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J Biol Chem, Vol. 273, Issue 47, 30843-30846, November 20, 1998
From The Johns Hopkins University, Baltimore, Maryland 21205
The expressions and activities of several
CCAAT/enhancer-binding proteins (C/EBP) isoforms fluctuate in the
regenerating liver. The physiological implications of these variations
in C/EBP function remain poorly characterized in the setting of
regeneration. However, lessons learned in various hepatocyte cell lines
and by studying primary hepatocytes from transgenic C/EBP
-deficient
mice suggest that the C/EBP isoforms are likely to influence
proliferation, differentiated gene expression, and survival in mature,
adult hepatocytes. In addition, these factors are potentially important modulators of liver nonparenchymal cell genes, including those that
encode matrix molecules and growth factors that are required for
successful liver regeneration. The possibility that members of the
C/EBP family of transcription factors actively participate in many
aspects of the regenerative response to liver injury is strengthened by
growing evidence that many hepatocyte mitogens and co-mitogens regulate
C/EBP activity. Furthermore, the C/EBPs themselves appear to regulate
the expression of some of these growth regulators.
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