HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Badea, T. C. Articles by Rus, H. Search for Related Content PubMed PubMed Citation Articles by Badea, T. C. Articles by Rus, H. Social Bookmarking                      What's this?

J Biol Chem, Vol. 273, Issue 41, 26977-26981, October 9, 1998

Molecular Cloning and Characterization of RGC-32, a Novel Gene Induced by Complement Activation in Oligodendrocytes

From the Department of Pathology, University of Maryland, School of Medicine, Baltimore, Maryland 21201

Sublytic complement activation on oligodendrocytes (OLG) down-regulates expression of myelin genes and induces cell cycle in culture. Differential display (DD) was used to search for new genes whose expression is altered in response to complement and that may be involved in cell cycle activation. DD bands showing either increased or decreased mRNA expression in response to complement were identified and designated Response Genes to Complement (RGC) 1-32. RGC-1 is identical with heat shock protein 105, RGC-2 with poly(ADP-ribose) polymerase, and RGC-10 with IP-10. A new gene, RGC-32, that encodes a protein of 137 amino acids was cloned. RGC-32 has no homology with other known proteins, and contains no motif that would indicate its function. In OLG, the mRNA expression was increased by complement activation and by terminal complement complex assembly. RGC-32 protein was localized in the cytoplasm and co-immunoprecipitated with cdc2 kinase. Overexpression of RGC-32 increased DNA synthesis in OLGxC6 glioma cell hybrids. These results suggest that RGC-32 may play a role in cell cycle activation.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				T. Matsui, J. E. Connolly, M. Michnevitz, D. Chaussabel, C.-I Yu, C. Glaser, S. Tindle, M. Pypaert, H. Freitas, B. Piqueras, et al. CD2 Distinguishes Two Subsets of Human Plasmacytoid Dendritic Cells with Distinct Phenotype and Functions J. Immunol., June 1, 2009; 182(11): 6815 - 6823. [Abstract] [Full Text] [PDF]

				T. Miyashita, M. Wintzer, T. Kurotani, T. Konishi, N. Ichinohe, and K. S. Rockland Neurotrophin-3 Is Involved in the Formation of Apical Dendritic Bundles in Cortical Layer 2 of the Rat Cereb Cortex, May 15, 2009; (2009) bhp093v1. [Abstract] [Full Text] [PDF]

				E.-S. Park, S. Choi, K. N. Muse, T. E. Curry Jr., and M. Jo Response Gene to Complement 32 Expression Is Induced by the Luteinizing Hormone (LH) Surge and Regulated by LH-Induced Mediators in the Rodent Ovary Endocrinology, June 1, 2008; 149(6): 3025 - 3036. [Abstract] [Full Text] [PDF]

				F. Li, Z. Luo, W. Huang, Q. Lu, C. S. Wilcox, P. A. Jose, and S. Chen Response Gene to Complement 32, a Novel Regulator for Transforming Growth Factor-beta-induced Smooth Muscle Differentiation of Neural Crest Cells J. Biol. Chem., April 6, 2007; 282(14): 10133 - 10137. [Abstract] [Full Text] [PDF]

				I J Bujalska, M Quinkler, J W Tomlinson, C T Montague, D M Smith, and P M Stewart Expression profiling of 11{beta}-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes. J. Mol. Endocrinol., October 1, 2006; 37(2): 327 - 340. [Abstract] [Full Text] [PDF]

				M. Fosbrink, F. Niculescu, V. Rus, M. L. Shin, and H. Rus C5b-9-induced Endothelial Cell Proliferation and Migration Are Dependent on Akt Inactivation of Forkhead Transcription Factor FOXO1 J. Biol. Chem., July 14, 2006; 281(28): 19009 - 19018. [Abstract] [Full Text] [PDF]

				T. Badea, F. Niculescu, L. Soane, M. Fosbrink, H. Sorana, V. Rus, M. L. Shin, and H. Rus RGC-32 Increases p34CDC2 Kinase Activity and Entry of Aortic Smooth Muscle Cells into S-phase J. Biol. Chem., January 4, 2002; 277(1): 502 - 508. [Abstract] [Full Text]

				N. Yokota, M. Uchijima, S. Nishizawa, H. Namba, Y. Koide, and H. A. Kontos Identification of Differentially Expressed Genes in Rat Hippocampus After Transient Global Cerebral Ischemia Using Subtractive cDNA Cloning Based on Polymerase Chain Reaction Editorial Comment Stroke, January 1, 2001; 32(1): 168 - 174. [Abstract] [Full Text] [PDF]