| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 46, 30147-30156, November 13, 1998
From The Wenner-Gren Institute, Arrhenius Laboratories F3,
Stockholm University, S-106 91 Stockholm, Sweden
Brown adipose tissue hyperplasia is a fundamental
response to low ambient temperature. We show here that cold exposure of an animal markedly increased the phosphorylation of mitogen-activated protein kinase (p42/p44) Erk1 and Erk2 in brown adipose tissue, and
protected cells in the tissue from apoptosis. We also show that
cessation of the sympathetic stimulus, by transferring cold-adapted animals to 28 °C, caused an increased rate of apoptosis in the tissue. In primary cultures of brown adipose tissue, norepinephrine (NE) stimulated both the phosphorylation and the activity of Erk1/2 via
the Erk kinase MEK, and protected the cells form apoptosis. Similarly,
agonist stimulation of 
1- and 
-adrenergic
receptors and increases in the intracellular level of Ca2+
and cAMP stimulated the phosphorylation of Erk1/2. Agonist stimulation of 1- and -adrenergic receptors, and increased
intracellular cAMP level also promoted the cell survival. Furthermore,
NE stimulated the expression and secretion of basic fibroblast growth
factor (bFGF), which further promoted the cell survival via
MEK-dependent activation of Erk1/2. In essence, we show
that Erk1/2 has a critical role in promoting NE- and
bFGF-dependent survival of brown adipocytes, and propose
that NE- and bFGF-dependent regulation of the cell survival
is involved in the cold-induced hyperplasia of brown adipose tissue.
This article has been cited by other articles:
|
|
 |
|
  F. Lirussi, Z. Rakotoniaina, S. Madani, F. Goirand, M. Breuiller-Fouche, M.-J. Leroy, P. Sagot, J. J. Morrison, M. Dumas, and M. Bardou ADRB3 Adrenergic Receptor Is a Key Regulator of Human Myometrial Apoptosis and Inflammation During Chorioamnionitis Biol Reprod, March 1, 2008; 78(3): 497 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kanzleiter, T. Schneider, I. Walter, F. Bolze, C. Eickhorst, G. Heldmaier, S. Klaus, and M. Klingenspor Evidence for Nr4a1 as a cold-induced effector of brown fat thermogenesis Physiol Genomics, December 14, 2005; 24(1): 37 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Petrovic, A. Korac, B. Buzadzic, and B. Korac The effects of L-arginine and L-NAME supplementation on redox-regulation and thermogenesis in interscapular brown adipose tissue J. Exp. Biol., November 15, 2005; 208(22): 4263 - 4271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Hupfeld, J. L. Resnik, S. Ugi, and J. M. Olefsky Insulin-induced {beta}-Arrestin1 Ser-412 Phosphorylation Is a Mechanism for Desensitization of ERK Activation by G{alpha}i-coupled Receptors J. Biol. Chem., January 14, 2005; 280(2): 1016 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. CANNON and J. NEDERGAARD Brown Adipose Tissue: Function and Physiological Significance Physiol Rev, January 1, 2004; 84(1): 277 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Porras, S. Zuluaga, A. Valladares, A. M. Alvarez, B. Herrera, I. Fabregat, and M. Benito Long-Term Treatment with Insulin Induces Apoptosis in Brown Adipocytes: Role of Oxidative Stress Endocrinology, December 1, 2003; 144(12): 5390 - 5401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Gronning, A. Cederberg, N. Miura, S. Enerback, and K. Tasken Insulin and TNF{alpha} Induce Expression of the Forkhead Transcription Factor Gene Foxc2 in 3T3-L1 Adipocytes via PI3K and ERK 1/2-Dependent Pathways Mol. Endocrinol., April 1, 2002; 16(4): 873 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Dincer, N. Gangopadhyay, R. Wang, and B. D. Uhal Norepinephrine induces alveolar epithelial apoptosis mediated by {alpha}-, {beta}-, and angiotensin receptor activation Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L624 - L630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Ballif and J. Blenis Molecular Mechanisms Mediating Mammalian Mitogen-activated Protein Kinase (MAPK) Kinase (MEK)-MAPK Cell Survival Signals Cell Growth Differ., August 1, 2001; 12(8): 397 - 408. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Henaff, S. N. Hatem, and J.-J. Mercadier Low Catecholamine Concentrations Protect Adult Rat Ventricular Myocytes against Apoptosis through cAMP-Dependent Extracellular Signal-Regulated Kinase Activation Mol. Pharmacol., April 13, 2001; 58(6): 1546 - 1553. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. Lawlor and P. Rotwein Insulin-Like Growth Factor-Mediated Muscle Cell Survival: Central Roles for Akt and Cyclin-Dependent Kinase Inhibitor p21 Mol. Cell. Biol., December 1, 2000; 20(23): 8983 - 8995. [Abstract] [Full Text]
|
|
|
|
|
|
D. K. Grammatopoulos, H. S. Randeva, M. A. Levine, E. S. Katsanou, and E. W. Hillhouse Urocortin, but Not Corticotropin-Releasing Hormone (CRH), Activates the Mitogen-Activated Protein Kinase Signal Transduction Pathway in Human Pregnant Myometrium: An Effect Mediated via R1{{alpha}} and R2{beta} CRH Receptor Subtypes and Stimulation of Gq-Proteins Mol. Endocrinol., December 1, 2000; 14(12): 2076 - 2091. [Abstract] [Full Text]
|
|
|
|
|
|
J. M. Fredriksson, J. M. Lindquist, G. E. Bronnikov, and J. Nedergaard Norepinephrine Induces Vascular Endothelial Growth Factor Gene Expression in Brown Adipocytes through a beta -Adrenoreceptor/cAMP/Protein Kinase A Pathway Involving Src but Independently of Erk1/2 J. Biol. Chem., April 28, 2000; 275(18): 13802 - 13811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Bronnikov, S.-J. Zhang, B. Cannon, and J. Nedergaard A Dual Component Analysis Explains the Distinctive Kinetics of cAMP Accumulation in Brown Adipocytes J. Biol. Chem., December 31, 1999; 274(53): 37770 - 37780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Guardiola-Diaz, S. Rehnmark, N. Usuda, T. Albrektsen, D. Feltkamp, J.-A. Gustafsson, and S. E. H. Alexson Rat Peroxisome Proliferator-activated Receptors and Brown Adipose Tissue Function during Cold Acclimatization J. Biol. Chem., August 13, 1999; 274(33): 23368 - 23377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Barbera, A. Schluter, N. Pedraza, R. Iglesias, F. Villarroya, and M. Giralt Peroxisome Proliferator-activated Receptor alpha Activates Transcription of the Brown Fat Uncoupling Protein-1 Gene. A LINK BETWEEN REGULATION OF THE THERMOGENIC AND LIPID OXIDATION PATHWAYS IN THE BROWN FAT CELL J. Biol. Chem., January 5, 2001; 276(2): 1486 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lindquist, J. M. Fredriksson, S. Rehnmark, B. Cannon, and J. Nedergaard beta 3- and alpha 1-Adrenergic Erk1/2 Activation Is Src- but Not Gi-mediated in Brown Adipocytes J. Biol. Chem., July 21, 2000; 275(30): 22670 - 22677. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
