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J Biol Chem, Vol. 273, Issue 43, 27794-27799, October 23, 1998
From the UCLA Molecular Biology Institute, Los Angeles, California
90095-1570
Transcription factor IIH (TFIIH) is involved both
in transcription initiation by RNA polymerase II and in nucleotide
excision-repair. Nucleotide excision-repair occurs at higher rates in
transcriptionally active regions of the genome. Genetic studies
indicate that this transcription-coupled repair is dependent on the
Cockayne syndrome group A and B proteins, as well as TFIIH subunits.
Previous work indicated that Cockayne syndrome group B interacts with
RNA polymerase II molecules engaged in ternary complexes containing DNA
and RNA. Evidence presented here indicates that this complex can
interact with a factor containing the TFIIH core subunits p62 and
xeroderma pigmentosum subunit B/excision repair cross-complementing 3. The targeting of TFIIH or a TFIIH-like repair factor to
transcriptionally active DNA indicates a potential mechanism for
transcription-coupled repair in human cells.
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