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J Biol Chem, Vol. 273, Issue 45, 29424-29429, November 6, 1998
Chain toward Intracellular
Degradation
From Unité de Biologie des Interactions Cellulaires, URA CNRS
1960, Institut Pasteur, 25 rue du Docteur Roux,
75724 Paris Cedex 15, France
During receptor-mediated endocytosis, most growth
factor receptors are transported to late endocytic compartments and
degraded. This process is important to control their expression on the
cell surface and requires sorting in early endocytic compartments. Little is known about the mechanisms and the signals involved. We have
studied the signal involved in targeting the interleukin 2 receptor 
chain (IL2R), a member of the cytokine receptor superfamily, toward
degradation after internalization. We show that a motif of 8 amino
acids in the cytosolic tail of IL2R is sufficient to target a
normally recycling receptor toward degradation. Deletion of this signal
strongly impairs IL2R degradation. Further molecular
characterization of the motif shows that it does not resemble the well
documented tyrosine and dileucine families of trafficking signals.
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