| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 41, 26338-26348, October 9, 1998
From the Department of Biology, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139
The class B type I scavenger
receptor, (SR-BI), is a member of the CD36 superfamily of proteins and
is a physiologically relevant, high affinity cell surface high density
lipoprotein (HDL) receptor that mediates selective lipid uptake. The
mechanism of selective lipid uptake is fundamentally different from
that of classic receptor-mediated uptake via coated pits and vesicles
(e.g. the low density lipoprotein receptor pathway) in that
it involves efficient transfer of the lipids, but not the outer shell
proteins, from HDL to cells. The abilities of SR-BI and CD36, both of
which are class B scavenger receptors, to bind HDL and mediate cellular
uptake of HDL-associated lipid when transiently expressed in COS cells
were examined. For these experiments, the binding of HDL to cells was
assessed using either 125I- or Alexa (a fluorescent
dye)-HDL in which the apolipoproteins on the surface of the HDL
particles were covalently modified. Lipid transfer was measured using
HDL noncovalently labeled by the fluorescent lipid
1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate.
Although both mSR-BI and human CD36 (hCD36) could mediate the binding
of HDL in a punctate pattern across the surfaces of cells, only mSR-BI
efficiently mediated the transfer of lipid to the cells. Analysis of
point mutants established that the major sites of fatty acylation of
mSR-BI are Cys462 and Cys470 and that fatty
acylation is not required for receptor clustering, HDL binding, or
efficient lipid transfer. Generation of mSR-BI/hCD36 domain swap
chimeras showed that the differences in lipid uptake activities between
mSR-BI and hCD36 were not due to differences between their two sets of
transmembrane and cytoplasmic domains but rather result from
differences in their large extracellular loop domains. These results
show that high affinity binding to a cell surface receptor is not
sufficient to ensure efficient cellular lipid uptake from HDL. Thus,
SR-BI-mediated binding combined with SR-BI-dependent
facilitated transfer of lipid from the HDL particle to the cell appears
to be the most likely mechanism for the bulk of the selective uptake of
cholesteryl esters from HDL to the liver and steroidogenic tissues.
This article has been cited by other articles:
|
|
 |
|
  M. Z. Ashraf, N. S. Kar, X. Chen, J. Choi, R. G. Salomon, M. Febbraio, and E. A. Podrez Specific Oxidized Phospholipids Inhibit Scavenger Receptor BI-mediated Selective Uptake of Cholesteryl Esters J. Biol. Chem., April 18, 2008; 283(16): 10408 - 10414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. F. Nieland, J. T. Shaw, F. A. Jaipuri, Z. Maliga, J. L. Duffner, A. N. Koehler, and M. Krieger Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI J. Lipid Res., August 1, 2007; 48(8): 1832 - 1845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Deakin, X. Moren, and R. W. James HDL Oxidation Compromises its Influence on Paraoxonase-1 Secretion and its Capacity to Modulate Enzyme Activity Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 1146 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, A. M. Ahmed, N. McFarlane, C. Capone, D. R. Boreham, R. Truant, S. A. Igdoura, and B. L. Trigatti Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways J. Lipid Res., February 1, 2007; 48(2): 405 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Brundert, J. Heeren, M. Bahar-Bayansar, A. Ewert, K. J. Moore, and F. Rinninger Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI J. Lipid Res., November 1, 2006; 47(11): 2408 - 2421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cocquerel, C. Voisset, and