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J Biol Chem, Vol. 273, Issue 5, 2954-2960, January 30, 1998
,,, and
From the Galectins are a family of carbohydrate-binding
proteins that share a conserved sequence and affinity for
Center for Neurobiology and Psychiatry, Department of Pharmaceutical
Chemistry, University of California, San Francisco, California
94143-0984 and the ¶ Institut Cochin de Genetique Moleculaire,
Unite INSERM 257, 24 rue de Faubourg Saint-Jaques,
75014 Paris, France
-galactosides. Some, such as galectin-1, are isolated as dimers and
have a single carbohydrate recognition domain (CRD) in each monomer,
whereas others, such as galectin-4, are isolated as monomers and have
two CRDs in a single polypeptide chain. In the course of studying mouse
colon mRNA for galectin-4, we detected a related mRNA that
encodes a new galectin that also has two CRDs in a single peptide
chain. The new galectin, galectin-6, lacks a 24-amino acid stretch in the link region between the two CRDs that is present in galectin-4. Otherwise, these two galectins have 83% amino acid identity.
Expression of both galectin-4 and galectin-6 is confined to the
epithelial cells of the embryonic and adult gastrointestinal tract.
Galectin-4 is expressed at about equal levels in colon and small
intestine but much less in stomach, whereas galectin-6 is expressed at
about equal levels throughout the gastrointestinal tract.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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