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J Biol Chem, Vol. 273, Issue 6, 3129-3131, February 6, 1998
From the Department of Physiology and Pharmacology, Auburn
University College of Veterinary Medicine, Auburn, Alabama 36849
Differential display was used to identify a new
Ras superfamily gene (Dexras1) induced by dexamethasone
(Dex) in AtT-20 cells. Treatment of AtT-20 cells with Dex for 30 min
resulted in increased mRNA for Dexras1; the highest
concentrations appeared after 2 h of treatment. The gene was also
identified in mouse heart, brain, liver, and kidney and furthermore was
induced in these tissues after Dex treatment. The deduced protein shows
regions of homology characteristic of members of the Ras superfamily of
small GTPases. Highest homology (36% identity, 57% positives) was
found with human Rap-2b, followed closely by a number of other Ras
subfamily members, suggesting that Dexras1 is probably a member of the
Ras subfamily of GTPases (members include Ras and Rap). Dexras1
is the first Ras superfamily member identified that is induced in response to steroids. The function of this gene is unknown; however, its wide distribution and rapid induction by Dex suggests the possibility of a role in glucocorticoid action in a variety of tissues.
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