J. Dubuisson Hepatitis C virus entry: potential receptors and their biological functions. J. Gen. Virol., May 1, 2006; 87(Pt 5): 1075 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lan and D. L. Silver Fenofibrate Induces a Novel Degradation Pathway for Scavenger Receptor B-I Independent of PDZK1 J. Biol. Chem., June 17, 2005; 280(24): 23390 - 23396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Parathath, M. A. Connelly, R. A. Rieger, S. M. Klein, N. A. Abumrad, M. de la Llera-Moya, C. R. Iden, G. H. Rothblat, and D. L. Williams Changes in Plasma Membrane Properties and Phosphatidylcholine Subspecies of Insect Sf9 Cells Due to Expression of Scavenger Receptor Class B, Type I, and CD36 J. Biol. Chem., October 1, 2004; 279(40): 41310 - 41318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. F. Nieland, A. Chroni, M. L. Fitzgerald, Z. Maliga, V. I. Zannis, T. Kirchhausen, and M. Krieger Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide J. Lipid Res., July 1, 2004; 45(7): 1256 - 1265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Camarota, J. M. Chapman, D. Y. Hui, and P. N. Howles Carboxyl Ester Lipase Cofractionates with Scavenger Receptor BI in Hepatocyte Lipid Rafts and Enhances Selective Uptake and Hydrolysis of Cholesteryl Esters from HDL3 J. Biol. Chem., June 25, 2004; 279(26): 27599 - 27606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. M. Eckhardt, L. Cai, B. Sun, N. R. Webb, and D. R. van der Westhuyzen High Density Lipoprotein Uptake by Scavenger Receptor SR-BII J. Biol. Chem., April 2, 2004; 279(14): 14372 - 14381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. de Beer, L. W. Castellani, L. Cai, A. J. Stromberg, F. C. de Beer, and D. R. van der Westhuyzen ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36 J. Lipid Res., April 1, 2004; 45(4): 706 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Thuahnai, S. Lund-Katz, P. Dhanasekaran, M. de la Llera-Moya, M. A. Connelly, D. L. Williams, G. H. Rothblat, and M. C. Phillips Scavenger Receptor Class B Type I-mediated Cholesteryl Ester-selective Uptake and Efflux of Unesterified Cholesterol: INFLUENCE OF HIGH DENSITY LIPOPROTEIN SIZE AND STRUCTURE J. Biol. Chem., March 26, 2004; 279(13): 12448 - 12455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Cao, K. Murao, H. Imachi, X. Yu, H. Abe, A. Yamauchi, M. Niimi, A. Miyauchi, N. C. W. Wong, and T. Ishida A Mutant High-Density Lipoprotein Receptor Inhibits Proliferation of Human Breast Cancer Cells Cancer Res., February 15, 2004; 64(4): 1515 - 1521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Liu, G. Bhattacharjee, W. Boisvert, R. Dilley, and T. Edgington In Vivo Interrogation of the Molecular Display of Atherosclerotic Lesion Surfaces Am. J. Pathol., November 1, 2003; 163(5): 1859 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Silver, N. Wang, and S. Vogel Identification of Small PDZK1-associated Protein, DD96/MAP17, as a Regulator of PDZK1 and Plasma High Density Lipoprotein Levels J. Biol. Chem., August 1, 2003; 278(31): 28528 - 28532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Connelly, M. de la Llera-Moya, Y. Peng, D. Drazul-Schrader, G. H. Rothblat, and D. L. Williams Separation of Lipid Transport Functions by Mutations in the Extracellular Domain of Scavenger Receptor Class B, Type I J. Biol. Chem., July 3, 2003; 278(28): 25773 - 25782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rigotti, H. E. Miettinen, and M. Krieger The Role of the High-Density Lipoprotein Receptor SR-BI in the Lipid Metabolism of Endocrine and Other Tissues Endocr. Rev., June 1, 2003; 24(3): 357 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Osgood, D. Corella, S. Demissie, L. A. Cupples, P. W. F. Wilson, J. B. Meigs, E. J. Schaefer, O. Coltell, and