks, T. Tanabe, et al.
Inhibitory Effects of Caffeic Acid Phenethyl Ester on the Activity and Expression of Cyclooxygenase-2 in Human Oral Epithelial Cells and in a Rat Model of Inflammation
Cancer Res., May 1, 1999; 59(10): 2347 - 2352.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
K. Subbaramaiah, N. Altorki, W. J. Chung, J. R. Mestre, A. Sampat, and A. J. Dannenberg
Inhibition of Cyclooxygenase-2 Gene Expression by p53
J. Biol. Chem., April 16, 1999; 274(16): 10911 - 10915.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
O. N. Tucker, A. J. Dannenberg, E. K. Yang, F. Zhang, L. Teng, J. M. Daly, R. A. Soslow, J. L. Masferrer, B. M. Woerner, A. T. Koki, et al.
Cyclooxygenase-2 Expression Is Up-Regulated in Human Pancreatic Cancer
Cancer Res., March 1, 1999; 59(5): 987 - 990.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
F. Zhang, N. K. Altorki, J. R. Mestre, K. Subbaramaiah, and A. J. Dannenberg
Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells
Carcinogenesis, March 1, 1999; 20(3): 445 - 451.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
N. N. Mahmoud, A. J. Dannenberg, R. T. Bilinski, J. R. Mestre, A. Chadburn, M. Churchill, C. Martucci, and M. M. Bertagnolli
Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis
Carcinogenesis, February 1, 1999; 20(2): 299 - 303.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
F.-Y. J. Lee, Y. Li, E. K. Yang, S. Q. Yang, H. Z. Lin, M. A. Trush, A. J. Dannenberg, and A. M. Diehl
Phenotypic abnormalities in macrophages from leptin-deficient, obese mice
Am J Physiol Cell Physiol, February 1, 1999; 276(2): C386 - C394.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
K. Subbaramaiah, W. J. Chung, and A. J. Dannenberg
Ceramide Regulates the Transcription of Cyclooxygenase-2. EVIDENCE FOR INVOLVEMENT OF EXTRACELLULAR SIGNAL-REGULATED KINASE/c-Jun N-TERMINAL KINASE AND p38 MITOGEN-ACTIVATED PROTEIN KINASE PATHWAYS
J. Biol. Chem., December 4, 1998; 273(49): 32943 - 32949.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. Nieto, P. Greenwel, S. L. Friedman, F. Zhang, A. J. Dannenberg, and A. I. Cederbaum
Ethanol and Arachidonic Acid Increase alpha 2(I) Collagen Expression in Rat Hepatic Stellate Cells Overexpressing Cytochrome P450 2E1. ROLE OF H2O2 AND CYCLOOXYGENASE-2
J. Biol. Chem., June 23, 2000; 275(26): 20136 - 20145.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Shao, H. Sheng, H. Inoue, J. D. Morrow, and R. N. DuBois
Regulation of Constitutive Cyclooxygenase-2 Expression in Colon Carcinoma Cells
J. Biol. Chem., October 20, 2000; 275(43): 33951 - 33956.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. Gupta, R. T. Stravitz, P. Dent, and P. B. Hylemon
Down-regulation of Cholesterol 7alpha -Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway
J. Biol. Chem., May 4, 2001; 276(19): 15816 - 15822.
[Abstract] [Full Text] [PDF]