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J Biol Chem, Vol. 273, Issue 41, 26292-26294, October 9, 1998
-Synuclein to Brain Vesicles Is Abolished by
Familial Parkinson's Disease Mutation
§,,
,
From the The presynaptic protein Department of Medical Biochemistry, Building
170, University of Aarhus, DK-8000 Aarhus C, Denmark, the
§ European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Federal Republic of Germany, and the Medical
Research Council Laboratory of Molecular Biology, Hills Road, Cambridge
CB2 2QH, United Kingdom
-synuclein has been
implicated in the pathogenesis of Parkinson's disease. First, two
missense mutations A30P and A53T cause inheritable early onset
Parkinson's disease in some families. Secondly, -synuclein is
present in Lewy bodies of affected nerve cells in the predominant
sporadic type of Parkinson's disease as well as in dementia with Lewy
bodies. We demonstrate in the rat optic system that a portion of
-synuclein is carried by the vesicle-moving fast component of axonal
transport and that it binds to rat brain vesicles through its
amino-terminal repeat region. We find -synuclein with the A30P
mutation of familial Parkinson's disease devoid of vesicle-binding
activity and propose that mutant -synuclein may accumulate, leading
to assembly into Lewy body filaments.
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M. Okochi, J. Walter, A. Koyama, S. Nakajo, M. Baba, T. Iwatsubo, L. Meijer, P. J. Kahle, and C. Haass Constitutive Phosphorylation of the Parkinson's Disease Associated alpha -Synuclein J. Biol. Chem., January 7, 2000; 275(1): 390 - 397. [Abstract] [Full Text] [PDF]
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P. H. Jensen, H. Hager, M. S. Nielsen, P. Hojrup, J. Gliemann, and R. Jakes alpha -Synuclein Binds to Tau and Stimulates the Protein Kinase A-catalyzed Tau Phosphorylation of Serine Residues 262 and 356 J. Biol. Chem., September 3, 1999; 274(36): 25481 - 25489. [Abstract] [Full Text] [PDF]
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N. Ostrerova, L. Petrucelli, M. Farrer, N. Mehta, P. Choi, J. Hardy, and B. Wolozin alpha -Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins J. Neurosci., July 15, 1999; 19(14): 5782 - 5791. [Abstract] [Full Text] [PDF]
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S. J. Wood, J. Wypych, S. Steavenson, J.-C. Louis, M. Citron, and A. L. Biere alpha -Synuclein Fibrillogenesis Is Nucleation-dependent. IMPLICATIONS FOR THE PATHOGENESIS OF PARKINSON'S DISEASE J. Biol. Chem., July 9, 1999; 274(28): 19509 - 19512. [Abstract] [Full Text] [PDF]
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B. I. Giasson, K. Uryu, J. Q. Trojanowski, and V. M.-Y Lee Mutant and Wild Type Human alpha -Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro J. Biol. Chem., March 19, 1999; 274(12): 7619 - 7622. [Abstract] [Full Text] [PDF]
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P. H. Jensen, K. Islam, J. Kenney, M. S. Nielsen, J. Power, and W. P. Gai Microtubule-associated Protein 1B Is a Component of Cortical Lewy Bodies and Binds alpha -Synuclein Filaments J. Biol. Chem., July 7, 2000; 275(28): 21500 - 21507. [Abstract] [Full Text] [PDF]
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E. Jo, J. McLaurin, C. M. Yip, P. St. George-Hyslop, and P. E. Fraser alpha -Synuclein Membrane Interactions and Lipid Specificity J. Biol. Chem., October 27, 2000; 275(44): 34328 - 34334. [Abstract] [Full Text] [PDF]
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R. J. Perrin, W. S. Woods, D. F. Clayton, and J. M. George Interaction of Human alpha -Synuclein and Parkinson's Disease Variants with Phospholipids. STRUCTURAL ANALYSIS USING SITE-DIRECTED MUTAGENESIS J. Biol. Chem., October 27, 2000; 275(44): 34393 - 34398. [Abstract] [Full Text] [PDF]
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V. N. Uversky, J. Li, and A. L. Fink Evidence for a Partially Folded Intermediate in alpha -Synuclein Fibril Formation J. Biol. Chem., March 30, 2001; 276(14): 10737 - 10744. [Abstract] [Full Text] [PDF]
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Y. Leng, T. N. Chase, and M. C. Bennett Muscarinic Receptor Stimulation Induces Translocation of an alpha -Synuclein Oligomer from Plasma Membrane to a Light Vesicle Fraction in Cytoplasm J. Biol. Chem., July 20, 2001; 276(30): 28212 - 28218. [Abstract] [Full Text] [PDF]
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M. S. Nielsen, H. Vorum, E. Lindersson, and P. H. Jensen Ca2+ Binding to alpha -Synuclein Regulates Ligand Binding and Oligomerization J. Biol. Chem., June 15, 2001; 276(25): 22680 - 22684. [Abstract] [Full Text] [PDF]
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J. Y. Sung, J. Kim, S. R. Paik, J. H. Park, Y. S. Ahn, and K. C. Chung Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of alpha -Synuclein J. Biol. Chem., July 13, 2001; 276(29): 27441 - 27448. [Abstract] [Full Text] [PDF]
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