J. M. Ordovas Genetic Variation at the Scavenger Receptor Class B Type I Gene Locus Determines Plasma Lipoprotein Concentrations and Particle Size and Interacts with Type 2 Diabetes: The Framingham Study J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2869 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Thuahnai, S. Lund-Katz, G. M. Anantharamaiah, D. L. Williams, and M. C. Phillips A quantitative analysis of apolipoprotein binding to SR-BI: multiple binding sites for lipid-free and lipid-associated apolipoproteins J. Lipid Res., June 1, 2003; 44(6): 1132 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heeren, T. Grewal, A. Laatsch, D. Rottke, F. Rinninger, C. Enrich, and U. Beisiegel Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization J. Biol. Chem., April 11, 2003; 278(16): 14370 - 14378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Temel, J. S. Parks, and D. L. Williams Enhancement of Scavenger Receptor Class B Type I-mediated Selective Cholesteryl Ester Uptake from apoA-I-/- High Density Lipoprotein (HDL) by Apolipoprotein A-I Requires HDL Reorganization by Lecithin Cholesterol Acyltransferase J. Biol. Chem., February 7, 2003; 278(7): 4792 - 4799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vinals, S. Xu, E. Vasile, and M. Krieger Identification of the N-Linked Glycosylation Sites on the High Density Lipoprotein (HDL) Receptor SR-BI and Assessment of Their Effects on HDL Binding and Selective Lipid Uptake J. Biol. Chem., February 7, 2003; 278(7): 5325 - 5332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Connelly, G. Kellner-Weibel, G. H. Rothblat, and D. L. Williams SR-BI-directed HDL-cholesteryl ester hydrolysis J. Lipid Res., February 1, 2003; 44(2): 331 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Green, M. del Pilar Molina Portela, E. N. St. Jean, E. B. Lugli, and J. Raper Evidence for a Trypanosoma brucei Lipoprotein Scavenger Receptor J. Biol. Chem., January 3, 2003; 278(1): 422 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. F. Nieland, M. Penman, L. Dori, M. Krieger, and T. Kirchhausen Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI PNAS, November 26, 2002; 99(24): 15422 - 15427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Silver A Carboxyl-terminal PDZ-interacting Domain of Scavenger Receptor B, Type I Is Essential for Cell Surface Expression in Liver J. Biol. Chem., September 6, 2002; 277(37): 34042 - 34047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Liu and M. Krieger Highly Purified Scavenger Receptor Class B, Type I Reconstituted into Phosphatidylcholine/Cholesterol Liposomes Mediates High Affinity High Density Lipoprotein Binding and Selective Lipid Uptake J. Biol. Chem., September 6, 2002; 277(37): 34125 - 34135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, H.-Y. Kan, S. Lavrentiadou, M. Krieger, and V. Zannis Reconstituted Discoidal ApoE-Phospholipid Particles Are Ligands for the Scavenger Receptor BI. THE AMINO-TERMINAL 1-165 DOMAIN OF ApoE SUFFICES FOR RECEPTOR BINDING J. Biol. Chem., June 7, 2002; 277(24): 21149 - 21157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Liu, M. Krieger, H.-Y. Kan, and V. I. Zannis The Effects of Mutations in Helices 4 and 6 of ApoA-I on Scavenger Receptor Class B Type I (SR-BI)-mediated Cholesterol Efflux Suggest That Formation of a Productive Complex between Reconstituted High Density Lipoprotein and SR-BI Is Required for Efficient Lipid Transport J. Biol. Chem., June 7, 2002; 277(24): 21576 - 21584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Hullinger, R. L. Panek, X. Xu, and S. K. Karathanasis p21-activated Kinase-1 (PAK1) Inhibition of the Human Scavenger Receptor Class B, Type I Promoter in Macrophages Is