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J Biol Chem, Vol. 273, Issue 5, 2961-2970, January 30, 1998

Sequence, Structure, and Chromosomal Mapping of the Mouse Lgals6 Gene, Encoding Galectin-6

Michael A. Gitt, Yu-Rong Xia^¶, Robert E. Atchison, Aldons J. Lusis^¶, Samuel H. Barondes, and Hakon Leffler

From the  Center for Neurobiology and Psychiatry, Department of Psychiatry, and  Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143-0984 and the ^¶ Department of Medicine and Department of Microbiology and Molecular Genetics, UCLA School of Medicine, Los Angeles, California 90024

In the accompanying paper (Gitt, M. A., Colnot, C., Poirier, F., and Barondes, S. H., and Leffler, H. (1998) J. Biol. Chem. 273, 2954-2960), we reported that mouse gastrointestinal tract specifically expresses two closely related galectins, galectins-4 and -6, each with two carbohydrate recognition domains in the same peptide. Here, we report the isolation, characterization, and chromosomal mapping of the complete mouse Lgals6 gene, which encodes galectin-6, and of a fragment of a distinct gene, Lgals4, which encodes galectin-4. The coding sequence of galectin-6 is specified by eight exons. The upstream region contains two putative promoters. Both Lgals6 and the closely related Lgals4 are clustered together about 3.2 centimorgans proximal to the apoE gene on mouse chromosome 7. The syntenic human region is 19q13.1-13.3.

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