Independent of PAK1 Kinase Activity, but Requires the GTPase-binding Domain J. Biol. Chem., December 7, 2001; 276(50): 46807 - 46814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Thuahnai, S. Lund-Katz, D. L. Williams, and M. C. Phillips Scavenger Receptor Class B, Type I-mediated Uptake of Various Lipids into Cells. INFLUENCE OF THE NATURE OF THE DONOR PARTICLE INTERACTION WITH THE RECEPTOR J. Biol. Chem., November 16, 2001; 276(47): 43801 - 43808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V.T. Lobo, L. Huerta, N. Ruiz-Velasco, E. Teixeiro, P. de la Cueva, A. Celdran, A. Martin-Hidalgo, M. A. Vega, and R. Bragado Localization of the Lipid Receptors CD36 and CLA-1/SR-BI in the Human Gastrointestinal Tract: Towards the Identification of Receptors Mediating the Intestinal Absorption of Dietary Lipids J. Histochem. Cytochem., October 1, 2001; 49(10): 1253 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Gillotte-Taylor, A. Boullier, J. L. Witztum, D. Steinberg, and O. Quehenberger Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein J. Lipid Res., September 1, 2001; 42(9): 1474 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. S. de Villiers, L. Cai, N. R. Webb, M. C. de Beer, D. R. van der Westhuyzen, and F. C. de Beer CD36 does not play a direct role in HDL or LDL metabolism J. Lipid Res., August 1, 2001; 42(8): 1231 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. von Eckardstein, J.-R. Nofer, and G. Assmann High Density Lipoproteins and Arteriosclerosis : Role of Cholesterol Efflux and Reverse Cholesterol Transport Arterioscler. Thromb. Vasc. Biol., January 1, 2001; 21(1): 13 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Terpstra, E. S. van Amersfoort, A. G. van Velzen, J. Kuiper, and T. J. C. van Berkel Hepatic and Extrahepatic Scavenger Receptors : Function in Relation to Disease Arterioscler. Thromb. Vasc. Biol., August 1, 2000; 20(8): 1860 - 1872. [Full Text] [PDF]
|
|
|
|
|
|
C. C. Hedrick, K. Hassan, G. P. Hough, J. Yoo, S. Simzar, C. R. Quinto, S.-M. Kim, A. Dooley, S. Langi, S. Y. Hama, et al. Short-Term Feeding of Atherogenic Diet to Mice Results in Reduction of HDL and Paraoxonase That May Be Mediated by an Immune Mechanism Arterioscler. Thromb. Vasc. Biol., August 1, 2000; 20(8): 1946 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Herijgers, M. Van Eck, S. J. A. Korporaal, P. M. Hoogerbrugge, and T. J. C. Van Berkel Relative importance of the LDL receptor and scavenger receptor class B in the {beta}-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages J. Lipid Res., July 1, 2000; 41(7): 1163 - 1171. [Abstract] [Full Text]
|
|
|
|
|
|
E. I. Posse de Chaves, D. E. Vance, R. B. Campenot, R. S. Kiss, and J. E. Vance Uptake of Lipoproteins for Axonal Growth of Sympathetic Neurons J. Biol. Chem., June 23, 2000; 275(26): 19883 - 19890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pilon, O. Briand, S. Lestavel, C. Copin, Z. Majd, J.-C. Fruchart, G. Castro, and V. Clavey Apolipoprotein AII Enrichment of HDL Enhances Their Affinity for Class B Type I Scavenger Receptor but Inhibits Specific Cholesteryl Ester Uptake Arterioscler. Thromb. Vasc. Biol., April 1, 2000; 20(4): 1074 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Gu, R. Lawrence, and M. Krieger Dissociation of the High Density Lipoprotein and Low Density Lipoprotein Binding Activities of Murine Scavenger Receptor Class B Type I (mSR-BI) Using Retrovirus Library-based Activity Dissection J. Biol. Chem., March 24, 2000; 275(13): 9120 - 9130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ji, N. Wang, R. Ramakrishnan, E. Sehayek, D. Huszar, J. L. Breslow, and A. R. Tall Hepatic Scavenger Receptor BI Promotes Rapid Clearance of High Density Lipoprotein Free Cholesterol and Its Transport into Bile J. Biol. Chem., November 19, 1999; 274(47): 33398 - 33402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Matveev, D. R. van der Westhuyzen, and E. J. Smart Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages J. Lipid Res., September 1, 1999; 40(9): 1647 - 1654. [Abstract] [Full Text]
|
|
|
|
|
|
B. Trigatti, H. Rayburn, M. Vinals, A. Braun, H. Miettinen, M. Penman, M. Hertz, M. Schrenzel, L. Amigo, A. Rigotti, et al. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology PNAS, August 3, 1999; 96(16): 9322 - 9327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. V. Rodrigueza, S. T. Thuahnai, R. E. Temel, S. Lund-Katz, M. C. Phillips, and D. L. Williams Mechanism of Scavenger Receptor Class B Type I-mediated Selective Uptake of Cholesteryl Esters from High Density Lipoprotein to Adrenal Cells J. Biol. Chem., July 16, 1999; 274(29): 20344 - 20350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Febbraio, N. A. Abumrad, D. P. Hajjar, K. Sharma, W. Cheng, S. F. A. Pearce, and R. L. Silverstein A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism J. Biol. Chem., July 2, 1999; 274(27): 19055 - 19062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. de la Llera-Moya, G. H. Rothblat, M. A. Connelly, G. Kellner-Weibel, S. W. Sakr, M. C. Phillips, and D. L. Williams Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface J. Lipid Res., March 1, 1999; 40(3): 575 - 580. [Abstract] [Full Text]
|
|
|
|
|
|
K. A. Melkonian, A. G. Ostermeyer, J. Z. Chen, M. G. Roth, and D. A. Brown Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts. MANY RAFT PROTEINS ARE ACYLATED, WHILE FEW ARE PRENYLATED J. Biol. Chem., February 5, 1999; 274(6): 3910 - 3917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. H. Fidge High density lipoprotein receptors, binding proteins, and ligands J. Lipid Res., February 1, 1999; 40(2): 187 - 201. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Connelly, S. M. Klein, S. Azhar, N. A. Abumrad, and D. L. Williams Comparison of Class B Scavenger Receptors, CD36 and Scavenger Receptor BI (SR-BI), Shows That Both Receptors Mediate High Density Lipoprotein-Cholesteryl Ester Selective Uptake but SR-BI Exhibits a Unique Enhancement of Cholesteryl Ester Uptake J. Biol. Chem., January 1, 1999; 274(1): 41 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Gu, K. Kozarsky, and M. Krieger Scavenger Receptor Class B, Type I-mediated [3H]Cholesterol Efflux to High and Low Density Lipoproteins Is Dependent on Lipoprotein Binding to the Receptor J. Biol. Chem., September 22, 2000; 275(39): 29993 - 30001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, D. L. Silver, J. D. Smith, and A. R. Tall Scavenger Receptor-BI Inhibits ATP-binding Cassette Transporter 1- mediated Cholesterol Efflux in Macrophages J. Biol. Chem., September 29, 2000; 275(40): 30794 - 30800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ohgami, R. Nagai, M. Ikemoto, H. Arai, A. Kuniyasu, S. Horiuchi, and H. Nakayama CD36, a Member of the Class B Scavenger Receptor Family, as a Receptor for Advanced Glycation End Products J. Biol. Chem., January 26, 2001; 276(5): 3195 - 3202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Greene, J. W. Skeggs, and R. E. Morton Elevated Triglyceride Content Diminishes the Capacity of High Density Lipoprotein to Deliver Cholesteryl Esters via the Scavenger Receptor Class B Type I (SR-BI) J. Biol. Chem., February 9, 2001; 276(7): 4804 - 4811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ikemoto, H. Arai, D. Feng, K. Tanaka, J. Aoki, N. Dohmae, K. Takio, H. Adachi, M. Tsujimoto, and K. Inoue Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I PNAS, June 6, 2000; 97(12): 6538 - 6543. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
